Download Weekly schedule of activities and outcomes

PCB 4233C Immunology
CRN 81083
Tuesday and Thursday 2:00- 4:15
Whitaker Hall Room 244
Weekly Schedule of Activities
Date
Week 1
Session Topics
Course Overview
Elements of the Immune System
Aug 23 -25
 Historical Perspective
 Innate vs Adoptive Immunity
 Lymphoid System
 Overview of Antibody and Cell Mediated Immunity
Readings & Assignments
Chapter 1
Lab Safety and Review of
Techniques
Quiz: Immunology Terminology
Blood Smear and identification
of lymphoid cells
Define immunity and resistance to disease.
Describe the branches of the immune system.
Distinguish between a primary and secondary immune response.
Compare and contrast innate and acquired immunity.
Identify the molecular properties of antigens and their contribution to immune recognition.
Define hapten, antigen and epitope.
Date
Session Topics
Week 2 Antibody Structure and Generation of B-cell Diversity
Aug 30 –
 Basic Structure of Immunoglobulins
Sept 1
 Immunoglobulin Sequencing Studies
 Immunoglobulin Fine Structure
 B-Cell Receptor
 Antigenic determinants on Immunoglobulins
 Immunoglobulin Classes
 Monoclonal Antibodies
 Immunoglobulin Genetics
Readings & Assignments
Chapter 2
Immunodiffusion Techniques,
Precipitation Reactions,
Ouchterlony Tests and
Forensic Serology
Discuss how the structure of immunoglobulins contribute to both their specificity and their effector functions.
Explain the basic structure of an antibody molecule.
List the five immunoglobulin classes and their biological function
Describe organization of Ig genes
Describe class switching
Define how antibody structure contributes to antibody specificity and effector function
Describe how the binding strength of an antibody-antigen is determined.
Date
Week 3
Sept 6 -8
Session Topics
Antigen Recognition by T lymphocytes
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T Cell diversity
Ag processing and MHC antigens
MHC gene organization and distribution
Regulation of MHC genes
MHC genes and Immunoresponsiveness
Readings & Assignments
Ch 3
Isolation and enumeration of
Lymphocytes
Quiz: Evaluate immunodiffusion
results
List the different types of T cells and their function
Describe the TCR complex
Describe how T cells recognize antigen
Distinguish between MHC class I and class II
Describe the function of MHC receptors
Adopted from Cliff Renk by N Demers
Page 1
Fall, 2005
PCB 4233C Immunology
CRN 81083
Tuesday and Thursday 2:00- 4:15
Whitaker Hall Room 244
Date
Week 4
Sept. 13-15
Session Topics
EXAM 1
Lymphocyte markers
Readings & Assignments
Ch 1-3
Presentation topic and resources
due
Flow cytometer
List the receptors used to identify B & Tcells
Describe the use of a flow cytometer in the identification of lymphoid cells
Date
Session Topics
Week 5
Sept. 20-22 B cell Development
 Maturation and abnormalities
Readings & Assignments
Ch 4
Lymphocyte stimulation
Describe the Development of B cells
Discuss the progression of Ig gene rearrangement with B cells
Discuss abnormalities in malignant B cells in relation to B cell development
Date
Session Topics
Week 6 Development of T cells
Sept. 27-29  Thymus education
 Positive and negative selection
 T cell maturation
 T cell malignancies
Readings & Assignments
Ch 5 & 6
Agglutination reactions
(Blood typing)
List the cell surface receptors used to identify T and B cells
List type of T cells
Describe difference between T cell type and function
Describe lymphocyte matuation in tissues
List types of T cell malignancies and correlate with normal T cell development
Date
Week 7
Oct. 4-6
Session Topics
T cell mediated immunity
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Readings & Assignments
Presentations draft due
ELISA
T cell trafficking
T cell signaling
List the properties of the significant cytokines
Describe potential therapeutic uses of cytokines
Discuss mechanism involved in T cell cytotoxicity
Describe assays to measure T cell function
Date
Session Topics
Week 8 EXAM 2 (trade day for Nov 22)
Oct 11-13 Immunity mediated by B cells and Complement system
Readings & Assignments
Ch 1-6
CH 50 Assay
Adopted from Cliff Renk by N Demers
Page 2
Fall, 2005
PCB 4233C Immunology
CRN 81083
Tuesday and Thursday 2:00- 4:15
Whitaker Hall Room 244
Understand procedures for measuring complement activity
Correlate complement levels and activity with clinical syndromes
Date
Session Topics
Week 9 B cell mediated Immunity
Oct. 18-20
Ab. Production
 T ind. and dept antigens
Complement

Readings & Assignments
Ch 7
Bactericidal Assay
Components, Activation, Regulation, Deficiencies
Compare T and T independent antigens
Compare and contrast the classical and alternate complement systems
Discuss consequences of Complement activation and deficiences
Date
Session Topics
Week 10 Body/s Defense against infections
Oct. 25 -27 Innate Immunity
 Epithelium
 Phagocytosis and NK activity
Adaptive Immunity
 TH1 and TH 2

Readings & Assignments
Ch 8
Phagocytosis
Immunological memory
List various components of innate and adaptive immune response
Describe pathways involved in inflammation
Define immunological memory
Describe differences between primary and secondary response
Date
Week 11
Nov 1 –3
Session Topics
EXAM 3
Failure of Body’s Defenses
Readings & Assignments
Ch 9
Alpha 2 mac
Evasion of the immune system by pathogens
Inherited and Acquired Immunodeficiencies
List possible mechanisms organisms use to evade host defense mechanisms
Discuss role of inheritance associated with specific immunodeficiencies
List external factors that contribute to immunodeficiencies
Date
Session Topics
Week 12 Overreaction of Immune system
Nov 8- 10
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Hypersensitivity Reactions
Disruption of Healthy tissue by Immune response
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Autoimmune disease
Adopted from Cliff Renk by N Demers
Page 3
Readings & Assignments
Ch 11
ANA Assay
Fall, 2005
PCB 4233C Immunology
CRN 81083
Tuesday and Thursday 2:00- 4:15
Whitaker Hall Room 244
Discuss the mechanisms and consequences of the four primary types of hypersensitive reactions.
Describe the principal mediators involved in the four primary types of hypersensitivities.
Discuss the timing of the reaction in the types of hypersensitivity reactions.
Describe the different mechanism involved in T and B tolerance and the role of antigen in each
Discuss possible mechanism involved in the development of autoimmune disease
Describe differences between systemic and organ specific autoimmunity
List specific autoimmune diseases and their immunological origin
List detection mechanisms for identifying and treating autoimmune diseases
Date
Session Topics
Week 13 Autoimmune Disease continued
Nov. 15 - 17 Manipulation of the Immune system
 Vaccination
 Transplantation
 Immunosuppression
 Tumor immunogenicity
 Immunological techniques
Readings & Assignments
Ch 12
Alpha 2 mac
This session will address the following learning objectives:
Compare various methods of vaccination listing strengths and weaknesses of each
Discuss immunological basis of organ transplantation
List mechanisms/ treatments to prevent graft rejection
Discuss the concept of immunological surveillance and tumor development
Date
Week 14
Session Topics
Free day (traded for Oct 11)
Readings & Assignments
Nov 22 -24 Thanksgiving
Experience the impact of over satiation and relaxation on comprehension skills
Date
Session Topics
Week 15
Readings & Assignments
Oral Presentations and Reveiw
Nov 29- Dec
1
Application of immunology principles to specific topics selected by students
Date
Week 16
Session Topics
EXAM 4 Cumulative Final
Adopted from Cliff Renk by N Demers
Page 4
Readings & Assignments
Ch 1-12 and presentations
Fall, 2005