Download Matching – Each question is worth 0.5 pt

MICROBIO320
Name____________________________
Study Guide Questions - 15 pts total
Below are examples of the different types of questions that will be asked on Exam 1.
The only type of question not included in these examples is an essay question.
Short Answers – These should be typically 1-2 sentence answers.
1. Indicate two (2) reasons for increased life expectancy and indicate why they have resulted in
increased longevity. (1 pt)
2. Name two functions attributed to complement activation. (1 pt)
3. Name two cell types of the myeloid lineage (1 pt)
Matching – Each question is worth 0.5 pt
Choose the best answer from the following list: there may be more than 1 correct answer.
IgM
IgD
IgG
IgE
IgA
4. Best activator of the classical complement pathway. __________________
5. The LEAST abundant isotype found in serum. ________________
6. The secreted form is found in serum after an initial exposure to a pathogen. ______________
7. Plays a primary role in protecting against pathogens that infect through the respiratory and
gut mucosa. _____________
True / False – 1 pt each
8. ______ The invariant chain occupies the MCH Class II binding groove until peptide is loaded
in the endosomal/ exocytic fusion vesicle.
9. ______ Phagocytic cells participate in both the Innate and Adaptive immune responses.
10._____ Skin is the largest anatomical barrier (surface area) of our non-specific innate
immune defenses.
Multiple choice - Pick the best answer
Which of the following cells ARE NOT considered professional antigen presenting cells? (0.5 pt)
A.
B.
C.
D.
E.
B lymphocyctes (B cells)
Natural killer cells
Macrophage cells
Dendritic cells
All of the above
A term used when Ig molecules coat the surface of a microbe and enhances phagocytosis. (0.5 pt)
A.
B.
C.
D.
E.
Complement fixation
Neutralization
Opsonization
Endocytosis
All of the above
The antigen binding specificity of an antibody is due to: (0.5 pt)
A.
B.
C.
D.
E.
the constant regions of the light chains
the variable framework regions of the heavy & light chains
the variable regions of the heavy chains
the hypervariable regions of both heavy & light chains
All of the above
The following are considered humoral components of our non-specific Innate Immunity defense
(0.5 pt)
A.
B.
C.
D.
E.
Lysozyme.
Complement.
Sweat.
Defensins.
All of the above.
Which of the following statements is INCORRECT concerning antigen-specific receptors on B
cells? (0.5 pt)
A.
B.
C.
D.
E.
They are clonally distributed transmembrane molecules.
They have extensive cytoplasmic domains that interact with intracellular molecules.
They consist of polypeptides with variable and constant regions.
They are associated with signal transduction molecules at the cell surface.
They can interact with peptides derived from non-self antigens.
MHC class I molecules are important for which of the following? (0.5 pt)
A.
B.
C.
D.
E.
binding to CD8 molecules on T cells
presenting exogenous antigen (e.g., bacterial protein) to B cells
binding to Ig on B cells
binding to CD4 molecules on T cells
None of the above
Complete the following Diagram of B Cell DNA Gene rearrangement (4 pts)
The final Mature B cell will display IgA1 immunoglobulin with V3D1J2 specificity.
How many individual rearrangement steps will be required to produce this heavy chain?
Think about this!
Germline B Cell DNA
V 1 V2 V3 V4 V5 V6
~40 V genes
Vn
D1 D2 D3 Dn J1 J2
~25 D genes
Jn
C C C C C C C C C
6 J genes
Diagram the very first step in producing this immunoglobulin
Diagram Final mature B cell DNA structure.
How many steps will be required to produce this heavy chain?
Outline the steps if helpful – this way you might also get partial credit rather than just guessing
at the number.