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Preventive Effect of Modified Citrus Pectin against Aluminium Induced Neurotoxicity Aluminium (Al) is a powerful neurotoxin and has been associated with various cognitive disorders. Al causes extensive damage to the nervous system by accelerating oxidative damage to biomolecules like lipid, protein and nucleic acids. Natural antioxidants, which alleviate the oxidative stress or induce the cellular antioxidant milieu would most probably treat and/or protect against Al poisoning. Modified citrus pectin (MCP) is a complex polysaccharide obtained from the inner peel pulp of citrus fruit. MCP is known with antioxidant, immune modulator and cancer preventive properties. It has the ability to bind toxic heavy metals and excrete them while not disturbing the essential minerals in healthy humans. The present study investigated the neuroprotective effect of MCP against Al induced oxidative stress and DNA damage in the brain cerebral cortex of Swiss albino mice. The study was conducted on a control and three experimental groups with a total number of 24 mice. All applications were carried out orally in a period of 30 days. Group I (control) was administered physiological salin (% 0.9); group II was administered AlCl2 (34 mg/kg/day); group III was administered MCP (50 mg/kg/day); group IV was administered AlCl2 (34 mg/kg/day) and MCP (50 mg/kg/day) with 2 hour intervals respectively. Superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and acetylcholine esterase activities, total glutathione level and lipid peroxidation were measured. Histopathological changes were investigated. DNA damage was determined by single cell gel electrophoresis (SCGE). The findings manifested that MCP could alleviate the changes in endogenous antioxidants, prevent lipid peroxidation, tissue damage and functional defects in neuronal signaling resulted from Al toxicity. Besides, DNA damage can be decreased effectively with the application of MCP.