BMC Developmental Biology
... vertebrae. Accordingly, transgenic animals exhibited missing or reduced intervertebral discs, rostral and caudal articular processes as well as costal heads of ribs. In addition, the midline of the vertebral column did not develop normally. Transgenic mice had open neural arches and split vertebral ...
... vertebrae. Accordingly, transgenic animals exhibited missing or reduced intervertebral discs, rostral and caudal articular processes as well as costal heads of ribs. In addition, the midline of the vertebral column did not develop normally. Transgenic mice had open neural arches and split vertebral ...
alpha-amylase from bacillus licheniformis
... manufactured by pure culture fermentation of the nonpathogenic and nontoxigenic Bacillus licheniformis production strain. The enzyme is subsequently purified, concentrated, and formulated with appropriate substances. The formulated α-amylase is referred to below as the α-amylase preparation. The α-a ...
... manufactured by pure culture fermentation of the nonpathogenic and nontoxigenic Bacillus licheniformis production strain. The enzyme is subsequently purified, concentrated, and formulated with appropriate substances. The formulated α-amylase is referred to below as the α-amylase preparation. The α-a ...
Interactions Between Genes Controlling Pathogenicity in the Flax
... indicating that an AMi/aM, gene pair does occur in the pathogen as predicted by the model: the genotype of the parent strain presumably is iM iMAMiaM,. In this study the observed segregations for pathogenicity on Williston Brown in all three families (Table 1) were consistent with strains CH 5 and I ...
... indicating that an AMi/aM, gene pair does occur in the pathogen as predicted by the model: the genotype of the parent strain presumably is iM iMAMiaM,. In this study the observed segregations for pathogenicity on Williston Brown in all three families (Table 1) were consistent with strains CH 5 and I ...
The bovine papillomavirus type 4 long control region contains an
... mucosal epitheliotropic viruses HPV-16 and -18 are the most common viruses associated with cervical carcinoma and one of the mechanisms restricting these viruses to epithelial cell types involves transcriptional control. The transforming genes of these viruses, E6 and E7, are controlled by the long ...
... mucosal epitheliotropic viruses HPV-16 and -18 are the most common viruses associated with cervical carcinoma and one of the mechanisms restricting these viruses to epithelial cell types involves transcriptional control. The transforming genes of these viruses, E6 and E7, are controlled by the long ...
G enetics - Lantern Publishing
... the inheritance of autosomal single gene disorders. Over 10,000 human diseases are due to single gene alterations and, although rare, they affect one per cent of the human population. Single gene disorders are also known as monogenic disorders. Genetic disorders are caused by abnormal genes. Alleles ...
... the inheritance of autosomal single gene disorders. Over 10,000 human diseases are due to single gene alterations and, although rare, they affect one per cent of the human population. Single gene disorders are also known as monogenic disorders. Genetic disorders are caused by abnormal genes. Alleles ...
PDF
... dog, where PRDM9 is inactive, recombination events are clustered in un-methylated CpG islands [16–18]. In yeast and Arabidopsis recombination hotspots are observed in nucleosomedepleted open chromatin and gene promoters [8,9]. The few invertebrate genomes analysed so far tend to lack extreme recombi ...
... dog, where PRDM9 is inactive, recombination events are clustered in un-methylated CpG islands [16–18]. In yeast and Arabidopsis recombination hotspots are observed in nucleosomedepleted open chromatin and gene promoters [8,9]. The few invertebrate genomes analysed so far tend to lack extreme recombi ...
Epigenetics for behavioral ecologists
... Downloaded from http://beheco.oxfordjournals.org/ at University Library on February 18, 2013 ...
... Downloaded from http://beheco.oxfordjournals.org/ at University Library on February 18, 2013 ...
Sequence requirements for function of the
... machinery for initiation; however, some mechanism must exist to uniquely mark the chorion gene loci origins for activation during amplification, when overall genomic replication has ceased. Large cloned fragments of the chorion gene loci can be re-introduced into the Drosophila genome via P elementm ...
... machinery for initiation; however, some mechanism must exist to uniquely mark the chorion gene loci origins for activation during amplification, when overall genomic replication has ceased. Large cloned fragments of the chorion gene loci can be re-introduced into the Drosophila genome via P elementm ...
Transcriptome analysis of Drosophila CNS midline cells reveals
... revealed that midline cells express 9 neuropeptide precursor genes, 13 neuropeptide receptor genes, and 31 small-molecule neurotransmitter receptor genes. In situ hybridization and high-resolution confocal analyses were carried-out to determine the midline cell identity for these neuropeptides and t ...
... revealed that midline cells express 9 neuropeptide precursor genes, 13 neuropeptide receptor genes, and 31 small-molecule neurotransmitter receptor genes. In situ hybridization and high-resolution confocal analyses were carried-out to determine the midline cell identity for these neuropeptides and t ...
What is Leptin? - jamesjmessina.com
... It was quickly apparent that leptin is generally ineffective as signal for excessive body fat, since obese people generally have higher, not lower, levels of leptin, but yet remain obese Probably more important role of leptin is to signal to body that body fat has fallen to dangerously low levels (f ...
... It was quickly apparent that leptin is generally ineffective as signal for excessive body fat, since obese people generally have higher, not lower, levels of leptin, but yet remain obese Probably more important role of leptin is to signal to body that body fat has fallen to dangerously low levels (f ...
PPT
... but rare in population; may not be reflective of common disease. Also, hard to collect family data. ...
... but rare in population; may not be reflective of common disease. Also, hard to collect family data. ...
Epidermolysis Bullosa Letalis - Center for Arab Genomic Studies
... of epidermolysis bullosa has been delineated. Specific mutations have been demonstrated in 10 different genes expressed within the dermoepidermal adhesion zone, with at least six different genes being involved in the pathogenesis of junctional epidermolysis bullosa. Herlitz junctional epidermolysis ...
... of epidermolysis bullosa has been delineated. Specific mutations have been demonstrated in 10 different genes expressed within the dermoepidermal adhesion zone, with at least six different genes being involved in the pathogenesis of junctional epidermolysis bullosa. Herlitz junctional epidermolysis ...
Expression of p53 Target Genes in the Early Phase of Long
... Accumulating evidence suggests that p53 should be viewed ...
... Accumulating evidence suggests that p53 should be viewed ...
MTHFR C677T and A1298C: Explained In Plain
... Heterozygous A1298C is thought to be of minor consequence (if any), while heterozygous C677T may affect folate metabolism by up to 35% (3, 11). MTHFR mutations that have the greatest influence on health are: Homozygous A1298C (C1298C) and homozygous C677T (T677T) Compound heterozgous A1298C + C677T ...
... Heterozygous A1298C is thought to be of minor consequence (if any), while heterozygous C677T may affect folate metabolism by up to 35% (3, 11). MTHFR mutations that have the greatest influence on health are: Homozygous A1298C (C1298C) and homozygous C677T (T677T) Compound heterozgous A1298C + C677T ...
Anterior-posterior patterning within the
... germline (Wood, 1988). Anterior cells have short microvilli (Sulston and Horvitz, 1977), are associated with an expanded gut lumen and do not express the pho-1 acid phosphatase activity on their lumenal surface (Beh et al., 1991). We have previously described an example of anteriorposterior patterni ...
... germline (Wood, 1988). Anterior cells have short microvilli (Sulston and Horvitz, 1977), are associated with an expanded gut lumen and do not express the pho-1 acid phosphatase activity on their lumenal surface (Beh et al., 1991). We have previously described an example of anteriorposterior patterni ...
Gene conversion and purifying selection shape nucleotide variation
... When a sample from a male showed two nucleotide peaks at one or more sites (“heterozygous” sites) in the L or M opsin gene, the individual should have two or more loci of the gene with different sequences. In this case, we conservatively inferred two loci for this gene. When a female showed heterozy ...
... When a sample from a male showed two nucleotide peaks at one or more sites (“heterozygous” sites) in the L or M opsin gene, the individual should have two or more loci of the gene with different sequences. In this case, we conservatively inferred two loci for this gene. When a female showed heterozy ...
Polygenic Disorders
... • Examples of thrifty genes include those resulting in high levels of insulin and leptin – Insulin - mediates the uptake of glucose by cells – Leptin - hormone released by fat cells that regulates ...
... • Examples of thrifty genes include those resulting in high levels of insulin and leptin – Insulin - mediates the uptake of glucose by cells – Leptin - hormone released by fat cells that regulates ...
Global Transcriptional Profiling Reveals Distinct Functions of Thymic
... Functions of Thymic Stromal Subsets We identified differentially expressed genes (DEGs) in each stromal subset as those genes uniquely up- or downregulated by >2fold relative to all other stromal subsets of the same age, with an adjusted p value < 0.01 (Table S1). As expected from PCA analysis, mTEC ...
... Functions of Thymic Stromal Subsets We identified differentially expressed genes (DEGs) in each stromal subset as those genes uniquely up- or downregulated by >2fold relative to all other stromal subsets of the same age, with an adjusted p value < 0.01 (Table S1). As expected from PCA analysis, mTEC ...
STATISTICAL GENETICS `98 Transmission Disequilibrium, Family
... Application of the TDT in Linkage Studies The TDT method has been widely applied to test for linkage between candidate-gene regions and a variety of complex disorders. Some issues regarding the interpretation of positive findings by the TDT method warrant discussion. If only affected subjects are sa ...
... Application of the TDT in Linkage Studies The TDT method has been widely applied to test for linkage between candidate-gene regions and a variety of complex disorders. Some issues regarding the interpretation of positive findings by the TDT method warrant discussion. If only affected subjects are sa ...
Chapter 14: MENDEL AND THE GENE IDEA
... The dominant allele is the one that is expressed (it exerts its phenotypic effect) in a heterozygote. It is identified with a uppercase (capital) letter, usually the first letter of the trait. Recessive Allele whose phenotypic effect is not observed in a heterozygote; its expression is masked by ...
... The dominant allele is the one that is expressed (it exerts its phenotypic effect) in a heterozygote. It is identified with a uppercase (capital) letter, usually the first letter of the trait. Recessive Allele whose phenotypic effect is not observed in a heterozygote; its expression is masked by ...
Charcot-Marie
... on the outer side of the calves are particularly affected. Other names include DejerineSottas disease and hereditary hypertrophic neuropathy. The term CMT is now the favoured term and is the term most commonly used in the literature. CMT does not describe a single disorder, but a group of conditions ...
... on the outer side of the calves are particularly affected. Other names include DejerineSottas disease and hereditary hypertrophic neuropathy. The term CMT is now the favoured term and is the term most commonly used in the literature. CMT does not describe a single disorder, but a group of conditions ...
Genomics Reveal Ancient Forms of Stanniocalcin in Amphioxus and
... 2006), and the non-teleostean gar and bowfin (Amemiya and Youson 2004). All these hormones share consistent structural features, including a conserved N-glycosylation site and 10 invariant cysteine residues that form intrachain disulfide bonds. Also, an 11th conserved cysteine residue that is critic ...
... 2006), and the non-teleostean gar and bowfin (Amemiya and Youson 2004). All these hormones share consistent structural features, including a conserved N-glycosylation site and 10 invariant cysteine residues that form intrachain disulfide bonds. Also, an 11th conserved cysteine residue that is critic ...
Two Waves of Nuclear Factor κB Recruitment to Target Promoters
... 36–38). As the N-terminal tail domains of histones protrude out of the nucleosome, they provide an extended surface for interactions with other nucleosomes, thus modulating chromatin folding. At the same time, histone tails may act as receptors for enzymes implicated in signal transduction to chroma ...
... 36–38). As the N-terminal tail domains of histones protrude out of the nucleosome, they provide an extended surface for interactions with other nucleosomes, thus modulating chromatin folding. At the same time, histone tails may act as receptors for enzymes implicated in signal transduction to chroma ...
Eds., N. Hamamura, S. Suzuki, S. Mendo, C. M. Barroso,... © by TERRAPUB, 2010.
... An increased expression level of this gene was observed as the TBT concentration in the culture media increased. No apparent differences were detected on the expression levels of sugE clone (sugE clone), suggesting that in this clone this gene is constitutively expressed. As expected, in clone pUC19 ...
... An increased expression level of this gene was observed as the TBT concentration in the culture media increased. No apparent differences were detected on the expression levels of sugE clone (sugE clone), suggesting that in this clone this gene is constitutively expressed. As expected, in clone pUC19 ...
Deletions of NF1 gene and exons detected by multiplex ligation
... neurofibromin, is a ubiquitously expressed protein, with structural and functional similarities to the mammalian GTPase-activating protein (GAP)-related protein family, a group of evolutionarily conserved proteins.7–9 The most highly conserved region of the protein is the NF1 GAP-related domain (GRD ...
... neurofibromin, is a ubiquitously expressed protein, with structural and functional similarities to the mammalian GTPase-activating protein (GAP)-related protein family, a group of evolutionarily conserved proteins.7–9 The most highly conserved region of the protein is the NF1 GAP-related domain (GRD ...