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Arcadia Unified School District Arcadia High School Biology Grades 9-12 Cell Biology 1. Students understand that the fundamental life process of plants and animals depend on a variety of chemical reactions that occur in specialized areas of the organism’s cells. • Describe cells enclosed within semi-permeable membranes that regulate their interaction with their surroundings (1.a) P Investigate how enzymes are proteins that catalyze biochemical reactions by lowering the activation energy (1.b) P Assess the impact of varying temperature, ionic conditions, and the pH on different enzymes (1.b) P Recognize prokaryotic cells, eukaryotic cells (including those from plants and animals), and viruses differ in complexity and general structure (1.c) P Examine the central dogma of molecular biology and trace the flow of information from transcription of ribonucleic acid (RNA) in the nucleus to translation of proteins on ribosomes in the cytoplasm (1.d) • Distinguish between the roles of the endoplasmic reticulum and Golgi apparatus in the secretion of proteins (1.e) • Explain that usable energy is captured from sunlight by chloroplasts and is stored through the synthesis of sugar from carbon dioxide (1.f) • Demonstrate the role of the mitochondria in making stored chemical-bond energy available to cells by completing the breakdown of glucose to carbon dioxide. (1.g) P Most macromolecules (polysaccharides, nucleic acids, proteins, lipids) in cells and organisms are synthesized from a small collection of simple precursors (1.h) Required Labs: Diffusion Lab Liver Lab Protein Synthesis Lab Elodea and BTB Page 1 of 10 Revised May 2008 Page 2 of 10 Revised May 2008 Genetics (Meiosis and Fertilization) 2. Students explore and understand that mutation and sexual reproduction lead to genetic variation in a population. P • • • • • P Recognize that meiosis is an early step in sexual reproduction in which the pairs of chromosomes separate and segregate randomly during cell division to produce gametes containing one chromosome of each type (2.a) Understand only certain cells in a multicellular organism undergo meiosis (2.b) Analyze how random chromosome segregation explains the probability that a particular allele will be in a gamete (2.c) Demonstrate how new combinations of alleles may be generated in a zygote through the fusion of male and female gametes (fertilization) (2.d) Demonstrate how approximately half of an individual’s DNA sequence comes from each parent (2.e) Relate the role of chromosomes in determining an individual’s sex (2.f) Demonstrate how to predict possible combinations of alleles in a zygote from the genetic makeup of the parents (2.g) Required Labs: Modeling Meiosis Lab Probability Lab Punnett Squares Genetics (Mendel’s Laws) 3. Students understand that a multicellular organism develops from a single zygote, and its phenotype depends on its genotype, which is established at fertilization. Explore how to predict the probable outcome of phenotypes in a genetic cross from the genotypes of the parents and mode of inheritance (autosomal or X-linked, dominant or recessive) (3.a) • Relate the genetic basis for Mendel’s laws of segregation and independent assortment (3.b) P Genetics (Molecular Biology) Page 3 of 10 Revised May 2008 4. Students explain that genes are a set of instructions encoded in the DNA sequence of each organism that specify the sequence of amino acids in proteins characteristic of that organism. • Sequence the general pathway by which ribosomes synthesize proteins, using tRNAs to translate genetic information in mRNA (4.a) P Apply the genetic coding rules to predict the sequence of amino acids from a sequence of codons in RNA (4.b) • Analyze the impact of mutations in the DNA sequence of a gene and how it may or many not affect the expression of the gene or the sequence of amino acids in an encoded protein (4.c) • Analyze how specific types of cells containing the same genome may produce specific proteins unique to that type of cell (4.d) • Differentiate between proteins and how they differ in the number and sequence of amino acids (4.e) Required Lab: Protein Synthesis Lab Genetics (Biotechnology) 5. Students understand that the genetic composition of cells can be altered by incorporation of exogenous DNA into the cells. Model the general structures and functions of DNA, RNA, and protein (5.a) • Apply the base-pairing rules to explain precise copying of DNA during semiconservative replication and transcription of information from DNA into mRNA (5.b) • Research how genetic engineering (biotechnology) is used to produce novel biomedical and agricultural products (5.c) P Required Lab: Make a Model Lab Ecology Page 4 of 10 Revised May 2008 6. Students understand stability in an ecosystem is a balance between competing effects. P P P P Describe biodiversity as the sum total of different kinds of organisms. Predict how alterations of habitats affect biodiversity (6.a) Relate the influence on an ecosystem of changes in climate, human activity, non-native species, and populations (6.b) Evaluate how fluctuations in population size in an ecosystem are determined by the relative rates of birth, immigration, emigration, and death (6.c) Trace how water, carbon, and nitrogen cycle between abiotic resources and organic matter in the ecosystem and how oxygen cycles through photosynthesis and respiration (6.d) Page 5 of 10 Revised May 2008 P P Analyze the roles of producers, consumers and decomposers in the ecosystem (6.e) Understand that as energy is transferred at each trophic level in the food web, most energy is lost as heat, as represented in an energy pyramid (6.f) Evolution (Population Genetics) 7. Students understand that the frequency of an allele in a gene pool of a population depends on many factors and may be stable or unstable over time. Investigate why natural selection acts on the phenotype rather than the genotype of an organism (7.a) • Evaluate why alleles that are lethal in a homozygous individual may be carried in a heterozygote and thus maintained in a gene pool (7.b) • Understand new mutations are constantly being generated in a gene pool (7.c) P Predict how variation within a species increases the likelihood that at least some members of a species will survive under changed environmental conditions (7.d) P Required Lab: Adaptation Lab Natural Selection Lab Evolution (Speciation) 8. Students understand that evolution is the result of genetic changes that occur in constantly changing environments. Understand that natural selection favors the organisms that are better suited to survive in a given environment (8.a) • Understand that a great diversity of species increases the chance that at least some organisms survive major changes in the environment (8.b) • Relate the effects of genetic drift on the diversity of organisms in a population (8.c) • Understand the influence of reproductive or geographic isolation on speciation (8.d) P Page 6 of 10 Revised May 2008 • Demonstrate how to analyze fossil evidence with regard to biological diversity, episodic speciation, and mass extinction (8.e) Required Lab: Bird Beak Lab Physiology (Homeostatis) 9. Students understand that as a result of the coordinated structures and functions of organ systems, the internal environment of the human body remains relatively stable (homeostatic) despite changes in the outside environment. P P • • • • Explain how the complementary activity of major body systems (respiratory, circulatory, digestive, & excretory) provides cells with oxygen and nutrients and removes toxic waste products such as carbon dioxide (9.a) Investigate how the nervous system mediates communication between different parts of the body and the body’s interactions with the environment (9.b) Demonstrate how feedback loops in the nervous and endocrine systems regulate conditions in the body (9.c) Understand the functions of the nervous system (9.d1) Diagram how neurons transmit electrochemical impulses (9.d2) Diagram the pathway of impulses in sensation, thought, and response (includes sensory neurons, interneurons, and motor neurons) (9.e1) Required Lab: Senses Lab Physiology (Infection & Immunity) 10. Students understand how organisms have a variety of mechanisms to combat disease. • Recognize the role of the skin in providing non-specific defenses against infection (10.a) Page 7 of 10 Revised May 2008 • Trace the role of antibodies in the body’s response to infection (10.b) • Describe how vaccination protects an individual from infectious diseases. (10.c1) • Interpret a graph showing the body’s production of antibodies in response to infection (10.c2) P Compare and contrast bacteria and viruses. (10.d) • Explain why an individual with a compromised immune system (i.e., a person with AIDS) may be unable to fight off and survive infections by microorganisms that are usually benign (10.e) Required Lab: HIV Transmission Demo Page 8 of 10 Revised May 2008 Investigation and Experimentation 11. Investigation and experimentation forms the foundation of science knowledge and is one of the core skills needed for scientific inquiry. It is essential that we teach our students skills and knowledge needed to do scientific inquiry. Science literacy stems from students engaging in appropriate scientific investigations and interpreting new data to form decisions. The scientific process is made-up of asking meaningful questions and conducting engaging investigations. As a basis for understanding this process students will develop their own questions and perform required and recommended lab investigations. P P P P P P P P P P P Select and use appropriate tools and technology (such as computer-linked probes, spreadsheets, graphing calculators, rulers, protractors, and balances) to perform tests, collect data, analyze relationships, and display data (11.a) Identify and communicate sources of unavoidable experimental error (11.b) Identify possible reasons for inconsistent results, such as sources of error or uncontrolled conditions (11.c) Formulate explanations by using logic and evidence (11.d) Distinguish between hypothesis and theory as scientific terms (11.f) Recognize the usefulness and limitations of models and theories as scientific representations of reality (11.g) Analyze the locations, sequences, or time intervals that are characteristic of natural phenomena (e.g., relative ages of rocks, locations of planets over time, and succession of species in an ecosystem) (11.i) Recognize the issues of statistical variability and the need for controlled tests (11.j) Recognize the cumulative nature of scientific evidence (11.k) Analyze situations and solve problems that require combining and applying concepts from more than one area of science (11.l) Investigate a science-based societal issue by researching the literature, analyzing data, and communicating the findings. Examples of issues include irradiation of food, cloning of animals by somatic cell nuclear transfer, choice of energy sources, and land and water use decisions in California (11.m) Page 9 of 10 Revised May 2008 P Know that when an observation does not agree with an accepted scientific theory, the observation is sometimes mistaken or fraudulent (e.g., Piltdown Man fossil or unidentified flying objects), and that the theory is sometimes wrong (e.g., Ptolomaic model of the movement of the Sun, Moon and planets) (11.n) Page 10 of 10 Revised May 2008