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Nelson Biology VCE Units 3 & 4 Chapter 8: DNA Structure 1. Inheritance of ________ from parents helps determine the characteristics that make an individual unique, but similar to their parents. 2. Much progress in genetics has occurred as a result of improved knowledge of the chemical nature of the gene. (T/F) 3. Which of the following statements does not apply to the gene? a. b. c. d. It It It It is involved in producing a polypeptide chain. is a segment of DNA. has a specific sequence of nucleotide bases. is attached to a ribosome. 4. Gregor Mendel made a significant contribution to our knowledge of genetics in that he concluded from his breeding experiements that definite __________ are transmitted from parents to offspring. 5. The experiments of Frederick Griffith and Oswald Avery on bacteria showed that hereditary material consisted of nucleic acids, possibly DNA. (T/F) 6. In 1953 the Cambridge scientists James Watson and Francis Crick discovered the structure of the hereditary material DNA without any knowledge of the work of other scientists. (T/F) 7. X-ray diffraction photography helped scientists to work out the structure of the DNA molecule. This technique is very useful for imaging very _______ objects. 8. Watson and Crick suggested that DNA consisted of two chains twisted around each other to form a _________ _______ ladder, cross-linked by nitrogenous bases. 9. The four types of bases in DNA are __________ (A), __________ (C), __________ (G) and __________ (T). 10. The nucleotides that make up the DNA molecule have all of the following characteristics except: a. b. c. they are organic compounds they are proteins they contain either a ribose or deoxyribose sugar d. they contain a phosphate group 11. RNA is similar to DNA in that it consists of nucleotides joined together, however RNA does not contain the nucleotide __________, which is replaced by __________. 12. A nucleotide of DNA is composed of a ____________ sugar group, a __________ group and a ____________ ______. 13. The nitrogenous bases in each rung of the DNA 'ladder' are held together by very strong hydrogen bonds. (T/F) 14. In the DNA molecule, adenine can only bond with __________ and cytosine can only bond with __________. The net result is two long, intertwined chains of _____________. 15. One strand of nucleotides in a DNA molecule runs in the 5-carbon to the 3-carbon direction, while the complementary strand runs in the opposite direction. (T/F) 16. Pairing of bases in DNA is so significant because it allows for the ____________ of genetic information. 17. The sequence of nucleotide bases in DNA is slightly different for members of the same species but very different between members of different species. (T/F) 18. Match the phases of meiosis. a. b. c. d. first phase second phase third phase last phase 1. 2. 3. 4. telophase prophase metaphase anaphase a. b. c. d. 19. Just before a cell divides, the two strands of the DNA double helix unwind and separate, exposing some nucleotide bases. (T/F) 20. During DNA replication, enzymes called DNA _____________ and DNA ___________ help build new complementary strands. DNA __________ help to unzip the DNA molecule to allow transcription to occur. 21. The process of DNA replication ensures that the template strand of DNA is conserved (remains substantially the same) between generations. (T/F) 22. If all the DNA in a normal human body cell was unwound and put end to end it would stretch to the moon and back about one million times. (T/F) 23. The instructions carried in DNA molecules are translated into action through the process of ___________ ___________. 24. All proteins are made up of about 500 amino acids of 20 different types, linked together in exactly the same sequence. (T/F) 25. In the mRNA molecule, combinations of ________ bases, called ________, specify each type of amino acid. 26. Explain how the information contained in the DNA in the nucleus of the cell is transmitted out to the ribosomes (where the proteins are assembled) in the cytoplasm. 27. During normal protein synthesis, information flows from the DNA to the ribosomes and from the ribosomes back to the DNA. (T/F) 28. The process of transcription is very similar to the process of DNA _____________. 29. The coding section of DNA, which is transcribed onto a mRNA molecule, is called a gene. (T/F) 30. Both exons and introns are transcribed into pre-mRNA but ________ must be removed before the mRNA leaves the nucleus. 31. The strand of the DNA molecule which is read during DNA replication and mRNA production is called the __________ strand. 32. When mRNA reaches a ribosome in the cytoplasm, it enables amino acids to be assembled in the correct order for a protein. (T/F) 33. Each of the following statements is true of ribosomes except: a. b. c. d. they they they they are only found in eukaryotic cells consist of proteins combined with ribosomal RNA are found in the cytoplasm of cells are involved in the translation of proteins 34. The organelle responsible for the manufacture of ribosomes is the nucleolus, which is found in the nucleus of cells. (T/F) 35. Transfer RNA (tRNA) carries __________ ______ to the ribosomes in the cytoplasm. 36. An __________ is a triplet of nucleotides at the end of a tRNA molecule which is complementary to a triplet codon on the mRNA. 37. Match the anticodon messages with the appropriate codon on the messenger RNA. a. b. c. d. UGA UUU CCA GCG 1. 2. 3. 4. GGU AAA CGC ACU (codes for amino acid threonine) a. b. c. d. 38. A protein molecule is assembled at the __________ as many amino acids are joined together to make polypeptide chains. 39. A large amount of energy is used by the body in the manufacture of proteins by the ribosomes. (T/F) 40. Some codons do not code for a particular amino acid, instead they stop the production of a polypeptide at a ribosome at a particular point. These codons are called ______ codons. 41. Cells do not express all their genes at the same time. Gene expression seems to be dependent on the type of cell, its stage of ____________, and the _____________ of the cell. 42. Many experiments (such as those carried out by Jacob and Monod in the late 1950s) indicate that many structural genes have promotor regions close to them on the DNA strand which can 'switch' the gene on and off. (T/F)