Download PhD Position – Identification of novel causative genes for

PhDPosition–Identificationofnovelcausativegenesforinherited
neurodegenerativedisorders
Description
We are a highly motivated, international team of researchers belonging to the Molecular
Neurogenomics Group at the VIB Department of Molecular Genetics
(http://www.vib.be/en/research/scientists/Pages/Albena‐Jordanova‐Lab.aspx), looking
foranenthusiasticcolleaguewhowantstoperformhis/herPhDstudyonidentificationof
novelcausativegenesforhumanneurodegenerativedisorders.
MaintopicofourlabisgenediscoveryinlargecollectionsofpatientswithCharcot‐Marie‐
Tooth disease, the most common neurodegenerative disorder of the peripheral nervous
system.Webelievethatbyfindingnovelcausativegenes,weprovidemechanisticinsights
intotheethologyofthesedevastatingdisordersandoffertreatmentopportunities.
In the advertised research project, the PhD student will use genetic approaches for
mappingofhumandisorders,combinedwiththemostrecentadvancesinnext‐generation
sequencingandbioinformaticstechnologies.Thecausalityofidentifiedmutationsandthe
molecular pathomechanisms they are triggering will be further tested in appropriate
cellular and animal models. Genotype‐phenotype correlations will be established to
facilitatethefuturediagnosisandprognosisofthepatients.
As part of the Department of Molecular Genetics (http://www.molgen.vib‐ua.be) and VIB
(www.vib.be),thesuccessfulapplicantwillbenefitfromaccesstocentralizedfacilitieswith
expertiseingenomics,functionalgenomicsandcellbiology,structuralbiology,proteomics,
cutting‐edge microscopy, technology development, and bioinformatics. VIB provides a
highlyinteractiveenvironmentandampletrainingopportunitiesforPhDandpostdoctoral
researchers.Inaddition,theVIBDepartmentofMolecularGeneticsislocatedinthecityof
Antwerp, the capital of Flanders, offering a culturally and historically rich, and ethnically
diverseenvironment.
Profile
Predoctoralcandidatesareexpectedtohave:
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Masterdegreeinmedicineorbiomedicine;
Stronginterestinhumangenetics;
Knowledgeinneurologyorbioinformaticsorbiostatisticswouldbeanadvantage
Abilitytosummarizedataextractedfromtheliterature,defineresearchobjectives,
showself‐motivation,flexibilityandteamspirit;
ExcellentverbalandwrittenEnglishcommunicationskills
Howtoapply?
Pleasee‐mailyour:
‐ DetailedCV
‐ Onepagemotivationletter,descriptionofpreviousresearchexperience(ifany)and
researchinterests
‐ Namesandaddressesof2referees
to:[email protected]‐ua.be
Contact:MoredetailsontheprojectcanbeobtainedfromProf.AlbenaJordanova,PhD
([email protected]‐ua.be)
VIBDepartmentofMolecularGenetics,
UniversityofAntwerp‐CDE
Universiteitsplein1
2610ANTWERPEN
Tel:+32‐3‐265.10.25