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Central Nervous System and Epidermis Neurulation What are the major derivatives of the ectoderm? Neurulation What is the difference between primary and secondary neurulation? Primary Neurulation What are the major events of primary neurulation? Primary Neurulation What is involved in the shaping of the neural plate? Primary Neurulation What is responsible for the bending of the neural plate? Primary Neurulation How does neural tube closure compare in birds and mammals? Primary Neurulation What causes spina bifida and anencephaly in human development? Primary Neurulation What allows the neural tube to separate from the overlying ectoderm? Secondary Neurulation Where can secondary neurulation be seen? Neural Tube Differentiation Differentiation occurs on three levels gross anatomical tissue changes bulges and constrictions parts of brain and spinal cord rearrangements of different cell populations forms functional regions cellular changes neurons glial cells Anatomical Differentiation Tissue Differentiation What appears to be responsible for ventral patterning of neural tube? How can this been demonstrated experimentally? Tissue Differentiation What appears to be responsible for dorsal patterning of neural tube? Tissues of the CNS What are the three major layers formed in the spinal cord and medulla? Tissues of the CNS Tissues of the CNS How is the cerebellum organized? Tissues of the CNS How is the cerebrum organized? Tissues of the CNS How do we know that neural stem cells exist in the adult brain? Vertebrate Eye What inductive event initiates eye formation? Vertebrate Eye Into what type of structure does the neural retina differentiate? Vertebrate Eye How does cornea and lens differentiate? Epidermis Epidermis develops from outer ectodermal cells first 2 layers form periderm basal layer then 5 layers form Epidermis What growth factors are involved in epidermal development? Cutaneous Appendages How do cutaneous appendages such as hair, scales, feathers and glands form? Cutaneous Appendages What is known about the genetic control of hair formation? Cutaneous Appendages