Download Haron Kirikiru Wk 10 discussion - PPI 1. What laboratory studies are

Haron Kirikiru
Wk 10 discussion - PPI
1. What laboratory studies are indicated for the patients receiving omeprazole? Explain the
significance of these studies. How long is treatment with this proton pump inhibitor (PPI)
indicated?
2.What is the rationale for the use of PPIs to treat GERD?
3. Why are antacids no longer the mainstay of treatment for acid-related gastric ulcers and/or
reflux disease.
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1.) Assessment of renal and liver function and complete blood count may be recommended prior to
initiating omeprazole therapy.
The drug is indicated to be taken PO 20 mg/day for 4-8 weeks
2.) PPIs are preferred in the treatment of GERD to H2 receptor antagonist due to their aggressive
course of action in treating GERD. If untreated, GERD can lead to more serious disorders such as
erosive esophagitis and Barret esophagus, a precancerous condition. PPI inhibit the action of
the proton pump, significantly reducing the level of HCL produced, while H2 receptor antagonist
only inhibit parietal cell stimulation attributed to H2 receptors activation, with reduced effect on
ACh and gastrin receptors.
3.) Antacid are no longer the mainstay of acid related gastric ulcers and/or GERD treatment due to
their limited effect on acid production, they instead act by neutralizing gastric acid. This offers
only temporary relief if the root cause of acidity is in the proton pump. Antacid use may also
lead to an alkaline environment in the stomach, a condition that may inhibit absorption of other
drugs and substances that are sensitive to pH changes.
Source:
1. Pharmacology and the nursing process
2. Pathophysiology for health practitioners