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UNIVERSITY COLLEGE LONDON THE UCL CANCER INSTITUTE JOB DESCRIPTION POST: Research Associate - Bioinformatician, Full-time GRADE: Grade 7 (£32,375 - £39,132 per annum including London Allowance) RESPONSIBLE TO: Dr. Suzana Hadjur ACCOUNTABLE TO: Dr. Suzana Hadjur The Genome Organization and Function Group headed by Dr. Suzana Hadjur is seeking a Bioinformatician to start immediately. Using experimental and computational approaches, the group has a broad interest in genome organization and its influence on gene regulation. We use molecular methods (Hi-C, 4C-Seq, ChIP and 3D microscopy) and computational analysis to investigate the organisation of mammalian chromosomes. Recent work has shown that a set of chromatin proteins, called cohesins are functionally important for the looping of regulatory elements at individual genes (Hadjur S et al., Nature 2009; Parelho V & Hadjur S et al., Cell 2008) as well as global chromosome structure (Sofueva S et al. EMBO J 2013). The full-time bioinformatics position is immediately available and funded by the Medical Research Council in collaboration with Illumina, Inc for two years in the first instance. The appointee will be supervised by Dr. Hadjur and will be integrated into both the bioinformatics environment at UCL and into the European FP7 EpiGeneSys community, to which the group has membership. The ideal candidate should have a genomics or computer science based PhD, be highly ambitious and self-motivated and possess significant experience in applied bioinformatics, specifically having worked with next-generation sequencing datasets. The candidate will also be expected to have a working knowledge of R and statistics. The post holder will be expected to analyse, integrate and interpret multiple datasets simultaneously (including ChIP-Seq, RNASeq and data arising from genome wide 3C-based studies, HiC and 4C-Seq). The work will also involve management of the data, application of cutting-edge algorithms, and development of appropriate post-analysis strategies and pipelines. The hypotheses generated through the analysis will be validated within the laboratory and therefore close interaction is expected with lab members. This post represents an excellent opportunity for an intelligent, self-motivated and creative bioinformatician to work in the exciting field of genome organization and to take advantage of the large amounts of NGS data currently available within the group and interpret it in novel ways. The candidate should: Have prior experience with the analysis and interpretation of genomics data (ideally with nextgeneration sequencing data) Possess strong programming and statistics skills Be proficient with R and have a solid statistical background Be familiar with working in a linux environment Posses the ability to develop integrated databases of biological data Have experience in common bioinformatics packages such as Bioconductor and Bioperl Principal Duties & Responsibilities 1. To work as part of a multidisciplinary team of scientists, developing good working relationships within the team, and to establish and maintain excellent communication links. 2. To develop a bioinformatics strategy to integrate different genomics signals deriving from ChIP-Seq, RNA-Seq and 3C-Based-seq profiles obtained from the same samples. 3. To maintain appropriate databases, keeping accurate written and computerised records and to ensure that these records are stored in a secure place. To maintain confidentially of all electronically stored personal data in line with the provisions of the Data Protection Act. 4. To develop a systems-type analysis pipeline. To integrate generated data with existing genome annotation using e.g. UCSC and ENSEMBL 5. Provide basic training in bioinformatics to lab members to increase awareness and knowledge of the methodologies used for analysis. 6. Provide supervision of bioinformatics aspects of projects in our laboratory in related areas. Keep up to date on current publications relevant for our projects and integrate published datasets accordingly. 7. To contribute to the writing of publications and grant applications for this and related studies. 8. Keep up to date with scientific developments in this and related fields and communicate these developments within the group. 9. To attend research seminars and other departmental meetings as required. 10. To participate in any group/laboratory duties commensurate with the grade as required. 11. To be aware of and act upon: Disciplinary procedure and Disciplinary rules Grievance procedure Section 7 and 8 of the Health and Safety at Work Act Departmental Fire Guidelines Equal Opportunities Policy 12. To comply with the Health & Safety regulations of the department. The hours of work and the distribution of these are at the discretion of the Head of Department. University College London has adopted an equal opportunities policy and specific regard should be taken of its content in relation to the treatment of employees or potential employees. Please note that UCL operates a system of cashless pay directly into a bank or building society account. All new employees are, therefore, required to have an account with a bank or building society as soon as they commence their appointment. Failure to produce bank details on the first day will result in a delay in payment. This job description is not meant to be restrictive or exhaustive and duties may change in response to changing circumstances. These will be discussed with the postholder. Person Specification The following is a list of essential and desirable requirements needed in order to do the job. Applicants will be shortlisted solely on the extent to which they meet these requirements. Competency Knowledge and Experience Evidence Communication PhD in relevant area (eg, genomics, computational biology) Basic statistics Bioinformatics expertise (eg analysis of DNA sequence data, ChIP data, gene expression data, fragment analysis) Laboratory research experience/understanding in biosciences field (genomics and cell biology). Excellent oral and written communication skills. Keen to learn and share scientific ideas. Excellent inter-personal skills. E/D E E E D E E E Teamwork and Motivation Willingness to work as part of a team and to effectively exchange information with team members. Willingness to work flexibly in order to achieve project demands E E Service Delivery Ability to react effectively to requests from the Team Leader and other colleagues. E Planning and Organising Resources Ability to organise and prioritise work. Ability to work safely and effectively with a minimum of supervision. E E Initiative and Problem Solving Ability to use initiative. Ability to resolve operational difficulties. Desire to develop the role. E E D E = Essential D = Desirable Date : 13 January 2014