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The University of Sheffield Faculty of Medicine, Dentistry & Health Department of Infection & Immunity Mediators of Histidine Phosphorylation in Innate Immunity. Supervisor: Dr Richmond Muimo Project:Reversible phosphorylation of the histidine amino acid residue is increasingly recognised as a key phosphorylation event. Proteins containing phosphohistidine (pHis) are implicated in various mammalian cellular processes including regulation of ion channels, apoptosis, cell proliferation and differentiation, inflammation, chromatin biology, cancer and cell signalling. However, much remains to be understood about the role and extent of the modification in mammalian cell biology. The study of both the extent and functional role of pHis in signaling, either in vitro or in vivo, is complicated by the instability of the pHis modification. As a consequence, we are currently handicapped by a chronic lack of chemical and biochemical tools with which to study histidine phosphorylation. The aim of this project is to develop tools for the study of the role of histidine phosphorylation in mammalian cells. We will incorporate novel stable analogues of phosphohistidine that we have recently synthesized into relevant peptide sequence to develop potent and specific reagents as protein-protein interaction and PHP inhibitors. Entry Requirements: Candidates must have a first or upper second class honors degree or significant research experience. Enquiries: Interested candidates should in the first instance contact Ricmond Muimo, [email protected] How to apply: Please complete a University Postgraduate Research Application form and attach at least two references to your application. To complete the application form please visit: www.shef.ac.uk/postgraduate/research/apply. Please clearly state the prospective main supervisor in the respective box and select ‘Infection & Immunity’ as the department. Closing date: Open