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CHAPTER SEVEN The Nervous System Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functions of the Nervous System Sensory input—gathering information To monitor changes occurring inside and outside the body Changes = stimuli Integration To process and interpret sensory input and decide if action is needed Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functions of the Nervous System Motor output A response to integrated stimuli The response activates muscles or glands Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functions of the Nervous System Figure 7.1 Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Structural Classification of the Nervous System Central nervous system (CNS) Brain Spinal cord Peripheral nervous system (PNS) Nerves outside the brain and spinal cord Spinal nerves Cranial nerves Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Classification of the Peripheral Nervous System Sensory (afferent) division Nerve fibers that carry information to the central nervous system Motor (efferent) division Nerve fibers that carry impulses away from the central nervous system Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Organization of the Nervous System Figure 7.2 Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Central Nervous System CNS Spinal cord Brain Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functions Integrates Information Processes changes in the internal and external environments Initiates Responses Responds (with the endocrine system) to coordinate and regulate body systems functions to maintain homeostasis body's ability to physiologically regulate its inner environment to ensure its stability in response to changes in the outside environment Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Major parts of the brain Brain Stem Cerebellum-coordination Cerebrum Frontal-processing Parietal-movement Occipital-vision Temporal-hearing Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Frontal View Corpus Callosum connector Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Cerebrum Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Protection of the Central Nervous System Scalp and skin Skull and vertebral column Meninges Cerebrospinal fluid (CSF) Blood-brain barrier Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Protection of the Central Nervous System Figure 7.17a Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Meninges Dura mater Double-layered external covering Periosteum—attached to inner surface of the skull Meningeal layer—outer covering of the brain Folds inward in several areas Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Meninges Dura Arachnoid Pia Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Meninges Arachnoid layer Middle layer Web-like Pia mater Internal layer Clings to the surface of the brain Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Meninges Figure 7.17b Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Cerebrospinal Fluid (CSF) Similar to blood plasma composition Formed by the choroid plexus Forms a watery cushion to protect the brain Circulated in arachnoid space, ventricles, and central canal of the spinal cord Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Ventricles and Location of the Cerebrospinal Fluid Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Ventricles and Location of the Cerebrospinal Fluid Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Cerebrospinal Fluid (CSF) bring nutrients to nerves and to remove waste products Similar to Lymph Fluid act as a cushion for CNS made in choroid plexus in the brain sinuses or Ventricles Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Pathology - Hydrocephalus buildup of too much cerebrospinal fluid in the brain too much fluid puts harmful pressure on your brain – intracranial pressure can permanently damage the brain problems with physical and mental development Place shunt in brain to drain excess fluid Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Hydrocephalus in a Newborn Hydrocephalus CSF accumulates and exerts pressure on the brain if not allowed to drain Figure 7.19 Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings ―Water on the Brain‖ Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Blood-Brain Barrier Includes the least permeable capillaries of the body Excludes many potentially harmful substances Useless as a barrier against some substances Fats and fat soluble molecules Respiratory gases Alcohol Nicotine Anesthesia Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Traumatic Brain Injuries Concussion Slight brain injury No permanent brain damage Contusion Nervous tissue destruction occurs Nervous tissue does not regenerate Cerebral edema Swelling from the inflammatory response May compress and kill brain tissue Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Cerebrovascular Accident (CVA) Commonly called a stroke The result of a ruptured blood vessel supplying a region of the brain Brain tissue supplied with oxygen from that blood source dies Loss of some functions or death may result Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Alzheimer‘s Disease Progressive degenerative brain disease Mostly seen in the elderly, but may begin in middle age Structural changes in the brain include abnormal protein deposits and twisted fibers within neurons Victims experience memory loss, irritability, confusion, and ultimately, hallucinations and death Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Pathology - Meningitis Swelling & inflammation of membranes covering the brain affecting Cerebrospinal Fluid (CSF) Usually caused by an infection does have meningitis, the cerebrospinal fluid will be Major reason for a spinal tap or lumbar puncture Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Spinal Tap or Lumbar Puncture Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Bacteria in CSF Cerebrospinal fluid from a patient with meningitis. The bacteria are streptococci, found in pairs. Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Multiple Sclerosis - MS Scleroses = scars; plaques or lesions that form in the nervous system. most commonly involves white matter areas close to the ventricles, cerebellum, brain stem, optic nerve. function of white matter cells is to carry signals between grey matter areas, where the processing is done. Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Myelin Sheath – nerve covering Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings MRI of MS Patient Typically white females between 20 and 40 Acute and Progressive stages Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nerve damage can cause: Weakness or Numbness Weakness in an arm or leg Loss of balance Muscle spasms leads to frequent tripping or difficulty walking Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings – inflammation of the optic nerve many times the first sign blurred vision, loss of color vision, eye pain, or blindness, usually in one eye usually temporary Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings The toll MS takes ……. Mental difficulties mild memory loss or trouble concentrating Loss of bladder control Fatigue tired even after a good night‘s sleep. Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Treatment Treat symptoms – no ‗cure‘ Support patient functioning Physical therapy Massage therapy Chiropractic Medications Interferon corticosteroids Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Trephination Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Classification of the Peripheral Nervous System Motor (efferent) division (continued) Two subdivisions Somatic nervous system = voluntary Autonomic nervous system = involuntary Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells Figure 7.3e Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons Cell body Nucleus Large nucleolus Processes outside the cell body Dendrites—conduct impulses toward the cell body Axons—conduct impulses away from the cell body Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons Axons end in axonal terminals Axonal terminals contain vesicles with neurotransmitters Axonal terminals are separated from the next neuron by a gap Synaptic cleft—gap between adjacent neurons Synapse—junction between nerves Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons Myelin sheath—whitish, fatty material covering axons Schwann cells—produce myelin sheaths in jelly roll–like fashion Nodes of Ranvier—gaps in myelin sheath along the axon Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Classification of Neurons Sensory (afferent) neurons Carry impulses from the sensory receptors to the CNS Cutaneous sense organs Proprioceptors—detect stretch or tension Motor (efferent) neurons Carry impulses from the central nervous system to viscera, muscles, or glands Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Neuron Classification Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Structural Classification of Neurons Multipolar neurons—many extensions from the cell body Figure 7.8a Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Structural Classification of Neurons Bipolar neurons—one axon and one dendrite Figure 7.8b Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Structural Classification of Neurons Unipolar neurons—have a short single process leaving the cell body Figure 7.8c Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Properties of Neurons Irritability Ability to respond to stimuli Conductivity Ability to transmit an impulse Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings The Reflex Arc Reflex—rapid, predictable, and involuntary response to a stimulus Occurs over pathways called reflex arcs Reflex arc—direct route from a sensory neuron, to an interneuron, to an effector Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Simple Reflex Arc Sensory receptors (stretch receptors in the quadriceps muscle) Sensory (afferent) neuron Sensory receptors (pain receptors in the skin) Spinal cord Sensory (afferent) neuron Synapse in ventral horn gray matter Interneuron Motor (efferent) neuron Motor (efferent) neuron (b) Effector (quadriceps muscle of thigh) Effector (biceps brachii muscle) (c) Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Types of Reflexes and Regulation Somatic reflexes Activation of skeletal muscles Example: When you move your hand away from a hot stove Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Types of Reflexes and Regulation Autonomic reflexes Smooth muscle regulation Heart and blood pressure regulation Regulation of glands Digestive system regulation Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Types of Reflexes and Regulation Patellar, or knee-jerk, reflex is an example of a two-neuron reflex arc Figure 7.11d Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Spinal Cord Extends from the foramen magnum of the skull to the first or second lumbar vertebra 31 pairs of spinal nerves arise from the spinal cord Cauda equina is a collection of spinal nerves at the inferior end Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Spinal Cord Anatomy Figure 7.20 (1 of 2) Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Spinal Cord Anatomy Figure 7.21 Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Pathways Between Brain and Spinal Cord Figure 7.22 Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Peripheral Nervous System (PNS) Nerves and ganglia outside the central nervous system Nerve = bundle of neuron fibers Neuron fibers are bundled by connective tissue Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Structure of a Nerve Figure 7.23 Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Classification of Nerves Mixed nerves Both sensory and motor fibers Sensory (afferent) nerves Carry impulses toward the CNS Motor (efferent) nerves Carry impulses away from the CNS Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Cranial Nerves 12 pairs of nerves that mostly serve the head and neck Only the pair of vagus nerves extend to thoracic and abdominal cavities Most are mixed nerves, but three are sensory only Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Cranial Nerves I Olfactory nerve—sensory for smell II Optic nerve—sensory for vision III Oculomotor nerve—motor fibers to eye muscles IV Trochlear—motor fiber to eye muscles Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Cranial Nerves V Trigeminal nerve—sensory for the face; motor fibers to chewing muscles VI Abducens nerve—motor fibers to eye muscles VII Facial nerve—sensory for taste; motor fibers to the face VIII Vestibulocochlear nerve—sensory for balance and hearing Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Cranial Nerves IX Glossopharyngeal nerve—sensory for taste; motor fibers to the pharynx X Vagus nerves—sensory and motor fibers for pharynx, larynx, and viscera XI Accessory nerve—motor fibers to neck and upper back XII Hypoglossal nerve—motor fibers to tongue Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Distribution of Cranial Nerves Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Differences Between Somatic and Autonomic Nervous Systems Nerves Somatic: one motor neuron Autonomic: preganglionic and postganglionic nerves Effector organs Somatic: skeletal muscle Autonomic: smooth muscle, cardiac muscle, and glands Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Autonomic Nervous System Motor subdivision of the PNS Consists only of motor nerves Also known as the involuntary nervous system Regulates activities of cardiac and smooth muscles and glands Two subdivisions Sympathetic division Parasympathetic division Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Anatomy of the Autonomic Nervous System Figure 7.28 Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Autonomic Functioning Sympathetic—―fight or flight‖ Response to unusual stimulus Takes over to increase activities Remember as the ―E‖ division Exercise, excitement, emergency, and embarrassment Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PNS: Autonomic Functioning Parasympathetic—―housekeeping‖ activites Conserves energy Maintains daily necessary body functions Remember as the ―D‖ division digestion, defecation, and diuresis Copy right © 2009 Pearson Education, Inc., publishing as Benjamin Cummings