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Gastrulation and Neurulation
(3rd and 4th Week of Human Development)
Gametogenesis of Germ Cells in the Male and Female
Summary of the Ovarian Cycle, Fertilization and
Human Development during the First Week
Cleavage and Implantation
http://www.pbs.org/wgbh/nova
/miracle/program.html
Implantation of the Blastocyst (Day 7)
By 9 Days, the Embryo is Completely Implanted
in the Uterine Endometrium
Days 10-13 of Embryonic Development
Day 15 of Embryonic Development
Implantation: Days 7-14
Days 7-9
Days 12-14
Days 10-12
View of the Germ Disc at the End of the
Second Week of Development
Gastrulation: Formation of Embryonic
Mesoderm and Endoderm
Paths of Migration of the Ingressing Mesoderm
Formation of Notochordal Process
Differentiation of Mesoderm
Paraxial mesoderm
Axial skeleton
Voluntary muscles
Intermediate mesoderm
Urinary system
Part of the genital system
Lateral plate mesoderm
Parts of the limbs
Most of the dermis
Formation of Somites from Paraxial Mesoderm
1-7 Somitomeres give rise to the striated muscles of the face, jaw and throat
Remaining 30 give rise to axial skeleton and voluntary muscles of the neck,
body wall and limbs.
Gastrulation
http://www.pbs.org/wgbh/nova
/miracle/program.html
Onset of Neurulation
Neurulation: Formation of the Neural Tube
Closure of the Neural Tube (Day 22)
Closure of the Neural Tube proceeds Bilaterally
Malformations of Neural Tube Closure
(1 in 600 births)
Types of Spina Bifida
Neurulation: Formation of the Neural Tube
Neural Crest Derivatives
Review
Events of Third Week
Gastrulation, Formation of Trilaminar Disc and Initial
Development of the Somites and Neural Tube
Events of Fourth Week
Differentiation of the Somites and the Nervous System
Remnants of the Primitive Streak may Persist and give
rise to a Sacrococcygeal Teratoma (1 in 35,000
newborns)
Derivatives of the Three Germ Cell Layers
Endoderm Derivatives
Epithelium of GI tract and its associated glands as well as glandular cells of the liver and pancreas
Epithelium of the urachus and urinary bladder
Epithelium of respiratory passages; the pharynx, trachea, bronchi, and alveoli.
Epithelial parts of the tonsils, thyroid, parathyroids, tympanic cavity, thymus
Epithelial parts of anterior pituitary
Mesoderm Derivatives
Cardiovascular system
Cells of lymphatic system, spleen, adrenal cortex
Skeleton, Striated muscles and smooth muscle coats
Dermis of skin
Connective tissue and vessels associated with organs
Urogenital system (gonads, ducts and accessory glands)
Ectoderm Derivatives
Epidermis of skin, nails, hair, sweat, mammary and, sebaceous glands
CNS, PNS
Retina and lens of eye
Pupillary muscle of the iris (*this is the only muscle of ectodermal origin)
Pineal body, anterior and posterior pituitary, adrenal medulla, melanocytes, schwann cells, odontoblasts