Download 教案- Pharmacologic Management of Parkinsonism

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Transcript
The Faculty Case of Kunming
MedicalUniversity
Teaching Department: Department of Basic Medicine: Pharmacology Teacher Name: Luo Haiyun
Course Name pharmacology
Teacher
Luo haiyun
职
称
Associate
Professor
Grad 2011
e
课 型(大、小)
Professional
大课
MBBS
学时
2hour
Pharmacologic Management of Parkinsonism
授课题目(章、节)
教材(名称、主编、出版社、 "Pharmacology" Zhou Hao editor
出版时间、版本)
Objectives and Requirements: 1, To master

Levodopa
Mechanism of Action
Pharmacological effects and therapeutic application
Pharmacokinetics
Adverse effects
Drug interactions and Contraindications
Teaching major and difficult:
The concept of drugs
The difference between drugs and poisons
Pharmacodynamics
Pharmacokinetics
Teaching methods:
Multimedia courseware, application problems Guiding Method
Multimedia and writing on the blackboard design elements: the use of drugs in various dosage forms show
powerpoint software to guide students into this new discipline, for some preliminary understanding a few basic
concepts to master.
1
 The feature of Parkinsonism
 Classification of drugs


 Levodopa
10min
3min
Dopamine does not cross the blood-brain
barrier and if given into the peripheral
circulation has no therapeutic effect in
parkinsonism. However,
(–)-3-(3,4-dihydroxyphenyl)-L-alanine
(levodopa), the immediate metabolic precursor
of dopamine, does enter the brain (via an
L-amino acid transporter, LAT), where it is
decarboxylated to dopamine (see Figure 6–5).
Several noncatecholamine dopamine receptor
agonists have also been developed and may lead 10min
to clinical benefit, as discussed in the text
that follows.
Dopamine receptors of the D1 type are located
in the pars compacta of the substantia nigra
and presynaptically on striatal axons coming
from cortical neurons and from dopaminergic
cells in the substantia nigra. The D2 receptors
are located postsynaptically on striatal
neurons and presynaptically on axons in the
substantia nigra belonging to neurons in the
basal ganglia. The benefits of dopaminergic
antiparkinsonism drugs appear to depend mostly
on stimulation of the D2 receptors. However,
D1-receptor stimulation may also be required
for maximal benefit and one of the newer drugs
is D3 -selective. Dopamine agonist or partial
agonist ergot derivatives such as lergotrile
and bromocriptine that are powerful
stimulators of the D2 receptors have
antiparkinsonism properties, whereas certain
dopamine blockers that are selective D2
antagonists can induce parkinsonism.
2
Mechanism of Action
Pharmacological
effects
therapeutic application
Pharmacokinetics
Adverse effects
Drug
interactions
Contraindications
20min
and
and
MAO inhibitors
10min
Anticholinergics of CNS
10min
Amantadine
10min
Drug for Alzheimer’s disease
conclusion
3min
4min
5min
注:主要包括具体教学内容与时间安排,教学辅助手段的运用,主要专业外语 词汇,教
3
学内容的补充等。
小
 Levodopa
Mechanism of Action
Pharmacological effects and therapeutic application
Pharmacokinetics
Adverse effects
Drug interactions and Contraindications
结
1.
2.
复习思
考题、 3.
作业题 4.
Levodopa
Mechanism of Action
Pharmacological effects and therapeutic application
Pharmacokinetics
5.
Adverse effects
6.
Drug interactions and Contraindications
下次课
预习要
点
实施情
况及分
析
教研室
审阅意
见:
教研室主任签名:
年
月
日
4