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Scivation VasoXplode—Pre-workout Performance, Nitric Oxide, and Energy
Booster
We have formulated Scivation VasoXplode around ingredients that are
scientifically proven to increase performance and muscle growth. VasoXplode contains
synergistic ingredients that work together to take the results you will see to the next level
and beyond.
1. Creatine + Citrulline Malate
 Synergistically increases performance
2. Creatine + Beta-Alanine
 Synergistically increases performance and lean mass gains
3. Citrulline Malate + Arginine
 Increases blood flow and amino acid deliver to skeletal muscle, leading to
increased protein synthesis (muscle growth)
4. Tyrosine + ALCAR + Caffeine + D,L-Phenylalanine
 Increases energy and mental focus while delaying fatigue, allowing you to
workout harder and longer.
Let’s take a more indepth look at VasoXplode’s ingredients.
CreaPrime™ Blend
(Creatine Monohydrate, Di Creatine Malate)
Creatine is used in the high-energy phosphate or ATP-PCr system to regenerate
ATP. ATP, the body's main source of energy, is a molecule of adenosine (adenine + the
sugar ribose) linked to three phosphate molecules by high-energy bonds. Breaking of the
two outer bonds results in the release of energy.
When the most outer bond is broken, the energy is released and ADP and Pi are
left behind. Creatine, which is bonded to a phosphate ion, transfers energy to the ADP
and Pi molecule by breaking its own bond. This regenerates the ATP molecule, which
means one now has more energy to use. Skeletal muscle has a limited storage of creatine.
Therefore supplementing with creatine increases your ability to form ATP and therefore
increases the available energy for exercise (Casey et al. 1996 & 2000). Creatine has been
shown to:
 Increase muscle size and strength (Willoughby, 2001)
 Increase power output (Becque, 2000)
 Increase high-intensity exercise performance (Tarnopolsky, 2000)
 Increase work capacity (Rico-Sanz, 2000)
Creatine is one of the most scientifically proven-effective supplements on the market,
with creatine monohydrate being the form used in most studies.
N2ODrive Blend
(DiArg Orotate, ArgAKG, DiArg Malate, Citrulline Malate, Citric Acid)
The rate-limiting step of amino acid uptake into skeletal muscle is the
transportation of the amino acids through the blood to the skeletal muscle, which is
governed by blood flow (Wolfe, 2004). NO vasodilates blood vessels, thereby increasing
blood flow. This increase when combined with exercises means greater blood flow and
greater amino acid deliver and uptake in the working skeletal muscle. Exercise itself
results in an increase in NO production, and the increased blood flow created by exercise
is believed to be linked to the increase in protein synthesis post workout (Douglas et al.,
2004). Di-Arginine Orotate, AAKG, Di-Arginine Malate, and Citrulline Malate all
increase NO production and blood flow to skeletal muscle.
Citrulline-Malate has been shown to increase the rate of oxidative ATP
production during exercise and the rate of phosphocreatine replenishment post exercise
(Bendahan, 2002). Increasing the rate of ATP production during exercise would increase
performance and energy.
Citrulline-Malate also has anti-fatigue properties due to its ability to decrease
ammonia levels and prevent against metabolic acidosis (Callis, 1991). Decreasing the
sensation of fatigue would allow one to workout harder and longer, and thereby burn
more calories and lose more fat.
Both Citric Acid and Malic Acid (Malate) are intermediates in the Kreb’s cycle,
which produces ATP. Adding citric acid and malic acid to Primal N2O aids in ATP
production.
H-Primer Blend
(Beta-Alanine, NAC)
Beta-Alanine
It has been shown that skeletal muscle carnosine levels are correlated with
performance during high-intensity exercise (Suzuki, 2002). Carnosine is an important
metabolic buffer in skeletal muscle (Suzuki, 2002), which means it helps maintain the
acid-base balance in the presence of high H+ concentrations. High levels of H+ during
exercise cause fatigue and decrease performance.
Beta-alanine is one of the two amino acids (histidine being the other) that makes
up the dipeptide carnosine (L-beta-alanyl-L-histidine). Growing research shows Betaalanine to be a very effective performance enhancers and lean mass building supplement.
Research shows:
 Beta-Alanine availability is the limiting factor in muscle carnosine
synthesis (Hill, 2007).
 Muscle carnosine levels were higher after 10 weeks of beta-alanine
supplementation than after 4 weeks, showing that beta-alanine’s effects
are best experienced over long term supplementation (Hill, 2007).
 Beta-alanine supplementation increases total work done during aerobic
exercise (Hill, 2007).
 Beta-alanine enhances endurance performance (Zoeller, 2006)
 Beta-Alanine delays the onset of neuromuscular fatigue (Stout, 2006)
 Adding beta-alanine to creatine supplementation leads to greater increases
in lean mass than creatine alone (Hoffman, 2006).
It is clear that current research shows Beta-Alanine to be an effective performance
enhancer and enhances lean mass gains when combined with creatine.
NAC
N-acetyl-cysteine (NAC) is derived from the non-essential amino acid cysteine.
Because cysteine is very unstable, supplementing with NAC allows one to get the
benefits of cysteine. NAC is an antioxidant itself (Aruoma, 1989) and is also used to
synthesize the antioxidant glutathoine. Glutathione is a powerful antioxidant and also
regenerates vitamin C and E (Bounous, 1999)
Since intense exercise depletes glutathione (Sen, 1999), supplementation of NAC
can is beneficial to increase glutathione levels. Oxidative stress caused by free radicals
(H+), causes fatigue and muscular soreness. Supplementing with NAC will enhance
athletic performance by scavenging these free radicals (Lands, 1999) and is also a
vasodilator.
BrainDrive Blend
(N-Acetyl Tyrosine, ALCAR, Caffeine)
N-Acetyl-L-Tyrosine
Tyrosine is a nonessential amino acids used to make the catecholamine
neurotransmitters dopamine, norepinephrine, and epinephrine, thyroid hormones, and the
skin pigment melanin. Stress, such as exercise, depletes the amount of dopamine and
norepinephrine in the brain. Tyrosine supplementation has been shown
 Decrease the negative effects of stress (Banderet, 1989)
 Decrease fatigue and increase cognitive performance (Neri, 1995)
 Decrease cardiovascular stress and enhance cognitive activity (Dollins, 1995)
ALCAR
The amino acid L-Carnitine plays a vital role in energy metabolism, specifically
the transport of fatty acids into mitochondria where they can be oxidized. ALCAR is the
acetylated form of carnitine and is the most popular form of supplemental carnitine.
ALCAR is a potent antioxidant shown to have anti-aging, cardio-protective, cognitive
enhancing, and adaptogen properties. ALCAR increases exercise performance by
 Increasing fat oxidation (Hongu, 2003)
 Decreasing muscle soreness (Giamberardino, 1996)
 Decreasing lactic acid accumulation (Siliprandi, 1990).
Caffeine
Caffeine, a plant alkaloid belonging to the drug class methylxanthines and is
found in natural sources such as coffee beans, tea leaves, cocoa beans, and other plants, is
the world’s most widely used stimulant. Caffeine is a Central Nervous System (CNS)
stimulant shown to delay fatigue and improve cognitive performance.
Caffeine acts as an adenosine receptor antagonist. Adenosine decreases the
release of stimulatory/excitatory neurotransmitters (i.e. norepinephrine [NE]). Therefore,
blocking the adenosine receptor allows a greater excitation to occur by increasing NE’s
ability to activate the adrenergic receptors.
Caffeine inhibits phosphodiesterase (PDE), causing a build-up of cAMP levels
and greater effect of NE on fatty acid lipolysis. PDE blunts lipolysis; therefore inhibiting
PDE allows lipolysis to proceed at an accelerated rate. The end result is there are more
fatty acids available for oxidation after consumption of caffeine, which is one of the ways
caffeine is believes to increase performance.
D,L-Phenylalanine
D,L-Phenylalanine is a 50/50 mix of D-Phenylalanine and L-Phenylalanine. LPhenylalanine is an essential amino acid while D-Phenylalanine is a non-protein amino
acid that is not used in protein synthesis. Phenylalanine can be metabolized to PEA and is
also a precursor for norepinephrine and dopamine.
B-Vitamins
(50mg B6, 50mg B5, 100 mcg B12, 75mg Niacin)
The B vitamins are essential to whole body energy metabolism, We included the
B vitamins in VasoXplode to ensure your body has what it needs to perform at its full
potential.
Wrap-Up
VasoXplode is formulated to allow you to increase the intensity of your workouts
while delaying fatigue, which results in greater progress being made. VasoXplode
increases energy production and power output, decreases H+ accumulation and fatigue,
and increases blood flow and the deliver of amino acids to skeletal muscle, making it an
all-in-one pre-workout powerhouse. We highly recommend combining 1 serving of
VasoXplode with 1 serving of Xtend 15-20 minutes pre-workout and using Substance
WPI + Xtend during your workout to give your body EVERYTHING it needs to perform
and progress like never before.
References:
CreaPrima
Becque MD. Lochmann JD. Melrose DR. Effects of oral creatine supplementation on
muscular strength and body composition. Medicine & Science in Sports & Exercise.
32(3):654-8, 2000 Mar.
Casey, A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL. (1996) Creatine
ingestion favorably affects performance and muscle metabolism during maximal exercise
in humans. Am J Physiol. Jul;271:E31-7.
Casey A, Greenhaff PL. (2000).Does dietary creatine supplementation play a role in
skeletal muscle metabolism and performance?Am J Clin Nutr. Aug;72(2 Suppl):607S17S. Review.
Rico-Sanz J. Mendez Marco MT. Creatine enhances oxygen uptake and performance
during alternating intensity exercise. Medicine & Science in Sports & Exercise.
32(2):379-85, 2000 Feb.
Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplmentation enhances highintensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000
Dec ;10(4) :452-63.
Willoughby DS. Rosene J. Effects of oral creatine and resistance training on myosin
heavy chain expression. Medicine & Science in Sports & Exercise. 33(10):1674-81, 2001
Oct.
N2O Drive
Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ.
Citrulline/malate promotes aerobic energy production in human exercising muscle.
Br J Sports Med. 2002 Aug;36(4):282-9.
Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity of citrulline
malate on acid-base balance and blood ammonia and amino acid levels. Study in the
animal and in man. Arzneimittelforschung. 1991 Jun;41(6):660-3.
Douglas, Borsheim, and Wolfe. "Potential Ergogenic Effects of Arginine and Creatine
Supplementation" J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S.
Wolfe, et. al., In vivo muscle amino acid transport involves two distinct processes. Am J
Physiol Endocrinol Metab. 2004 Jul;287(1):E136-41.
Tyrosine
Banderet, LE, and Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor,
reduces environmental stress in humans. Brain Res Bull 22: 759-762, 1989..
Dollins AB, Krock LP, Storm WF, Wurtman RJ, Lieberman HR. L-tyrosine ameliorates
some effects of lower body negative pressure stress. Physiol Behav. 1995 Feb;57(2):22330.
Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects
of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ
Med. 1995 Apr;66(4):313-9.
ALCAR
Giamberardino MA, Dragani L, Valente R, Di Lisa F, Saggini R, Vecchiet L. Effects of
prolonged L-carnitine administration on delayed muscle pain and CK release after
eccentric effort. Int J Sports Med 1996 Jul;17(5):320-4
Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine
profiles, biochemical markers of fat metabolism and serum leptin concentration in
healthy women. J Nutr 2003 Jan;133(1):84-9
Siliprandi N, Di Lisa F, Pieralisi G, Ripari P, Maccari F, Menabo R, Giamberardino MA,
Vecchiet L. Metabolic changes induced by maximal exercise in human subjects following
L-carnitine administration. Biochim Biophys Acta 1990 Apr 23;1034(1):17-21
Beta-Alanine
Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA.
Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations
and high intensity cycling capacity. Amino Acids. 2007 Feb;32(2):225-33.
Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J.
Effect of creatine and beta-alanine supplementation on performance and endocrine
responses in strength/power athletes. Int J Sport Nutr Exerc Metab. 2006 Aug;16(4):43046.
Stout JR, Cramer JT, Mielke M, O'Kroy J, Torok DJ, Zoeller RF. Effects of twenty-eight
days of beta-alanine and creatine monohydrate supplementation on the physical working
capacity at neuromuscular fatigue threshold. J Strength Cond Res. 2006 Nov;20(4):92831.
Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K. High level of skeletal muscle
carnosine contributes to the latter half of exercise performance during 30-s maximal cycle
ergometer sprinting. Jpn J Physiol. 2002 Apr;52(2):199-205.
Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Effects of 28 days of beta-alanine
and creatine monohydrate supplementation on aerobic power, ventilatory and lactate
thresholds, and time to exhaustion. Amino Acids. 2006 Sep 5
NAC
Aruoma O,et al. (1989) The antioxidant action of N-acetylcysteine: its reaction with
hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid. Free Radical
Biol.Med.6:593-597.
Bounous G, Molson J. (1999) Competition for glutathione precursors between the
immune system and the skeletal muscle: pathogenesis of chronic fatuge syndrome. Med
Hypothesis 53;(4): 347-349.
Lands LC, Grey VL and Smountas AA. (1999) Effect of a cysteine donor on muscular
performance.J Appl Physiol. 87 (4):1381-1385.
Sen CK. (1999) Glutathione homeostasis in response to exercise training and nutritional
supplements. Molecular & Cellular Biochemistry. 196:31-42.