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Why have organelles retained genomes?
Why have organelles retained genomes?

... What kind of darwinian selection? Previous conjecture on the evolutionary rationale behind organelle genomes has produced a number of possible explanations. One of the most widely held notions is that all genes have the potential to be expressed in the nucleus but some of the resulting proteins are ...
Li, H., and Baker, B. S.
Li, H., and Baker, B. S.

... necessary for male sexual behavior (Hall, 1994; Ito et al., 1996; Ryner et al., 1996; Taylor et al., 1994) and the development of a male-specific abdominal muscle, the Muscle of Lawrence (MOL) (Gailey et al., 1991; Ito et al., 1996; Lawrence and Johnston, 1986; Ryner et al., 1996). The female-specif ...
The silence of genes
The silence of genes

... similar species.” According to this theory, it is in the interests of both parents to maintain efficient nutrient transfer from mother to child while the two are either physically attached through the placenta or endosperm, or closely coupled, as when suckling. Indeed, there is evidence that ...
Gene Section IGH (Immunoglobulin Heavy) Atlas of Genetics and Cytogenetics
Gene Section IGH (Immunoglobulin Heavy) Atlas of Genetics and Cytogenetics

... The most 5' IGHV genes occupy a position very close to the chromosome 14q telomere whereas the IGHC genes are in a more centromeric position. The potentiel genomic IGH repertoire is more limited since it comprises 38-46 functional IGHV genes belonging to 6 or 7 subgroups depending from the haplotype ...
Results - Hal Cirad
Results - Hal Cirad

... Coffee belongs to the large botanical family Rubiaceae, which includes tropical trees and shrubs growing in the lower storey of forests. Coffea is by far the most important member of the family economically, and C. arabica (Arabica coffee) accounts for over 70% of world coffee production. C. arabica ...
Leukaemia Section t(10;11)(q22;q23) KMT2A/TET1 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(10;11)(q22;q23) KMT2A/TET1 Atlas of Genetics and Cytogenetics in Oncology and Haematology

... of TET1 and promote its expression directly in both human and mouse hematopoietic stem/progenitor cells, cumulating in a global increase of 5hmC. Briefly, MLL-fusion proteins bind directly to the Tet1 locus. Consequently this promote its expression and the increased expression of Tet1 ...
10709_2015_9875_MOESM4_ESM
10709_2015_9875_MOESM4_ESM

... biology, not an artifact. Therefore, while our lists of "slow growth" genes are robust (due to stringent selection criteria); they are probably not completely comprehensive.” In more detail, the authors applied a conservative procedure to restrict the analysis to highly confident HI genes. However, ...
Continuous Representations of Time Series Gene Expression Data
Continuous Representations of Time Series Gene Expression Data

... methods to gene expression data. Unlike the above papers, we focus on the gene specific aspects rather than the common class profile. In addition, we present a method that is able to deal with cases in which class membership is not given. Another difference between this work and [11] is that we do n ...
3283 Proper chromatin condensation and sister chromatid
3283 Proper chromatin condensation and sister chromatid

... 3284 N. U. Siddiqui and others In both plants and animals, alterations in chromatin structure and dynamics are implicated as factors controlling both cell cycle progression and aspects of development (reviewed by Muller and Leutz, 2001; Reyes et al., 2002; Berger and Gaudin, 2003). Whereas in many ...
Supporting information for “Dynamics of cell
Supporting information for “Dynamics of cell

... GUS staining assays showed ectopic expression of both ASL [32] promoter–reporter genes in the nonvascular tissues of plants overexpressing VND7 and VND6. Overexpression of ASL19 or ASL20 induced transdifferentiation of cells from nonvascular tissues into TElike cells, similar to those formed upon VN ...
PPT
PPT

... CMSC 838T – Presentation ...
ppt - Chair of Computational Biology
ppt - Chair of Computational Biology

... Availability of DNA microarray data  study transcriptional response of a complete genome to different experimental conditions. An essential task in studying the global structure of transcriptional networks is the gene classification. Commonly used clustering algorithms classify genes successfully w ...
Article Comparative Genomics as a Time Machine: How Relative
Article Comparative Genomics as a Time Machine: How Relative

... copy. As the number of duplicates fell, their average number of targets increased, while at the same time an increasing percentage of the genes with more regulators were also returned to single copy. The same visual pattern is seen for a gene’s status as the target of a kinase, although it is not st ...
Supplementary materials
Supplementary materials

... which considered the protein-coding information. In detail we divided each NMD stop-exon in humans into the 5’ part and 3’ part relative to the stop codon. Then we align the 5’ part with the coding region of the mouse orthologous exon at the peptide level using needle [7]. To minimize the sample var ...
FOXP2 in focus: what can genes tell us about speech and language?
FOXP2 in focus: what can genes tell us about speech and language?

... program; if certain conditions hold, then a protein is synthesized. Transcription factors, like that encoded by FOXP2, are proteins that interact with the regulatory regions of genes and modulate their transcription levels, thereby ultimately influencing the relative abundances of other proteins in ...
Microarray experiment guidelines
Microarray experiment guidelines

... Capable of simultaneously measuring the expression levels for thousands of genes, microarrays provide a large quantity of information about an organism/cell/tissue – whether it be mutational studies (monitoring the effects of gene expression by knocking out/in a particular gene), conditional (monito ...
2 - GEP Community Server
2 - GEP Community Server

The role of regulatory variation in complex traits and
The role of regulatory variation in complex traits and

... to 2 Mb in humans7; some studies even require distant eQTLs to be located on different chromosomes from the genes they influence49. Distant eQTLs usually act in trans. The number of distant eQTLs that have been identified so far is much more variable between species than that of local eQTLs. In yeas ...
RNA Express Workflow - support.illumina.com
RNA Express Workflow - support.illumina.com

... expression, fold change, standard error, p-value, etc.) is reported for each gene. The script writes a table of raw counts across all replicates and plots a gene-level heat map sorted by hierarchical clustering. This heat map contains up to 5000 significantly differentially expressed genes, q < 0.05 ...
Ge´nie: literature-based gene prioritization at multi genomic scale
Ge´nie: literature-based gene prioritization at multi genomic scale

... number of publications with associated genes makes it difficult to find the required information without computational assistance. This prompted the development of computational methods to assist researchers in evaluating gene function based on analysis of the literature (5,6). However, to date, there ...
Functional tests of enhancer conservation between
Functional tests of enhancer conservation between

... and the target genes are conserved across phylogeny. The pathway for generation of GABAergic neurons is one such example. The upstream specification pathway for many GABAergic neurons in nematodes is the homeobox transcription factor UNC-30, which is orthologous to Pitx genes in mammals as well as a ...
chapter 15 - Issaquah Connect
chapter 15 - Issaquah Connect

... of the genetic loci along a particular chromosome and hypothesized that the frequency of recombinant offspring reflected the distance between genes on a chromosome.  Sturtevant predicted the farther apart two genes are, the _________ the probability a crossover will occur, and therefore, the higher ...
1. Introduction to Molecular Biology
1. Introduction to Molecular Biology

... If gene X codes for a transcription factor of gene Y, manupilating X will affect Y, but not vice versa But in Bayesian networks, X->Y and Y->X are equivalent ...
Discriminate the Falsely Predicted Protein–Coding Genes in
Discriminate the Falsely Predicted Protein–Coding Genes in

... lacking of introns, whereas more and more researches indicate the issue of gene finding in microbial genomes is far from thoroughly resolved, the annotation quality of microbial genomes has been questioned continuously [1, 2]. In most microbial genomes, it is found some annotated genes do not encode ...
Small GTP-binding protein PdRanBP regulates vascular tissue
Small GTP-binding protein PdRanBP regulates vascular tissue

... 220 that is structurally similar to the GTP-binding domains of other small GTPases. Based on these findings, PdRanBP is a conserved member of the Ras superfamily of small GTPases. In addition, three other important domains were identified in PdRanBP. Two 2Fe-2S ferredoxin-type iron-sulphur binding d ...
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Long non-coding RNA

Long non-coding RNAs (long ncRNAs, lncRNA) are non-protein coding transcripts longer than 200 nucleotides. This somewhat arbitrary limit distinguishes long ncRNAs from small regulatory RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs.
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