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Applied Science University
Faculty: Pharmacy
Department : Pharmaceutical
Chemistry and Pharmacognosy
( Course Syllabus )
CourseTitle
Pharm. Organic Chemistry 1
Coordinator Name
Dr.Adel Ardakani
Credit Hours
3
Lecturer
Dr.Adel Ardakani
Course No.
0905120
Room No.
207
Prerequisite
0203103
Year (semester)
2011-2012 2nd
E-mail
[email protected]
Lec./Lab. Credit
-
Office Hours
Daily 10-11 Thursday1-2
Course Objectives:
To provide the students with an understanding of the behavior of organic compounds, the interaction of the major functional
groups in multifunctional compounds. In addition to that, diferent steps of some drugs synthesis including their mechanism of
reactions will be discussed.
Course Description:
This course is a study of the nomenclature and synthesis of pharmaceutical organic compunds. Clasification of these
compounds, their physical and chemical properties, their methods of preparation, reactivity and mechanisms of reactions of
simple aliphatic and aromatic compounds, alkyl halides, alcohols and ethers, reactions mechanisms: SN1, SN2, E1, E2, SNAr
are discussed, using pharmaceutically important compounds, with focus on stereochemistry.
Intended Learning Outcomes:
Successful completion of this course should lead to the following learning outcomes:
Knowledge and understanding:
1. Have an understanding of organic chemistry principles regarding simple groups.
2. Understand electronic structure of the basic organic groups including the most common functional groups.
3. Understand the common organic reactions and their mechanisms.
4. Understand electronic structure of benzene and its derivatives.
Subject specific skills:
1. To describe detailed mechanisms for common reactions: addition, elimination, substitution, oxidation, reduction and
electrophilic aromatic substitution.
2. To name and draw structures for organic molecules containing carbon and oxygen.
3. To describe sources, preparations and reactions of these substances.
4. To describe properties of organic acids and bases, name these substances, and draw their structures.
5. To predict the outcome of acid-base reactions.
6. To name, draw structures and describe reaction’s mechanism.
7. To describe hybridization for various carbon compounds.
Intellectual skills:
1. Develop critical thinking, problem soving regaring basic organic structures and their importance in every day life.
2. To be able to give systematic names to simple organic compounds.
3. Describe how the shape of a molecule is influenced by atomic hybridization, conformation and stereoisomerism.
4. To achieve an understanding of the behavior of organic compounds and to establish a foundation for studies into
natural and synthetic products of pharmaceutical interest.
5. To acquire an understanding of methods used in synthesis, and mechanism of reactions.
Transferable skills:
1. To discuss bonding in organic molecules, including concepts of valence bond theory, resonance, hybridization, and
molecular orbitals.
2. To understand factors that contribute to the stability of organic molecules.
3. To understand IUPAC rules for naming organic compounds.
4. To understand the concept of stereoisomers.
5. To understand the correlation between physical properties of substances and intermolecular forces.
6. To identify functional groups and correlate reactivity patterns with molecular structure.
7. To start developiung simple synthetic strategies toward target molecules.
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Course Contents:
Week
Topics
Reference
(chapter)
Topic Details
Assessment
1.
2.
3.
Covalent Bonding and Shapes of Molecules.
1.1-1.7
Ch 1 p1
Acids and Bases.
2.1-2.6
Ch 2 p 46
Alkanes and Cycloalkanes.
3.1-3.10
Ch 3 p 69
Alkenes and Alkynes.
4.1-4.4
Ch 4 p 115
Reactions of Alkanes & Alkynes.
5.1-5.11
Ch 5 p 138
Chirality: The Handedness of Molecules.
6.1-6.10
Ch 6 p 180
Quiz /2
Haloalkanes.
7.1-7.9
Ch 7 p 215
2nd /23
Alcohols, Ethers, and Thiols.
8.1-8.6
Ch 8 p 265
Benzene and its Derivatives.
9.1-9.8
Ch 9 p 301
Quiz /2
4.
5.
6.
7.
8.
9.
1st /23
10.
11.
12.
13.
14
15.
16.
FINAL
EXAMINATION
WEEK
Grade Distribution:
Assessment
Grade
Date
- First Exam
23
TBA
- Second Exam
23
TBA
- Assignments (reports, quizzes, homeworks, participation, conduct)
4
Above
- Final Examination
50
TBA
* Make-up exams will be offered for valid reasons. It may be different from regular exams in content and format.
Reading List:
Text Book
Introduction to Organic Chemistry, William Brown and Thomas Poon, John Wiley & Sons, 4 th
edition, 2011, ISBN: 978-0-470-38467-1.
Other
References
1) Organic Chemistry, Graham Solomons and Craig Fryhle, 10 th edition, John Wiley and sons, Inc,
2011, ISBN: 978-0-470-52459-6.
2) Organic Chemistry, David Klein, John Wiley and sons, Inc, 2011, ISBN: 978-0-470-91780-0
Last updated on: 19-1-2011 by: Dr. Adel Ardakani
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