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DISCOVERY mRNA Detection System α-SYN 10X lg Kappa in tonsil Discover the power and freedom of fully automated mRNA ISH We have collaborated with Advanced Cell Diagnostics (ACD) to bring you a fully automated mRNA detection system enabling detection of single RNA molecules within formalin-fixed, paraffin-embedded tissue. Visualise the abundance of mRNA targets within the cellular and morphological context • See the cellular origin of secreted proteins • Study the critical relationships between gene, messenger and protein • Explore the effects of non-coding RNA sequences • DAB and Red detection available Time is yours, take it back • Enjoy the ease and convenience of walk-away automation • Deliver standardised, reproducible results • Free scientists’ hands for other value added work DISCOVERY reagents, instruments and RNAscopesVS products are for research use only. Not for use in diagnostic procedures. DISCOVERY ULTRA Eliminate 70% of your manual processes. Now you can perform highly sensitive and specific mRNA ISH using RNAscopeVS* research with a fraction of the effort. Here is an example of laboratory process before and after mRNA ISH automation. This could be your success story. 197 Total processes 166 NVA processes Current manual method 30 Total processes 0 NVA processes Automation potential NVA = Non-Value Added Harnessing the proven combination of RNAscopeVS, the mRNA DAB or RED detection kits and VENTANA DISCOVERY instruments, research labs are able to quickly visualise and quantify mRNA within the context of tissue microscopy in the lab. The DISCOVERY ULTRA research instrument offers our highest level of protocol flexibility for the most challenging assays and for rapid assay development. The DISCOVERY ULTRA research instrument allows increased productivity in a fully automated system that empowers you and your lab to focus on the research, not the tasks. GLI1 20X DISCOVERY mRNA DAB detection kit Catalog number Ordering code Product name 950-210 06883354001 DISCOVERY 1x SSC 760-225 06634443001 mRNA Amplification, Pretreatment & DAB kit ACD catalog number Product name 320600 RNAscopeVS FFPE reagent kit 313906 RNAscopeVS positive control probe – PPIB 310048 RNAscopeVS negative control probe – DapB For a given target, the customer will also need to request a target probe 300036 RNAscopeVS target probe(s) Also requires the purchase of a staining procedure license and a user-fillable probe dispenser, sold separately lg Lambda in tonsil DISCOVERY mRNA RED detection kit Catalog number Ordering code Product name 950-210 06883354001 DISCOVERY 1x SSC 760-235 07074654001 mRNA RED, Amplification & Pretreatment PTO kit ACD catalog number Product name 320610 RNAscopeVS FFPE reagent kit 310048 RNAscopeVS positive control probe – PPIB Note: RNAscopeVS positive control probes are available for PPIB, POLR2A and UBC genes, across human, mouse and rat species. For a given target, the customer will also need to request a target probe 300036 RNAscopeVS target probe(s) Also requires the purchase of a staining procedure license and a user-fillable probe dispenser, sold separately The use of positive and negative control probes is highly recommended with both mRNA DAB and RED detection kits for validation of assay performance. ACD provides positive and negative control probes and cell line controls designed to work with RNAScope VS FFPE reagent kits. Tissue control slides are available through Ventana. The use of controls on every run is strongly recommended to demonstrate reproducibility and facilitate assay development. Roche Diagnostics (Schweiz) AG Industriestrasse 7 CH-6343 Rotkreuz Switzerland Tel: +41 (0)41 799 61 00 Fax: +41 (0)41 799 65 45 www.roche.com www.ventana.com DISCOVERY reagents, instruments and RNAscopesVS products are for research use only. Not for use in diagnostic procedures. *RNAscopeVS FFPE Target Probes must be ordered separately, please see ACD Target Probe Search www.acdbio.com/db.php. VENTANA DISCOVERY mRNA Detection System is intended for use with Advanced Cell Diagnostics RNAscopeVS reagents, which are sold separately and available from ACD. Ventana does not provide sales or technical support for ACD products. VENTANA DISCOVERY products and RNAscopeVS, when used with VENTANA DISCOVERY instruments, are for research use only. Not for use in diagnostic procedures. © 2013 Ventana Medical Systems, Inc. VENTANA, the VENTANA logo and DISCOVERY are trademarks of Roche. All other trademarks are the property of their respective owners. E4059 1213C 07244363001 VENTANA Empowering | Innovation