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Transcript
Shier, Butler, and Lewis: Hole’s Human Anatomy and Physiology, 10 th ed. Chapter 3: Cells Chapter 3: Cells I. Introduction A. An adult human body consists of about ________________________________ cells. B. There are at least _________________________________________ varieties of cells. C. Cells are measured in units called __________________________________________ D. A micrometer equals ____________________________________________________ E. A human egg cell is about ______________________________________ in diameter. F. A red blood cell is about _______________________________________ in diameter. G. Typically the shape of a cell makes possible its _______________________________ II. A Composite Cell A. Introduction 1. It is not possible to describe a typical cell because _______________________ __________________________________________________________________ 2. A composite cell includes __________________________________________ 3. The three major parts of a cell are ____________________________________ __________________________________________________________________ 4. The nucleus is enclosed by _________________________________________ 5. The nucleus contains ______________________________________________ 6. The cytoplasm is _________________________________________________ 7. The cell membrane surrounds _______________________________________ 8. Specialized structures within the cytoplasm are called ____________________ __________________________________________________________________ 9. Cytosol is _______________________________________________________ B. Cell Membrane 1. General Characteristics a. The cell membrane controls ___________________________________ b. The cell membrane is called selectively permeable because __________ ____________________________________________________________ c. Signal transduction is ________________________________________ 3-1 2. Membrane Characteristics a. The cell membrane is mainly composed of _______________________ ____________________________________________________________ b. The cell membrane has a double layer of ________________________ c. The surfaces of the cell membrane are formed by __________________ ____________________________________________________________ d. The interior of the cell membrane is formed by ___________________ ____________________________________________________________ e. The phospholipid bilayer is permeable to ________________________ ____________________________________________________________ f. The phospholipid bilayer is not permeable to _____________________ ____________________________________________________________ g. ____________________________ help to stabilize the cell membrane. h. Five types of membrane proteins are ____________________________ ____________________________________________________________ i. Receptor proteins function to __________________________________ j. Integral proteins function to ___________________________________ ____________________________________________________________ k. Enzymes of the membrane function in __________________________ l. Cellular adhesion molecules function to __________________________ m. Cell surface proteins function to _______________________________ 3. Intercellular Junctions a. Intercellular junctions connect _________________________________ b. Three types of intercellular junctions are_________________________ ____________________________________________________________ c. Tight junctions are located in cells that __________________________ d. Tight junctions function to ____________________________________ e. Desmosomes are located in cells of _____________________________ f. Desmosomes function to _____________________________________ g. Gap junctions are located in cells of the _________________________ ____________________________________________________________ 3-2 h. Gap junctions function to _____________________________________ ____________________________________________________________ 4. Cellular Adhesion Molecules a. Two examples of CAMs are __________________________________ b. Selectin functions to _________________________________________ c. Integrin functions to _________________________________________ ____________________________________________________________ C. Cytoplasm 1. The cytoskeleton is _______________________________________________ 2. The structure of endoplasmic reticulum is ______________________________ __________________________________________________________________ 3. The function of endoplasmic reticulum is ______________________________ __________________________________________________________________ 4. Rough endoplasmic reticulum is studded with __________________________ 5. The ribosomes are sites of __________________________________________ 6. Proteins move from the ER to the ____________________________________ 7. Smooth endoplasmic reticulum is ____________________________________ 8. SER contains enzymes that _________________________________________ __________________________________________________________________ 9. Two places ribosomes are found are __________________________________ 10. Ribosomes are composed of _______________________________________ 11. Ribosomes are the sites of _________________________________________ 12. The structure of the Golgi apparatus is _______________________________ __________________________________________________________________ 13. The Golgi apparatus functions to ____________________________________ __________________________________________________________________ 14. Vesicle trafficking is _____________________________________________ 15. The structure of mitochondria is ____________________________________ __________________________________________________________________ 16. The two layers of a mitochondrion are _______________________________ __________________________________________________________________ 3-3 17. Cristae are _____________________________________________________ 18. Mitochondria function to __________________________________________ __________________________________________________________________ 19. Lysosomes function to ____________________________________________ 20. Lysosomes contain _______________________________________________ 21. Peroxisomes contain _____________________________________________ 22. Peroxisomes are most abundant in a cell of the _________________________ and ______________________________________________________________ . 23. The enzymes of peroxisomes function to _____________________________ __________________________________________________________________ 24. The structure of a centrosome is ____________________________________ 25. A centrosome is usually located near the ______________________________ 26. Centrosomes function to __________________________________________ 27. The structure of a cilium is ________________________________________ 28. The function of cilia is ____________________________________________ 29. The structure of a flagellum is ______________________________________ 30. The function of flagella are ________________________________________ 31. Vesicles are ____________________________________________________ 32. Vesicles are formed by____________________________________________ __________________________________________________________________ 33. Vesicles function to ______________________________________________ 34. Microfilaments are _______________________________________________ 35. Microfilaments cause _____________________________________________ 36. Microtubules are ________________________________________________ 37. Three functions of microtubules are _________________________________ __________________________________________________________________ 38. Inclusions are ___________________________________________________ D. Cell Nucleus 1. The nucleus contains ______________________________________________ 2. Chromosomes are_________________________________________________ 3. The nucleus is enclosed by _________________________________________ 3-4 4. Nuclear pores are _________________________________________________ 5. ________________________________________ move through nuclear pores. 6. Nucleoplasm is ___________________________________________________ 7. Two structures found in nucleoplasm are ______________________________ __________________________________________________________________ 8. The nucleolus is composed of _______________________________________ 9. The nucleolus is the site of__________________________________________ 10. Chromatin is ____________________________________________________ III. Movements Into and Out of the Cell A. Introduction 1. The cell membrane controls _________________________________________ 2. Four types of physical processes are __________________________________ __________________________________________________________________ 3. Three types of physiological mechanisms are ___________________________ __________________________________________________________________ B. Diffusion 1. Diffusion is______________________________________________________ 2. A concentration gradient is _________________________________________ 3. Diffusional equilibrium is __________________________________________ 4. Substances diffuse ____________________________ a concentration gradient. 5. Two conditions that allow a substance to diffuse across a membrane are______ __________________________________________________________________ 6. In body cells, oxygen usually diffuses ________________________ a body cell and carbon dioxide diffuses _________________________________ a body cell. 7. A physiological steady state is _______________________________________ __________________________________________________________________ 8. Five substances that cross the cell membrane through simple diffusion are ____ __________________________________________________________________ 9. The three most important factors that influence diffusion rate are ___________ __________________________________________________________________ 3-5 10. In general, diffusion is more rapid over _______________________ distances, ______________ concentration gradients, and at ______________ temperatures. C. Facilitated Diffusion 1. Facilitated diffusion requires ________________________________________ 2. Substances that move across the cell membrane through facilitated diffusion are __________________________________________________________________ 3. The hormone ___________________ promotes facilitated diffusion of glucose. D. Osmosis 1. Osmosis is ______________________________________________________ 2. Osmotic pressure is _______________________________________________ 3. Water always tends to diffuse toward solutions of _______________________ __________________________________________________________________ 4. Isotonic solutions are ______________________________________________ 5. Hypertonic solutions are ___________________________________________ 6. Hypotonic solutions are ____________________________________________ 7. Cells ________________________________________ in hypertonic solutions. 8. Cells ________________________________________ in hypotonic solutions. E. Filtration 1. The process of forcing molecules through a membrane is _________________ 2. Filtration is commonly used to separate _______________________________ 3. In the body the force for filtration is produced by ________________________ F. Active Transport 1. Movement against a concentration gradient is___________________________ 2. Active transport is similar to facilitated diffusion because _________________ __________________________________________________________________ 3. Substances that move across the cell membrane through active transport are __________________________________________________________________ 4. Active transport requires cellular _____________________________________ G. Endocytosis 1. Endocytosis is the process of ________________________________________ 2. Exocytosis is ____________________________________________________ 3-6 3. Three forms of endocytosis are ______________________________________ __________________________________________________________________ 4. Pinocytosis is endocytosis of ________________________________________ 5. Phagocytosis is endocytosis of_______________________________________ 6. Phagocytes are ___________________________________________________ 7. Receptor-mediated endocytosis moves ________________________________ into the cell. 8. In receptor-mediated endocytosis, a substance must bind to a ______________ before it can enter the cell. 9. A ligand is ______________________________________________________ 10. An example of a molecule that moves into a cell through receptor-mediated endocytsosis is _____________________________________________________ H. Exocytosis 1. Exocytosis is the reverse of _________________________________________ 2. Cells secrete _____________________________________ through exocytosis. 3. Nerve cells secrete ________________________________ through exocytosis. I. Transcytosis 1. Transcytosis moves substances ______________________________________ 2. A virus that uses transcytosis to infect humans is the _____________________ IV. The Cell Cycle A. Introduction 1. The cell cycle is __________________________________________________ 2. Daughter cells are ________________________________________________ 3. The four phases of the cell cycle are __________________________________ __________________________________________________________________ B. Interphase 1. During interphase, a cell ___________________________________________ 2. The phases of interphase are ________________________________________ 3. During the S phase, the cell is _______________________________________ 4. During the G phases, the cell is ______________________________________ 3-7 C. Mitosis 1. Mitosis is _______________________________________________________ 2. In mitosis, the resulting daughter cells are______________________________ 3. At the end of mitosis, each resulting daughter cell has ________ chromosomes. 4. Meiosis is _______________________________________________________ 5. The division of nuclear material is called ______________________________ 6. The division of cytoplasm is ________________________________________ 7. The four stages of mitosis are _______________________________________ __________________________________________________________________ 8. In prophase, centrioles move ________________________________________ 9. In prophase, the nuclear envelope ____________________________________ 10. In prophase, microtubules form _____________________________________ 11. In prophase, chromatin condenses into _______________________________ 12. Centromeres are _________________________________________________ 13. In metaphase, spindle fibers attach to ________________________________ __________________________________________________________________ 14. In metaphase, the chromosomes align ________________________________ 15. In anaphase, the ___________________________ of the chromatids separate. 16. In anaphase, chromosomes move toward _____________________________ 17. Telophase begins when ____________________________________________ 18. In telophase, a nuclear envelope ____________________________________ 19. In telophase, chromosomes begin to _________________________________ D. Cytoplasmic Division 1. Cytoplasmic division begins in ______________________________________ and ends in _______________________________________________________ . 2. ______________________ are responsible for pinching the cytoplasm in half. 3. The resulting daughter cells have identical ____________________________ , but they may vary ___________________________________________________ V. Control of Cell Division A. Three cell types that divide continually are __________________________________ ________________________________________________________________________ 3-8 B. Cells of the liver divide __________________________________________________ C. In laboratory conditions, cells divide _______________________________________ D. Telomeres are _________________________________________________________ E. When chromosome tips wear down, a cell ___________________________________ F. Two types of proteins called _________________________ also control cell division. G. When a cell becomes too large to obtain nutrients, it is likely to __________________ H. Two examples of external controls that influence cell division are ________________ ________________________________________________________________________ I. Hormones are __________________________________________________________ J. Growth factors are ______________________________________________________ K. Contact inhibition prevents _______________________________________________ L. A tumor results ________________________________________________________ M. A benign tumor is ______________________________________________________ N. A malignant tumor is____________________________________________________ O. Two types of genes that cause cancer are ____________________________________ P. Apoptosis is ___________________________________________________________ VI. Stem and Progenitor Cells A. A stem cell divides mitotically to produce ___________________________________ ________________________________________________________________________ B. A progenitor cell is _____________________________________________________ C. A neural stem cell gives rise to ___________________________________________ , but not __________________________________________________________________ D. A totipotent cell can give rise to ___________________________________________ E. Pluripotent cells are _____________________________________________________ F. Cells specialize by ______________________________________________________ 3-9