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THESIS: Decreased Lactobacillus populations after erythromycin treatment hinders the
induction of oral tolerance to fed ovalbumin
STUDENT: Sydney E. Lambert
DEGREE: Master of Science
COLLEGE: Science
DATE: May, 2012
Oral tolerance is an immunologic hyporesponsiveness to an orally administered
antigen. Probiotics (beneficial intestinal bacteria), T regulatory cells (Tregs), and
dendritic cells (DCs) are all essential for generating tolerance and suppressing immune
responses toward harmless antigens. Antibiotics are commonly prescribed to fight
infections and often necessary for maintaining health, but they can disrupt the normal
intestinal microbial populations. There is increasing epidemiologic evidence that
suggests that antibiotic usage correlates with the development of irritable bowel
disorders, which often result due to a breakdown in immune tolerance. This study
investigated the effect of the antibiotic erythromycin on oral tolerance induction to
ovalbumin (OVA). The results demonstrate that antibiotic treatment prior to exposure to
fed antigen prevents tolerance to that antigen, and this correlated with a reduction in
intestinal Lactobacillus populations. Furthermore, antibiotic treatment resulted in a
significant decrease in the tolerogenic CD11c+/CD11b+/CD8α- MLN DCs independent of
tolerizing treatment.