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Collaborative Prospective Studies of Cardiovascular Disease
Collaborative Prospective Studies of Cardiovascular Disease

... • 1978 Psychosocial factors found to affect heart disease • 1988 High levels of HDL cholesterol found to reduce risk of death • 1994 Enlarged left ventricle (one of two lower chambers of the heart) shown to increase the risk of stroke • 1996 Progression from hypertension to heart failure described ...
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... A child’s normal heart rate may be as high as 100, that of a infant may be as high as 120, and that of a near term fetus as high of a 140 beats per minute.  These higher rates are not related to age, but to rather to size; the smaller the individual the faster the rate. ...
Mediterranean Diet, Traditional Risk Factors, and the
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... heart disease (CHD) reported impressive reduction of the recurrence rate by a range of 30% to 70%.1–3 These were in contrast with previous dietary trials, which were aimed at reducing blood cholesterol by a low-cholesterol, lowsaturated-fat, high-polyunsaturated-fat diet and failed to significantly ...
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... assumptions required to make such comparisons will depend on the degree of exchangeability of evidence which can be assumed across the existing trial populations and subgroups. One approach will be to consider the post-MI subgroups of controlled trials of aldosterone antagonists in more detail. This ...
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CHAPTER 4: The cardiovascular system

... • Producing an increase in stroke volume (SV). • And decrease in resting heart rate (HRrest). • A reduced resting heart rate allows for an increase in diastolic filling time. • The net effect is that the heart does not have to pump as frequently for the same given resting oxygen consumption. 5) ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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