Download Metabolic, Humoral, and Inflammatory Factors

Metabolic, Humoral, and
Inflammatory Factors
Gaps
• Better define underlying etiologies and
pathophysiology
• More specific nomenclature
– Multimodal brain syndrome,
– TMF: subsyndromes
• Vascular Neuroexecutive Syndrome
• Animal models, esp for mood and physical
function
• Mechanisms by which exercise and
physical activity affect mood, cognition and
physical function
Research Priorities
• Expand existing basic, epi, and intervention
studies to examine all three domains
• Animal models of TMF and methods for studying
mood and physical function in animal models
• Mechanisms of exercise and physical activity
effects
Research Opportunities
• Effects of function promoting anabolic
therapies on cognition and mood in clinical
trials
• Effects of immune modulation on
cognition, mood and physical function
• Human intervention trials
– Multimodality interventions
– High risk groups
– Include all three domains as outcomes