Unraveling the Genetic Mysteries of the Corneal Dystrophies
... Three types have been described based upon the presence of antigenic keratan sulfate Vision more severely affected than in other stromal dystrophies Characterized by stromal haze, and milky white opacities (glucosamineglycans; descemet’s membrane and the endothelium can be involved –with gutatta) • ...
... Three types have been described based upon the presence of antigenic keratan sulfate Vision more severely affected than in other stromal dystrophies Characterized by stromal haze, and milky white opacities (glucosamineglycans; descemet’s membrane and the endothelium can be involved –with gutatta) • ...
Disruption and aberrant expression of HMGA2 as a
... human mesenchymal tumors, resulting in fusion to diverse partner genes. In lipomas, HMGA2 has been shown to fuse to LPP at 3q27–q28, a gene encoding an LIM domain-containing protein;8,15 to LHFP at 13q12, the function of which is still unknown;16 to the G-protein-coupled receptor RDC1 at 2q35– 3717 ...
... human mesenchymal tumors, resulting in fusion to diverse partner genes. In lipomas, HMGA2 has been shown to fuse to LPP at 3q27–q28, a gene encoding an LIM domain-containing protein;8,15 to LHFP at 13q12, the function of which is still unknown;16 to the G-protein-coupled receptor RDC1 at 2q35– 3717 ...
Type I Factor XI11 Deficiency Is Caused By a
... Nucleotide sequence analysis. The amplified DNA samples were digested with restriction enzymes to generate the proper ends for ligation into sequencing vectors. The digested samples were applied to a 0.8% agarose gel, electroeluted, and then subcloned into M13mp18 or M13mp19 (GIBCO-BRL, Gathersburg, ...
... Nucleotide sequence analysis. The amplified DNA samples were digested with restriction enzymes to generate the proper ends for ligation into sequencing vectors. The digested samples were applied to a 0.8% agarose gel, electroeluted, and then subcloned into M13mp18 or M13mp19 (GIBCO-BRL, Gathersburg, ...
Dynamic Changes in Aromatic Hydrocarbon Associated Catabolic
... generated were used to prepare standards for use in qPCR assays with primer BZAQ4F and PFR1 (5`TCCTGMCCGCCSATGTCSAG`3) [17]. Primer PFR1 was designed through multiple sequence alignments (ClustalW-EBI) of bcr α subunits present in T. aromatica, R. palustris, A. evansii and M. magneticum and used to ...
... generated were used to prepare standards for use in qPCR assays with primer BZAQ4F and PFR1 (5`TCCTGMCCGCCSATGTCSAG`3) [17]. Primer PFR1 was designed through multiple sequence alignments (ClustalW-EBI) of bcr α subunits present in T. aromatica, R. palustris, A. evansii and M. magneticum and used to ...
of Lactobacillus pentosus
... Davis et al., 1984, Davis and Henderson, 1987). This xylE gene was not found within the cluster of xyl genes but is present on a separate locus on theE. coli chromosome. The xylR gene codes for a regulatory protein involved in the activation of expression of the xylose genes in the presence of D-xyl ...
... Davis et al., 1984, Davis and Henderson, 1987). This xylE gene was not found within the cluster of xyl genes but is present on a separate locus on theE. coli chromosome. The xylR gene codes for a regulatory protein involved in the activation of expression of the xylose genes in the presence of D-xyl ...
The development of apical embryonic pattern in Arabidopsis
... expression was seen in any sections of this embryo. Note that the morphology of this embryo is very similar to the wild-type embryo in Fig. 5C. The substrate used was Western Blue in all panels except E and G where it was Fast Red. pr, embryonic peripheral region; cr, embryonic central region; arrow ...
... expression was seen in any sections of this embryo. Note that the morphology of this embryo is very similar to the wild-type embryo in Fig. 5C. The substrate used was Western Blue in all panels except E and G where it was Fast Red. pr, embryonic peripheral region; cr, embryonic central region; arrow ...
Transvection and pairing of a Drosophila Hox long noncoding RNA
... mutations break within a region in the ftz-Antp interval where intergenic transcription has been previously observed (Calhoun and Levine 2003). One additional GOF mutation maps distal to this region in the first intron of Antp. Though transcripts from the ftz-Antp interval have been structurally det ...
... mutations break within a region in the ftz-Antp interval where intergenic transcription has been previously observed (Calhoun and Levine 2003). One additional GOF mutation maps distal to this region in the first intron of Antp. Though transcripts from the ftz-Antp interval have been structurally det ...
T-box-mediated control of the anabolic proline biosynthetic genes of
... Bacillus subtilis possesses interlinked routes for the synthesis of proline. The ProJ–ProA–ProH route is responsible for the production of proline as an osmoprotectant, and the ProB–ProA–ProI route provides proline for protein synthesis. We show here that the transcription of the anabolic proBA and ...
... Bacillus subtilis possesses interlinked routes for the synthesis of proline. The ProJ–ProA–ProH route is responsible for the production of proline as an osmoprotectant, and the ProB–ProA–ProI route provides proline for protein synthesis. We show here that the transcription of the anabolic proBA and ...
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... (ATHB2), HOMEOBOX ARABIDOPSIS THALIANA 1 (HAT1), HAT2, HAT3 and ATHB4 are regulated by changes in the red/far red light ratio that induce shade avoidance in most of the angiosperms. Here, we show that progressive loss of HAT3, ATHB4 and ATHB2 activity causes developmental defects from embryogenesis ...
... (ATHB2), HOMEOBOX ARABIDOPSIS THALIANA 1 (HAT1), HAT2, HAT3 and ATHB4 are regulated by changes in the red/far red light ratio that induce shade avoidance in most of the angiosperms. Here, we show that progressive loss of HAT3, ATHB4 and ATHB2 activity causes developmental defects from embryogenesis ...
Heavy Chain Diversity Region Segments of the Channel Catfish
... flanking region of the respective JH segment continued further upstream (data not shown), and in each clone, the JH coding and 3⬘-flanking regions were absent. This indicated that each clone represents an extrachromosomal product of a recombination event between a germline JH gene segment and a puta ...
... flanking region of the respective JH segment continued further upstream (data not shown), and in each clone, the JH coding and 3⬘-flanking regions were absent. This indicated that each clone represents an extrachromosomal product of a recombination event between a germline JH gene segment and a puta ...
ACTIN-RELATED PROTEIN6 Regulates Female Meiosis By
... events in megasporogenesis using a pSPL:GUS line (harboring the SPOROCYTELESS promoter fused to the b-glucuronidase reporter gene; Ito et al., 2004) as a marker for differentiation of the archesporial cell to a megasporocyte (Yang et al., 1999) at the distal end of each ovule primordium (Schneitz et ...
... events in megasporogenesis using a pSPL:GUS line (harboring the SPOROCYTELESS promoter fused to the b-glucuronidase reporter gene; Ito et al., 2004) as a marker for differentiation of the archesporial cell to a megasporocyte (Yang et al., 1999) at the distal end of each ovule primordium (Schneitz et ...
Antibiotic susceptibility pattern among Staphylococcus spp. with
... may be in part explained by the prescription of penicillin and oxacillin for a long time in contrast to vancomycin in other countries. MRSA infection has recently become a serious problem in anti-microbial chemotherapy. This is why during the past four decades, MRSA has spread throughout the world a ...
... may be in part explained by the prescription of penicillin and oxacillin for a long time in contrast to vancomycin in other countries. MRSA infection has recently become a serious problem in anti-microbial chemotherapy. This is why during the past four decades, MRSA has spread throughout the world a ...
The full-length HIV-1 molecular clone pLAI 61 was used to produce
... gift of Dr. Jean-Marc Jacque, University of Massachusetts Medical School, USA), and pH1sh-nef have been described previously 7,8. ...
... gift of Dr. Jean-Marc Jacque, University of Massachusetts Medical School, USA), and pH1sh-nef have been described previously 7,8. ...
Alu repeat analysis in the complete human genome: trends and
... Alu repeats have a copy number of over one million in the human genome, which is much higher than previous estimates (Weiner, 2000; Deininger and Batzer, 1999). The frequency of their occurrence in the sequenced region, on average, comes out to be about one repeat element per 2.5 kb, which is also h ...
... Alu repeats have a copy number of over one million in the human genome, which is much higher than previous estimates (Weiner, 2000; Deininger and Batzer, 1999). The frequency of their occurrence in the sequenced region, on average, comes out to be about one repeat element per 2.5 kb, which is also h ...
Opsin genes, cone photopigments, color vision, and color blindness
... the light absorbing properties of the L- M-, and S-cones, measured at the cornea, as a function of wavelength (see Chapter 2, Table 2.1, for values). The heights of the curves have been adjusted according to the assumption that the relative cone sensitivities depend on the relative numbers of the di ...
... the light absorbing properties of the L- M-, and S-cones, measured at the cornea, as a function of wavelength (see Chapter 2, Table 2.1, for values). The heights of the curves have been adjusted according to the assumption that the relative cone sensitivities depend on the relative numbers of the di ...
Molecular Biology Reports
... of deduced amino acid sequence showed 98, 87, and 86 % sequence identity with LCY-b of Ipomoea sp. Kenyan, S. tuberosum chloroplastic-like LCY-b, and S. lycopersicum chloroplastic-like LCY-b, respectively (Fig. 2a). IbLCY-b has conserved motifs related to dinucleotide-binding motif in a specific pro ...
... of deduced amino acid sequence showed 98, 87, and 86 % sequence identity with LCY-b of Ipomoea sp. Kenyan, S. tuberosum chloroplastic-like LCY-b, and S. lycopersicum chloroplastic-like LCY-b, respectively (Fig. 2a). IbLCY-b has conserved motifs related to dinucleotide-binding motif in a specific pro ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... al., 2008). Low levels of reactive oxygen species (ROS) are crucial in maintaining normal cellular physiologic functions, such as proliferation, apoptosis, and cell cycle arrest; whereas increased levels of ROS induce oxidative stress and cause an imbalanced hemostatic microenvironment (Aggarwal and ...
... al., 2008). Low levels of reactive oxygen species (ROS) are crucial in maintaining normal cellular physiologic functions, such as proliferation, apoptosis, and cell cycle arrest; whereas increased levels of ROS induce oxidative stress and cause an imbalanced hemostatic microenvironment (Aggarwal and ...
by Vanessa Di Gioacchino A thesis submitted to the Department of Biology
... poorly understood. Understanding the genetic and biological mechanisms underlying these disorders can lead to significant improvements in diagnosis, treatment, and quality of life for patients suffering from mental disorders. Goα47A is a candidate gene in a putative haloperidol-affected pathway that ...
... poorly understood. Understanding the genetic and biological mechanisms underlying these disorders can lead to significant improvements in diagnosis, treatment, and quality of life for patients suffering from mental disorders. Goα47A is a candidate gene in a putative haloperidol-affected pathway that ...
The Nodal Pathway Acts Upstream of Hedgehog
... 1995). Both nk2.1 genes are therefore induced in proximity to cells expressing components of both the Hh and Nodal signaling pathways. Analysis of nk2.1a and nk2.1b expression at postepiboly stages revealed that nk2.1a is expressed exclusively in the ventral diencephalon (hypothalamus), while nk2.1b ...
... 1995). Both nk2.1 genes are therefore induced in proximity to cells expressing components of both the Hh and Nodal signaling pathways. Analysis of nk2.1a and nk2.1b expression at postepiboly stages revealed that nk2.1a is expressed exclusively in the ventral diencephalon (hypothalamus), while nk2.1b ...
The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle
... mice by replacing the conserved functional domains (HD and SD) regions of the Six1 gene using a homologous recombination approach. These Six1-/- transgenic mice die at birth due to extensive muscle hypoplasia and severe rib malformations [3]. Moreover, Six4 was also shown to play an important role i ...
... mice by replacing the conserved functional domains (HD and SD) regions of the Six1 gene using a homologous recombination approach. These Six1-/- transgenic mice die at birth due to extensive muscle hypoplasia and severe rib malformations [3]. Moreover, Six4 was also shown to play an important role i ...
(F193L) in the KCNQ1 gene associated with long
... Priori et al. [10] reported that LQTS may appear with a very low penetrance in some families, and the family members considered to be normal may be silent gene carriers and are unexpectedly at risk of developing torsades de pointes when they are exposed to repolarization-prolonging drugs. Recently, ...
... Priori et al. [10] reported that LQTS may appear with a very low penetrance in some families, and the family members considered to be normal may be silent gene carriers and are unexpectedly at risk of developing torsades de pointes when they are exposed to repolarization-prolonging drugs. Recently, ...
Muscle pattern diversification in Drosophila: the story of
... positions. This specific distribution of myoblasts could involve an active migration of these cells to the presumptive notal region as the disc grows and expands during larval life, or there could be specific signals in the prospective wingblade region that prevents these cells from distributing the ...
... positions. This specific distribution of myoblasts could involve an active migration of these cells to the presumptive notal region as the disc grows and expands during larval life, or there could be specific signals in the prospective wingblade region that prevents these cells from distributing the ...
Problem Sets - MIT Biology
... Strain Three (B–/B–) is homozygous for a recessive mutation in gene B. Group Four are flies that result from mating Strain One to Strain Two. Group Five are flies that result from mating Strain One to Strain Three. Group Six are flies that result from mating Strain Two to Strain Three. Group Seven a ...
... Strain Three (B–/B–) is homozygous for a recessive mutation in gene B. Group Four are flies that result from mating Strain One to Strain Two. Group Five are flies that result from mating Strain One to Strain Three. Group Six are flies that result from mating Strain Two to Strain Three. Group Seven a ...
Fkh5-deficient mice show dysgenesis in the caudal midbrain and
... Early embryonic Fkh5 expression is restricted to the mammillary body region of the caudal hypothalamus, midbrain, hindbrain and spinal cord. Postnatally, signals persist in specific nuclei of the mammillary body and in the midbrain. We generated Fkh5 deficient mice by homologous recombination to ass ...
... Early embryonic Fkh5 expression is restricted to the mammillary body region of the caudal hypothalamus, midbrain, hindbrain and spinal cord. Postnatally, signals persist in specific nuclei of the mammillary body and in the midbrain. We generated Fkh5 deficient mice by homologous recombination to ass ...
4 Mapping Eukaryotic Chromosomes by
... a. In Figure 4-21, let GC = A and AT = a, then draw the fungal octad that would result from the final structure (5). b. (Challenging) Insert some closely linked flanking markers into the diagram, say P/p to the left and Q/q to the right (assume either cis or trans arrangements). Assume neither of th ...
... a. In Figure 4-21, let GC = A and AT = a, then draw the fungal octad that would result from the final structure (5). b. (Challenging) Insert some closely linked flanking markers into the diagram, say P/p to the left and Q/q to the right (assume either cis or trans arrangements). Assume neither of th ...