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Transcript
PCB 4233C Immunology CRN 81083 Tuesday and Thursday 2:00- 4:15 Whitaker Hall Room 244 Weekly Schedule of Activities Date Week 1 Session Topics Course Overview Elements of the Immune System Aug 23 -25 Historical Perspective Innate vs Adoptive Immunity Lymphoid System Overview of Antibody and Cell Mediated Immunity Readings & Assignments Chapter 1 Lab Safety and Review of Techniques Quiz: Immunology Terminology Blood Smear and identification of lymphoid cells Define immunity and resistance to disease. Describe the branches of the immune system. Distinguish between a primary and secondary immune response. Compare and contrast innate and acquired immunity. Identify the molecular properties of antigens and their contribution to immune recognition. Define hapten, antigen and epitope. Date Session Topics Week 2 Antibody Structure and Generation of B-cell Diversity Aug 30 – Basic Structure of Immunoglobulins Sept 1 Immunoglobulin Sequencing Studies Immunoglobulin Fine Structure B-Cell Receptor Antigenic determinants on Immunoglobulins Immunoglobulin Classes Monoclonal Antibodies Immunoglobulin Genetics Readings & Assignments Chapter 2 Immunodiffusion Techniques, Precipitation Reactions, Ouchterlony Tests and Forensic Serology Discuss how the structure of immunoglobulins contribute to both their specificity and their effector functions. Explain the basic structure of an antibody molecule. List the five immunoglobulin classes and their biological function Describe organization of Ig genes Describe class switching Define how antibody structure contributes to antibody specificity and effector function Describe how the binding strength of an antibody-antigen is determined. Date Week 3 Sept 6 -8 Session Topics Antigen Recognition by T lymphocytes T Cell diversity Ag processing and MHC antigens MHC gene organization and distribution Regulation of MHC genes MHC genes and Immunoresponsiveness Readings & Assignments Ch 3 Isolation and enumeration of Lymphocytes Quiz: Evaluate immunodiffusion results List the different types of T cells and their function Describe the TCR complex Describe how T cells recognize antigen Distinguish between MHC class I and class II Describe the function of MHC receptors Adopted from Cliff Renk by N Demers Page 1 Fall, 2005 PCB 4233C Immunology CRN 81083 Tuesday and Thursday 2:00- 4:15 Whitaker Hall Room 244 Date Week 4 Sept. 13-15 Session Topics EXAM 1 Lymphocyte markers Readings & Assignments Ch 1-3 Presentation topic and resources due Flow cytometer List the receptors used to identify B & Tcells Describe the use of a flow cytometer in the identification of lymphoid cells Date Session Topics Week 5 Sept. 20-22 B cell Development Maturation and abnormalities Readings & Assignments Ch 4 Lymphocyte stimulation Describe the Development of B cells Discuss the progression of Ig gene rearrangement with B cells Discuss abnormalities in malignant B cells in relation to B cell development Date Session Topics Week 6 Development of T cells Sept. 27-29 Thymus education Positive and negative selection T cell maturation T cell malignancies Readings & Assignments Ch 5 & 6 Agglutination reactions (Blood typing) List the cell surface receptors used to identify T and B cells List type of T cells Describe difference between T cell type and function Describe lymphocyte matuation in tissues List types of T cell malignancies and correlate with normal T cell development Date Week 7 Oct. 4-6 Session Topics T cell mediated immunity Readings & Assignments Presentations draft due ELISA T cell trafficking T cell signaling List the properties of the significant cytokines Describe potential therapeutic uses of cytokines Discuss mechanism involved in T cell cytotoxicity Describe assays to measure T cell function Date Session Topics Week 8 EXAM 2 (trade day for Nov 22) Oct 11-13 Immunity mediated by B cells and Complement system Readings & Assignments Ch 1-6 CH 50 Assay Adopted from Cliff Renk by N Demers Page 2 Fall, 2005 PCB 4233C Immunology CRN 81083 Tuesday and Thursday 2:00- 4:15 Whitaker Hall Room 244 Understand procedures for measuring complement activity Correlate complement levels and activity with clinical syndromes Date Session Topics Week 9 B cell mediated Immunity Oct. 18-20 Ab. Production T ind. and dept antigens Complement Readings & Assignments Ch 7 Bactericidal Assay Components, Activation, Regulation, Deficiencies Compare T and T independent antigens Compare and contrast the classical and alternate complement systems Discuss consequences of Complement activation and deficiences Date Session Topics Week 10 Body/s Defense against infections Oct. 25 -27 Innate Immunity Epithelium Phagocytosis and NK activity Adaptive Immunity TH1 and TH 2 Readings & Assignments Ch 8 Phagocytosis Immunological memory List various components of innate and adaptive immune response Describe pathways involved in inflammation Define immunological memory Describe differences between primary and secondary response Date Week 11 Nov 1 –3 Session Topics EXAM 3 Failure of Body’s Defenses Readings & Assignments Ch 9 Alpha 2 mac Evasion of the immune system by pathogens Inherited and Acquired Immunodeficiencies List possible mechanisms organisms use to evade host defense mechanisms Discuss role of inheritance associated with specific immunodeficiencies List external factors that contribute to immunodeficiencies Date Session Topics Week 12 Overreaction of Immune system Nov 8- 10 Hypersensitivity Reactions Disruption of Healthy tissue by Immune response Autoimmune disease Adopted from Cliff Renk by N Demers Page 3 Readings & Assignments Ch 11 ANA Assay Fall, 2005 PCB 4233C Immunology CRN 81083 Tuesday and Thursday 2:00- 4:15 Whitaker Hall Room 244 Discuss the mechanisms and consequences of the four primary types of hypersensitive reactions. Describe the principal mediators involved in the four primary types of hypersensitivities. Discuss the timing of the reaction in the types of hypersensitivity reactions. Describe the different mechanism involved in T and B tolerance and the role of antigen in each Discuss possible mechanism involved in the development of autoimmune disease Describe differences between systemic and organ specific autoimmunity List specific autoimmune diseases and their immunological origin List detection mechanisms for identifying and treating autoimmune diseases Date Session Topics Week 13 Autoimmune Disease continued Nov. 15 - 17 Manipulation of the Immune system Vaccination Transplantation Immunosuppression Tumor immunogenicity Immunological techniques Readings & Assignments Ch 12 Alpha 2 mac This session will address the following learning objectives: Compare various methods of vaccination listing strengths and weaknesses of each Discuss immunological basis of organ transplantation List mechanisms/ treatments to prevent graft rejection Discuss the concept of immunological surveillance and tumor development Date Week 14 Session Topics Free day (traded for Oct 11) Readings & Assignments Nov 22 -24 Thanksgiving Experience the impact of over satiation and relaxation on comprehension skills Date Session Topics Week 15 Readings & Assignments Oral Presentations and Reveiw Nov 29- Dec 1 Application of immunology principles to specific topics selected by students Date Week 16 Session Topics EXAM 4 Cumulative Final Adopted from Cliff Renk by N Demers Page 4 Readings & Assignments Ch 1-12 and presentations Fall, 2005