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Transcript
Human Immune Function Evaluation Tools The immune system is a key protection system against hazardous foreign substances. Proper functioning of the immune system can be monitored by evaluating the antibody response to foreign antigens. However, immune function is affected by a variety of exogenous environmental agents (e.g. infectious bacteria and virus), drugs (e.g. immunosuppressants and immunomodulators), and intrinsic factors (e.g. stress, GI disorders and aging associated with immuno-senescence). The consequence of lowered immune function may increase health risks such as susceptibility to diseases causative pathogens. To measure immune function, Chondrex provides antibody ELISA kits to determine IgA and IgG antibody levels to various types of pathogenic and non-pathogenic environmental factors (Table 1). This series of ELISA kits employ the ChonBlock® buffer system (ref paper), which eliminates non-specific reactions, as well as ionic interactions in indirect ELISAs to provide accurate assay results. Chondrex also provides ChonBlock® buffer for in-house use for individual assay purposes (Table 2). Please contact us for more information at [email protected]. Table 1 - Human Antibody Assay KitsPreve Product Antigen Isotypes Bacteria Human Anti-E. coli Antibody Assay Kit E. coli (O111:B4): Heat Killed Lactobacillus casei: Heat Killed Staphylococcus aureus: Heat Killed IgA & IgG Human Anti-LPS Antibody Assay Kit LPS from E. coli (O-111:B4) IgA & IgG Human Anti-Pg-LPS Antibody Assay Kit LPS from Porphyromonas gingivalis (Pg-LPS) IgA & IgG Human Anti-SEB Antibody Assay Kit SEB from Staphylococcus aureus IgA & IgG Human Anti-PG-PS Antibody Assay Kit Proteoglycan Polysaccharides (PG-PS) from Streptococcus pyogenes IgA & IgG Human Anti-BSA Antibody Assay Kit Bovine Albumin (BSA) IgA & IgG Human Anti-OVA Antibody Assay Kit Ovalbumin (OVA) IgA & IgG Human Anti-BIgG Antibody Assay Kit Bovine Immunoglobulin G (BIgG) IgA & IgG Human Anti-Lactobacillus Antibody Assay Kit Human Anti-Staphylococcus Antibody Assay Kit IgA & IgG IgA & IgG Bacterial Toxins & Cell Components Dietary Proteins Table 2 - ChonBlock® Buffer System Product Description Blocking Buffer Blocks hydrophobic binding of immunoglobulin to plastic surfaces Sample/Standard Dilution Buffer Blocks hydrophobic binding of immunoglobulin to plastic surfaces No immunological and biological activity No interference with target antibodies and antigens Blocks hydrophobic and ionic binding of detection antibodies to plastic Secondary Antibody Dilution Buffer and target antigen Reduces edge effect 425.702.6365 or 888.246.6373 I www.chondrex.com I 1.0