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Transcript
The Faculty Case of Kunming MedicalUniversity Teaching Department: Department of Basic Medicine: Pharmacology Teacher Name: Luo Haiyun Course Name pharmacology Teacher Luo haiyun 职 称 Associate Professor Grad 2011 e 课 型(大、小) Professional 大课 MBBS 学时 2hour Pharmacologic Management of Parkinsonism 授课题目(章、节) 教材(名称、主编、出版社、 "Pharmacology" Zhou Hao editor 出版时间、版本) Objectives and Requirements: 1, To master Levodopa Mechanism of Action Pharmacological effects and therapeutic application Pharmacokinetics Adverse effects Drug interactions and Contraindications Teaching major and difficult: The concept of drugs The difference between drugs and poisons Pharmacodynamics Pharmacokinetics Teaching methods: Multimedia courseware, application problems Guiding Method Multimedia and writing on the blackboard design elements: the use of drugs in various dosage forms show powerpoint software to guide students into this new discipline, for some preliminary understanding a few basic concepts to master. 1 The feature of Parkinsonism Classification of drugs Levodopa 10min 3min Dopamine does not cross the blood-brain barrier and if given into the peripheral circulation has no therapeutic effect in parkinsonism. However, (–)-3-(3,4-dihydroxyphenyl)-L-alanine (levodopa), the immediate metabolic precursor of dopamine, does enter the brain (via an L-amino acid transporter, LAT), where it is decarboxylated to dopamine (see Figure 6–5). Several noncatecholamine dopamine receptor agonists have also been developed and may lead 10min to clinical benefit, as discussed in the text that follows. Dopamine receptors of the D1 type are located in the pars compacta of the substantia nigra and presynaptically on striatal axons coming from cortical neurons and from dopaminergic cells in the substantia nigra. The D2 receptors are located postsynaptically on striatal neurons and presynaptically on axons in the substantia nigra belonging to neurons in the basal ganglia. The benefits of dopaminergic antiparkinsonism drugs appear to depend mostly on stimulation of the D2 receptors. However, D1-receptor stimulation may also be required for maximal benefit and one of the newer drugs is D3 -selective. Dopamine agonist or partial agonist ergot derivatives such as lergotrile and bromocriptine that are powerful stimulators of the D2 receptors have antiparkinsonism properties, whereas certain dopamine blockers that are selective D2 antagonists can induce parkinsonism. 2 Mechanism of Action Pharmacological effects therapeutic application Pharmacokinetics Adverse effects Drug interactions Contraindications 20min and and MAO inhibitors 10min Anticholinergics of CNS 10min Amantadine 10min Drug for Alzheimer’s disease conclusion 3min 4min 5min 注:主要包括具体教学内容与时间安排,教学辅助手段的运用,主要专业外语 词汇,教 3 学内容的补充等。 小 Levodopa Mechanism of Action Pharmacological effects and therapeutic application Pharmacokinetics Adverse effects Drug interactions and Contraindications 结 1. 2. 复习思 考题、 3. 作业题 4. Levodopa Mechanism of Action Pharmacological effects and therapeutic application Pharmacokinetics 5. Adverse effects 6. Drug interactions and Contraindications 下次课 预习要 点 实施情 况及分 析 教研室 审阅意 见: 教研室主任签名: 年 月 日 4