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GENETICS BIOL 3413.01 Time: TR 9:25-10:40 Room: HSHSW 1.402 FALL 2016 Instructor: Office: Office Hours: Text: Dr. S. J. Gunn SCIE 1.360 665-3540 [email protected] MW 9:00-10:00 am, TR 10:45-11:45 am, or by appointment An Introduction to Genetic Analysis. 2012 A.F.J. Griffiths, S.R. Wessler, S. B. Carroll and J. Doebley. 11th Edition. W.H. Freeman and Company. The textbook is be available new. Used copies of the 10th Edition will still be fully serviceable for the course. Grading: There will be four lecture exams given, each of which covers the materials from lecture, handouts, problem sets, and assigned readings. Each exam will be worth 100 points. There will be no exemptions from any exams and no exams will be given early. An additional 100 points will be available in the form of graded problem sets and announced or unannounced quizzes. There will be a total of 500 points in the lecture portion of the course. The lecture grade will make up 75% of the final course grade, with the other 25% coming from the laboratory grade. Final grades will be determined on a standard scale (90, 80, 70, 60) with no curve All lecture make up exams will be given during dead days at the end of the semester. The make up will be a generalized, comprehensive make up exam. This will be the only time for make up exams. Late home work will be accepted with a substantial penalty. 25% of the assignment's value is lost for each day late. After 4 days a zero will be recorded. Class: Tardiness will not be tolerated. Be on time!!! There will be no eating, drinking, or smoking during lecture. Questions during lecture are encouraged, however social conversations will not be tolerated. Please turn off or silence all cell phones and beepers during class. Biology Student Learning Outcomes (core curriculum course): Principles of Heredity: Students will be able to o explain Mendel’s principles of inheritance and apply these to problems of inheritance o describe the different forms of inheritance patterns and identify these in genetic data o use and interpret probabilities and statistics in the gathering, predicting, and analysis of genetic data o describe various types of genetic crosses and indicate when/why they would be used by a geneticist o explain more complex modes of inheritance and how sex influences the inheritance and expression of genes (e.g. sex-influenced traits, cytoplasmic inheritance, genomic imprinting) o use this information in predicting genetic outcomes and the analysis of genetic data Cell and Organism Reproduction: Students will be able to o describe cellular and chromosomal events that occur during the eukaryotic cell cycle and gamete formation o describe chromosome behavior and changes in chromosome structure and number as a cell progresses through a cell cycle, meiosis I and meiosis II o explain how meiosis and random fertilization contribute to genetic variation in sexually reproducing organisms Pedigrees: Students will be able to apply principles of heredity in assessment of pedigrees to identify genotypes of family members, conclude the mode of inheritance for a trait, and predict mating outcomes. Eukaryotic Gene Mapping: Students will be able to o compare the effect of linkage and independent assortment on genetic outcomes and assess data to determine if genes are linked or on separate chromosomes o explain how crossing over produces recombination and use recombination frequencies to construct a genetic map o use genetic maps to predict gametic and mating outcomes o describe some of the methods that can be used to place a gene on a particular chromosome (e.g. FISH) Chromosome Variation and Structure: Students will be able to o describe and recognize a variety of abnormalities in chromosome structure and number and explain how these anomalies arise and are detected o explain the molecular structure of chromosomes as it relates to storage, gene expression, and sequence function Nucleic Acid Structure: Students will be able to o describe early studies that led to DNA as the genetic material and/or interpret results from these studies o describe the molecular structure of DNA and RNA and indicate similarities and differences DNA Replication: Students will be able to o describe the historic experiment that demonstrated DNA replication follows a semiconservative model o describe the process of DNA replication in prokaryotes at the biochemical level o explain how proofreading and repair is accomplished during DNA synthesis o describe how DNA is replicated in viruses, plasmids, and eukaryotes and identify similarities and differences between these and replication in prokaryotes Gene Expression: Students will be able to o describe at the biochemical level the events that occur to go from gene to phenotype o identify different types of RNA, note their properties, how they are processed to yield a functional form, and their function in gene expression o recognize the importance of regulating gene expression in prokaryotes and eukaryotes and describe the levels at which gene expression is controlled and the mechanisms used by prokaryotes and eukaryotes Mutations: Students will be able to define and identify the various types of mutations that occur at the DNA and protein levels and explain and recognize the relationship between mutations and new alleles. TENTATIVE LECTURE SCHEDULE Genetics 3413.01 DATE Aug. Sept. Oct. Nov. TOPIC 30 1 6 9 13 15 20 22 27 29 4 6 11 13 18 20 25 27 1 3 8 10 15 Introduction Mendelian Genetics Mendelian Genetics Mendelian Genetics Mitosis and Meiosis Mitosis and Meiosis EXAM I Sex Determination Sex Linkage General Linkage and Crossing Over Gene Mapping Variation in Chromosome Number Variation in Chromosome Structure Chromosome Replication/Fine Structure EXAM II Nucleic Acid Structure and Replication Fine Structure -30iochemical Genetics Bacterial Genetics Genetic Engineering Gene Expression Molecular Aspects of the Gene Mutation EXAM III CHAPTER 1 2 3 6 2 2 2 2 4 4 17 17 7 7 8 5 9 10 10 16 (Nov. 17 is the Drop Date) Dec. 17 22 24 29 1 6 8 15 (Th) Repair Systems Transposable Elements THANKSGIVING HOLIDAYS No Class Gene Regulation in Prokaryotes Gene Regulation in Eukaryotes Extra-chromosomal Inheritance Study Day FINAL EXAM IV 12:00 – 1:45 16 15 11 12 13 STUDENTS WITH DISABILITIES: If you have a documented disability (physical, psychological, learning, or other disability which affects your academic performance) and would like to receive academic accommodations, please inform your instructor and contact Student Accessibility Services to schedule an appointment to initiate services. It is recommended that you schedule an appointment with Student Accessibility Services before classes start. However, accommodations can be provided at any time. Brownsville Campus: Student Accessibility Services is located in Cortez Hall Room 129 and can be contacted by phone at (956) 882-7374 (Voice) or via email at [email protected]. Edinburg Campus: Student Accessibility Services is located in 108 University Center and can be contacted by phone at (956) 665-7005 (Voice), (956) 665-3840 (Fax), or via email at [email protected]. MANDATORY COURSE EVALUATION PERIOD: Students are required to complete an ONLINE evaluation of this course, accessed through your UTRGV account (http://my.utrgv.edu); you will be contacted through email with further instructions. Online evaluations will be available Nov. 18 – Dec. 9, 2015. Students who complete their evaluations will have priority access to their grades. ATTENDANCE: Students are expected to attend all scheduled classes and may be dropped from the course for excessive absences. UTRGV’s attendance policy excuses students from attending class if they are participating in officially sponsored university activities, such as athletics; for observance of religious holy days; or for military service. Students should contact the instructor in advance of the excused absence and arrange to make up missed work or examinations. SCHOLASTIC INTEGRITY: As members of a community dedicated to Honesty, Integrity and Respect, students are reminded that those who engage in scholastic dishonesty are subject to disciplinary penalties, including the possibility of failure in the course and expulsion from the University. Scholastic dishonesty includes but is not limited to: cheating, plagiarism, and collusion; submission for credit of any work or materials that are attributable in whole or in part to another person; taking an examination for another person; any act designed to give unfair advantage to a student; or the attempt to commit such acts. Since scholastic dishonesty harms the individual, all students and the integrity of the University, policies on scholastic dishonesty will be strictly enforced (Board of Regents Rules and Regulations and UTRGV Academic Integrity Guidelines). All scholastic dishonesty incidents will be reported to the Dean of Students. SEXUAL HARASSMENT, DISCRIMINATION, and VIOLENCE: In accordance with UT System regulations, your instructor is a “responsible employee” for reporting purposes under Title IX regulations and so must report any instance, occurring during a student’s time in college, of sexual assault, stalking, dating violence, domestic violence, or sexual harassment about which she/he becomes aware during this course through writing, discussion, or personal disclosure. More information can be found at www.utrgv.edu/equity, including confidential resources available on campus. The faculty and staff of UTRGV actively strive to provide a learning, working, and living environment that promotes personal integrity, civility, and mutual respect in an environment free from sexual misconduct and discrimination. COURSE DROPS: According to UTRGV policy, students may drop any class without penalty earning a grade of DR until the official drop date. Following that date, students must be assigned a letter grade and can no longer drop the class. Students considering dropping the class should be aware of the “3-peat rule” and the “6-drop” rule so they can recognize how dropped classes may affect their academic success. The 6-drop rule refers to Texas law that dictates that undergraduate students may not drop more than six courses during their undergraduate career. Courses dropped at other Texas public higher education institutions will count toward the six-course drop limit. The 3-peat rule refers to additional fees charged to students who take the same class for the third time.