Interactive Visualization of Gene Regulatory Networks with
... for visualization of gene regulatory networks. Gene regulatory networks can be represented by graphs, in which nodes represent genes, and edges represent interactions between a gene product (a regulator protein) and its target genes. The nodes have several attributes, such as position on the chromos ...
... for visualization of gene regulatory networks. Gene regulatory networks can be represented by graphs, in which nodes represent genes, and edges represent interactions between a gene product (a regulator protein) and its target genes. The nodes have several attributes, such as position on the chromos ...
c-Myc co-ordinates mRNA cap methylation and ribosomal RNA
... Figure 1. Expression of the mRNA cap methyltransferase complex, RNMT–RAM, is required for 45S rRNA production. HeLa cells were transfected into two independent RAM siRNAs, an RNMT siRNA and a non-targeting control siRNA, for 48 h. (A) Expression of RNMT, RAM and GAPDH was analysed by western blot. ( ...
... Figure 1. Expression of the mRNA cap methyltransferase complex, RNMT–RAM, is required for 45S rRNA production. HeLa cells were transfected into two independent RAM siRNAs, an RNMT siRNA and a non-targeting control siRNA, for 48 h. (A) Expression of RNMT, RAM and GAPDH was analysed by western blot. ( ...
Interplay between copy number, dosage compensation and
... copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene copy number are important drivers of some human diseases and understanding these effects ma ...
... copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene copy number are important drivers of some human diseases and understanding these effects ma ...
Molecular bases of Down syndrome: differential gene
... abnormal processing of amyloid beta precursor APP (Lott et al., 2006). As to the total antioxidant capacity, it was shown to be decreased in one study and preserved in another (Carratelli et al., 2001; Zitnanova et al., 2006). In particular, impairment of the glutathione redox state has been observ ...
... abnormal processing of amyloid beta precursor APP (Lott et al., 2006). As to the total antioxidant capacity, it was shown to be decreased in one study and preserved in another (Carratelli et al., 2001; Zitnanova et al., 2006). In particular, impairment of the glutathione redox state has been observ ...
Association of the T-cell regulatory gene CTLA4 with susceptibility to
... with lower messenger RNA levels of the soluble alternative splice form of CTLA4. In the mouse model of type 1 diabetes, susceptibility was also associated with variation in CTLA-4 gene splicing with reduced production of a splice form encoding a molecule lacking the CD80/CD86 ligand-binding domain. ...
... with lower messenger RNA levels of the soluble alternative splice form of CTLA4. In the mouse model of type 1 diabetes, susceptibility was also associated with variation in CTLA-4 gene splicing with reduced production of a splice form encoding a molecule lacking the CD80/CD86 ligand-binding domain. ...
Problems of Birds Sex Determination
... unexpressed 270-bp region in intron 3 of emu DMRT1 gene showed 90% homology with a sequence in the corresponding intron of human DMRT1 [18]. This high conservatism suggests important role in controlling the expression of DMRT1, for example, control of methylation in females. Two copies of the gene a ...
... unexpressed 270-bp region in intron 3 of emu DMRT1 gene showed 90% homology with a sequence in the corresponding intron of human DMRT1 [18]. This high conservatism suggests important role in controlling the expression of DMRT1, for example, control of methylation in females. Two copies of the gene a ...
Validated preCRMs
... Two somatic cell models of late erythroid maturation were used to find groups of genes whose expression levels increase or decrease during this process. Murine erythroleukemia (MEL) cells have properties of proerythroblasts, and are induced to mature into erythroblasts upon treatment with N,N’-hexam ...
... Two somatic cell models of late erythroid maturation were used to find groups of genes whose expression levels increase or decrease during this process. Murine erythroleukemia (MEL) cells have properties of proerythroblasts, and are induced to mature into erythroblasts upon treatment with N,N’-hexam ...
the human y chromosome, in the light of evolution
... loci are not expressed in humans, as in many other taxa with XY systems, whereas their X counterparts remain active. This observation belies the pervasive decay that is associated with overly robust linkage. Nevertheless, a handful of non-recombining homologue pairs remain active on both chromosomes ...
... loci are not expressed in humans, as in many other taxa with XY systems, whereas their X counterparts remain active. This observation belies the pervasive decay that is associated with overly robust linkage. Nevertheless, a handful of non-recombining homologue pairs remain active on both chromosomes ...
Relative Gene Expression Workflow
... normalization are advocated by some members of the scientific community, including the use of multiple normalizers as an effort to minimize the error of any single choice. Others argue that normalization based on starting template mass – which lies at the heart of the approach described here – may n ...
... normalization are advocated by some members of the scientific community, including the use of multiple normalizers as an effort to minimize the error of any single choice. Others argue that normalization based on starting template mass – which lies at the heart of the approach described here – may n ...
Gene expression patterns in human placenta
... atrophied remnants of villi and associated fetal blood vessels. The chorion is interdigitated with maternal decidua and its associated blood vessels. The umbilical cord consists of an amniotic epithelium, two arteries, and one vein embedded in a matrix called Wharton’s Jelly. The villus parenchyma m ...
... atrophied remnants of villi and associated fetal blood vessels. The chorion is interdigitated with maternal decidua and its associated blood vessels. The umbilical cord consists of an amniotic epithelium, two arteries, and one vein embedded in a matrix called Wharton’s Jelly. The villus parenchyma m ...
Bio II Ch 19 Eukaryotic Genomes
... 2. The control of gene expression can occur at any step in the pathway from gene to functional protein: an overview 3. Chromatin modifications affect the availability of genes for transcription 4. Transcription initiation is controlled by proteins that interact with DNA and each other 5. Post-transc ...
... 2. The control of gene expression can occur at any step in the pathway from gene to functional protein: an overview 3. Chromatin modifications affect the availability of genes for transcription 4. Transcription initiation is controlled by proteins that interact with DNA and each other 5. Post-transc ...
Slide 1
... • For CRM data, the best combination of five clustered transcription factor binding sites – in all human-mouse conserved non-coding sequences (up to 10 kb upstream of transcription start site) of the training genes – is determined using a genetic algorithm. ...
... • For CRM data, the best combination of five clustered transcription factor binding sites – in all human-mouse conserved non-coding sequences (up to 10 kb upstream of transcription start site) of the training genes – is determined using a genetic algorithm. ...
Gene regulation_1130(final)
... • Insulin affects transcription, mRNA stability, and translation (from gene to protein) • Focusing on insulin-regulated gene transcription – Positive and negative effects on the transcription of specific genes even within the same cell. – Insulin-regulated genes coding proteins involved in a varie ...
... • Insulin affects transcription, mRNA stability, and translation (from gene to protein) • Focusing on insulin-regulated gene transcription – Positive and negative effects on the transcription of specific genes even within the same cell. – Insulin-regulated genes coding proteins involved in a varie ...
Leukaemia Section t(11;20)(p15;q11) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Structural diagrams of NUP98, TOP1, and fused chimeras. Fused protein has N-terminal of NUP98, which contains two FG repeats, and the core, link and catalytic domains of TOP1. Gene product of TOP1/NUP98 (150kD) has been demonstrated, but the fused protein of TOP1/NUP98 has not been examined. Iwase S ...
... Structural diagrams of NUP98, TOP1, and fused chimeras. Fused protein has N-terminal of NUP98, which contains two FG repeats, and the core, link and catalytic domains of TOP1. Gene product of TOP1/NUP98 (150kD) has been demonstrated, but the fused protein of TOP1/NUP98 has not been examined. Iwase S ...
2) TF Gene-Disease Association Property Predictions
... human expert), the candidate genes are compared to the disease genes underlying the diseases in each cluster using the annotations from GOA. The score for a candidate gene for a disease cluster is the average, over all GO terms, of the ratio of occurrences of the GO term in the cluster, if it matche ...
... human expert), the candidate genes are compared to the disease genes underlying the diseases in each cluster using the annotations from GOA. The score for a candidate gene for a disease cluster is the average, over all GO terms, of the ratio of occurrences of the GO term in the cluster, if it matche ...
Eukaryotic Genes and Genomes II
... In the last lecture we considered the structure of genes in eukaryotic organisms and went on to figure out a way to identify S. cerevisiae genes that are transcriptionally regulated in response to a change in environment. The ability to regulate gene expression in response to environmental cues is a ...
... In the last lecture we considered the structure of genes in eukaryotic organisms and went on to figure out a way to identify S. cerevisiae genes that are transcriptionally regulated in response to a change in environment. The ability to regulate gene expression in response to environmental cues is a ...
Understanding the Basis for Down Syndrome Phenotypes
... expression on development and function. The bestcharacterized mouse models to date are trisomic for segments of mouse Chromosome 16 (Mmu16) conserved with Hsa21. The Ts65Dn mouse is trisomic for a segment that contains orthologs of about half of Hsa21 genes while Ts1Cje mice are trisomic for about ...
... expression on development and function. The bestcharacterized mouse models to date are trisomic for segments of mouse Chromosome 16 (Mmu16) conserved with Hsa21. The Ts65Dn mouse is trisomic for a segment that contains orthologs of about half of Hsa21 genes while Ts1Cje mice are trisomic for about ...
Other RNA Processing Events
... • This workforce solution was funded by a grant awarded under the President’s Community-Based Job Training Grants as implemented by the U.S. Department of Labor’s Employment and Training Administration. The solution was created by the grantee and does not necessarily reflect the official position of ...
... • This workforce solution was funded by a grant awarded under the President’s Community-Based Job Training Grants as implemented by the U.S. Department of Labor’s Employment and Training Administration. The solution was created by the grantee and does not necessarily reflect the official position of ...
Molecular and Cellular Biology, September 2000, p
... general control of chromatin remodeling during cell differentiation. Indeed, through the control of a specific group of genes encoding chromatin-associated proteins (such as H10), these molecules may regulate chromatin structure and function. Transcription factors interacting with the H10 promoter a ...
... general control of chromatin remodeling during cell differentiation. Indeed, through the control of a specific group of genes encoding chromatin-associated proteins (such as H10), these molecules may regulate chromatin structure and function. Transcription factors interacting with the H10 promoter a ...
Mapping the Genetic Architecture of Gene Expression in Human Liver
... associated traits. Because a majority of single nucleotide polymorphisms (SNPs) detected as associated with disease traits from the recent wave of genome-wide association studies (GWASs) do not appear to affect protein sequence, it is likely that these SNPs either regulate gene activity at the trans ...
... associated traits. Because a majority of single nucleotide polymorphisms (SNPs) detected as associated with disease traits from the recent wave of genome-wide association studies (GWASs) do not appear to affect protein sequence, it is likely that these SNPs either regulate gene activity at the trans ...
Cold-induced silencing by long antisense transcripts of an
... RNAs may function in both cis and trans19. In a wider context, our discoveries on FLC may have broad relevance to other organisms where a genome-wide association of non-coding RNA transcript start sites with 39 regions has been observed4. Many studies have found a strong correlation between sense an ...
... RNAs may function in both cis and trans19. In a wider context, our discoveries on FLC may have broad relevance to other organisms where a genome-wide association of non-coding RNA transcript start sites with 39 regions has been observed4. Many studies have found a strong correlation between sense an ...
rna metabolism: how different bacteria reached the same
... These shared properties make it likely that the way mRNA is processed and degraded are more similar between these two evolutionarily diverged classes of organisms – gram positive and negative – than previously thought. The effects of RNase Y As mentioned before, mRNA is only one of the types of RNA ...
... These shared properties make it likely that the way mRNA is processed and degraded are more similar between these two evolutionarily diverged classes of organisms – gram positive and negative – than previously thought. The effects of RNase Y As mentioned before, mRNA is only one of the types of RNA ...
