* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download PhD Position – Identification of novel causative genes for
Survey
Document related concepts
Quantitative trait locus wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Genome (book) wikipedia , lookup
Heritability of IQ wikipedia , lookup
Population genetics wikipedia , lookup
Epigenetics of neurodegenerative diseases wikipedia , lookup
Microevolution wikipedia , lookup
Designer baby wikipedia , lookup
Irving Gottesman wikipedia , lookup
Public health genomics wikipedia , lookup
Biology and consumer behaviour wikipedia , lookup
Transcript
PhDPosition–Identificationofnovelcausativegenesforinherited neurodegenerativedisorders Description We are a highly motivated, international team of researchers belonging to the Molecular Neurogenomics Group at the VIB Department of Molecular Genetics (http://www.vib.be/en/research/scientists/Pages/Albena‐Jordanova‐Lab.aspx), looking foranenthusiasticcolleaguewhowantstoperformhis/herPhDstudyonidentificationof novelcausativegenesforhumanneurodegenerativedisorders. MaintopicofourlabisgenediscoveryinlargecollectionsofpatientswithCharcot‐Marie‐ Tooth disease, the most common neurodegenerative disorder of the peripheral nervous system.Webelievethatbyfindingnovelcausativegenes,weprovidemechanisticinsights intotheethologyofthesedevastatingdisordersandoffertreatmentopportunities. In the advertised research project, the PhD student will use genetic approaches for mappingofhumandisorders,combinedwiththemostrecentadvancesinnext‐generation sequencingandbioinformaticstechnologies.Thecausalityofidentifiedmutationsandthe molecular pathomechanisms they are triggering will be further tested in appropriate cellular and animal models. Genotype‐phenotype correlations will be established to facilitatethefuturediagnosisandprognosisofthepatients. As part of the Department of Molecular Genetics (http://www.molgen.vib‐ua.be) and VIB (www.vib.be),thesuccessfulapplicantwillbenefitfromaccesstocentralizedfacilitieswith expertiseingenomics,functionalgenomicsandcellbiology,structuralbiology,proteomics, cutting‐edge microscopy, technology development, and bioinformatics. VIB provides a highlyinteractiveenvironmentandampletrainingopportunitiesforPhDandpostdoctoral researchers.Inaddition,theVIBDepartmentofMolecularGeneticsislocatedinthecityof Antwerp, the capital of Flanders, offering a culturally and historically rich, and ethnically diverseenvironment. Profile Predoctoralcandidatesareexpectedtohave: Masterdegreeinmedicineorbiomedicine; Stronginterestinhumangenetics; Knowledgeinneurologyorbioinformaticsorbiostatisticswouldbeanadvantage Abilitytosummarizedataextractedfromtheliterature,defineresearchobjectives, showself‐motivation,flexibilityandteamspirit; ExcellentverbalandwrittenEnglishcommunicationskills Howtoapply? Pleasee‐mailyour: ‐ DetailedCV ‐ Onepagemotivationletter,descriptionofpreviousresearchexperience(ifany)and researchinterests ‐ Namesandaddressesof2referees to:[email protected]‐ua.be Contact:MoredetailsontheprojectcanbeobtainedfromProf.AlbenaJordanova,PhD ([email protected]‐ua.be) VIBDepartmentofMolecularGenetics, UniversityofAntwerp‐CDE Universiteitsplein1 2610ANTWERPEN Tel:+32‐3‐265.10.25