Download CCND1 antibody - middle region (AVARP03037_P050)

CCND1 antibody - middle region (AVARP03037_P050)
Data Sheet
Product Number
Product Name
Size
Gene Symbol
Alias Symbols
Nucleotide Accession#
Protein Size (# AA)
Molecular Weight
Product Format
NCBI Gene Id
Host
Clonality
Official Gene Full Name
Description
Peptide Sequence
Target Reference
Description of Target
Partner Proteins
AVARP03037_P050
CCND1 antibody - middle region (AVARP03037_P050)
50ug
CCND1
BCL1; D11S287E; PRAD1; U21B31
NM_053056
295 amino acids
34kDa
Lyophilized powder
595
Rabbit
Polyclonal
Cyclin D1
This is a rabbit polyclonal antibody against CCND1. It was validated on Western Blot using a cell lysate as a
positive control. Aviva Systems Biology strives to provide antibodies covering each member of a whole protein
family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a
target protein. For availability of antibody needed for your experiment, please inquire ().
Synthetic peptide located within the following region:
ACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Kibel,A.S., (2008) Prostate 68 (11), 1179-1186
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic
periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases.
Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact
with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations,
amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a
variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly
conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance
throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct
expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This
cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required
for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the
expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene,
which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to
tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for
this gene. Please see the Entrez Gene record to access additional publications.
AKAP8, AREG, ATF5, ATP5C1, CASP2, CDK11B, CDK14, CDK4, CDK6, CDKN1A, CDKN1B, CRABP2,
DMTF1, DTNBP1, EFEMP2, EIF3K, MAF1, MAPK4, MCM10, NCOA2, NPDC1, PCNA, RARA, RBL2,
RUNX1, VDR, AKAP8, ATP5C1, CASP2, CDK11B, CDK4, CDK6, CDKN1A, CDKN1B, CRABP2, DTNBP1,
EFEMP2, EIF3K, MAF1, MCM10, NPDC1, PCNA, RAR
Reconstitution and
Storage
Lead Time
Blocking Peptide
Add 50 ul of distilled water. Final anti-CCND1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose.
For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Immunogen
The immunogen for anti-CCND1 antibody: synthetic peptide directed towards the middle region of human
CCND1
P24385
Swissprot Id
Protein Name
Protein Accession #
Purification
Species Reactivity
Application
Predicted Homology
Based on Immunogen
Sequence
Domestic: within 24 hours delivery International: 3-5 business days
For anti-CCND1 antibody is Catalog # AAP30439 (Previous Catalog # AAPP01023)
G1/S-specific cyclin-D1
NP_444284
Affinity Purified
Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rat, Zebrafish
WB
Guinea pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; African clawed frog: 90%; Bovine: 90%; Chicken:
90%; Dog: 90%; Horse: 90%; Zebrafish: 81%
Human 721_B
WB Suggested Anti-CCND1 Antibody Titration:
Image 1
0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysate
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This product is for Research Use Only. Not for diagnostic, human, or veterinary use.
Optimal conditions of its use should be determined by end users.