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Amino Acids as Protein Building Blocks
Proteins are naturally-occurring biopolymers comprised of
amino acids.
The biological function of proteins is inherent in their three
dimensional structure.
All the information required for correct folding of the protein
into its functional native structure is contained in the
primary sequence of amino acids.
The physical chemical properties of the amino acids
contain the biological information required for folding and
function.
Structure of Ubiquitin
1
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPD
QQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76
By convention the primary sequence of amino acids is listed
left to right from the amino terminus to the carboxyl terminus.
Fundamental Structure of Amino Acids
Amino acids are most logically grouped according to the physical properties
of their side chains.
Aliphatic Amino Acids
Aromatic Amino Acids
Polar Amino Acids
Disulfide Bond Formation
Acidic Amino Acids
Mechanism of Asn/Gln Deamidation
Basic Amino Acids
Representations of Protein Surfaces
R74
D39
R72
K27
E51
D52
E24
R54
D58
R42
K6
K48
E18
E64
K63