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Biology Mrs. Zhen Human Genetics Review 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. Name: ____________________ Period: ____________________ Date: _____________________ What is the difference between autosomes and sex chromosomes? What are the two types of sex chromosomes? What kinds of sex chromosomes are present in males and females? What is a sex-linked trait? Why are males more likely to be affected by a sex-linked trait? Explain. In fruit flies, eye color is sex-linked and red eye (R) is dominant to white eye (r). A carrier female fruit fly is crossed with a white-eyed male fruit fly. Calculate the genotype and phenotype percentages of their offspring. Hemophilia is a sex-linked genetic disorder. If a child has hemophilia, what can you conclude about his/her mother’s genotype? What is meant by a “carrier”? Give two examples of common sex-linked genetic disorders. What is the purpose of a pedigree? In a pedigree, what is represented by a horizontal line? A half-shaded circle? Roman numerals? (Know how to interpret a pedigree and figure out the genotype of each individual) What is a karyotype? What are the uses of karyotype? (Know how to interpret a karyotype to identify mutations or genetic disorders) What is a mutation? What are some sources of mutagens? At which two levels can mutation occur in the cells? What is the difference between point mutation and frameshift mutation? Give an example of the following mutation: inversion, deletion, and translocation. What is nondisjunction? How can you detect nondisjunction in a karyotype? List three genetic conditions that are results of nondisjunction. ** Use your genetic disorder chart to answer the following questions: (You will be able to use the chart on the test; bring the chart on the test day) 19. Which genetic disorder is caused by a dominant allele? 20. What is the cause of cystic fibrosis? 21. Which two genetic disorders result in deterioration of part of the brain? 22. Which two genetic disorders occur more in particular ethnic populations (i.e. African Americans, Whites)