Inquiry into Life Twelfth Edition
... • Small molecules can act directly on the 5’UTRs of mRNAs to control their expression • Regions of 5’-UTRs capable of altering their structures to control gene expression in response to ligand binding are called riboswitches ...
... • Small molecules can act directly on the 5’UTRs of mRNAs to control their expression • Regions of 5’-UTRs capable of altering their structures to control gene expression in response to ligand binding are called riboswitches ...
Commentary: Lamarckian inheritance and
... been of lasting value, as mentioned above. Mendel on the other hand concentrated on just one problem in heredity, working steadily on it for 8 years and revealing some fundamental Laws or Principles of Heredity. He is rightly regarded as the founding father of modern genetics. Galton, an exact conte ...
... been of lasting value, as mentioned above. Mendel on the other hand concentrated on just one problem in heredity, working steadily on it for 8 years and revealing some fundamental Laws or Principles of Heredity. He is rightly regarded as the founding father of modern genetics. Galton, an exact conte ...
Do the Time-Warp: Continuous Alignment ... Expression Time-Series Data Georg Kurt Gerber UC
... needed to crack hard research problems, as well as the courage and entrepreneurial spirit needed to blaze trails in a new field. Professor Tommi Jaakkola has also been critical in the development of this thesis. He first suggested applying mixed-effects spline models to gene expression data, and sub ...
... needed to crack hard research problems, as well as the courage and entrepreneurial spirit needed to blaze trails in a new field. Professor Tommi Jaakkola has also been critical in the development of this thesis. He first suggested applying mixed-effects spline models to gene expression data, and sub ...
Phylogenetic ANOVA: The Expression Variance and
... individuals in a population or a species. This expression level variance is caused by genetic ...
... individuals in a population or a species. This expression level variance is caused by genetic ...
A conserved blueprint for the eye? - treisman lab
... onic central nervous system (toy, ey, dac), the embryonic gonad (eya), the optic lobes (toy, so, dac), the embryonic salivary duct (eyg) and the intermediate leg segments (dac).(2,3,5,6,8,21–23) Clearly, their expression is not sufficient to trigger eye development in these sites. toy, ey, eya, so, ...
... onic central nervous system (toy, ey, dac), the embryonic gonad (eya), the optic lobes (toy, so, dac), the embryonic salivary duct (eyg) and the intermediate leg segments (dac).(2,3,5,6,8,21–23) Clearly, their expression is not sufficient to trigger eye development in these sites. toy, ey, eya, so, ...
POCUS: mining genomic sequence annotation to predict disease
... Unfortunately, the literature on genetic susceptibility to disease is rich in unexpected findings and it is not unusual for novel disease genes to be counterintuitive, given the literature on the disease in question. Here we present POCUS (prioritization of candidate genes using statistics), a novel ...
... Unfortunately, the literature on genetic susceptibility to disease is rich in unexpected findings and it is not unusual for novel disease genes to be counterintuitive, given the literature on the disease in question. Here we present POCUS (prioritization of candidate genes using statistics), a novel ...
Ribosome Profiling
... according to the requirement of the cell. Therefore, the study of gene expression by analyzing entire transcripts can provide important insights into the spatial and temporal gene regulation inside a cell. Microarray and RNA sequencing (RNA-seq) are two extensively used techniques to analyze genome ...
... according to the requirement of the cell. Therefore, the study of gene expression by analyzing entire transcripts can provide important insights into the spatial and temporal gene regulation inside a cell. Microarray and RNA sequencing (RNA-seq) are two extensively used techniques to analyze genome ...
vysoké učení technické v brně molecular signature as optima of
... symptoms and treatments which are still not completely clarify in any cases. One of the most aggressive and recurring type is basal-like or let say triple negative breast cancer subtype. Also this type of breast cancer does not react on the traditional types of chemotherapy and its prediction is dif ...
... symptoms and treatments which are still not completely clarify in any cases. One of the most aggressive and recurring type is basal-like or let say triple negative breast cancer subtype. Also this type of breast cancer does not react on the traditional types of chemotherapy and its prediction is dif ...
Preferential X-chromosome inactivation, DNA
... activity. The embryos were derived from a T epi end e.e.e. PGK-IB mother and a PGK-JA father. Male embryos inherit only PGK-IB on the X chromosome from the mother. Female embryos show random inactivation in epiblast (both PGK-IA and PGK-IB are expressed) and non-random inactivation in the extraembry ...
... activity. The embryos were derived from a T epi end e.e.e. PGK-IB mother and a PGK-JA father. Male embryos inherit only PGK-IB on the X chromosome from the mother. Female embryos show random inactivation in epiblast (both PGK-IA and PGK-IB are expressed) and non-random inactivation in the extraembry ...
Analysis of alternative splicing in Drosophila genetic
... A common issue in the analysis of reporters in whole organisms is that the effects of different genotypes must be inferred from comparison of reporter signals in tissues derived from separate individuals. Such comparisons are potentially subject variations in the age, sample preparation, culture con ...
... A common issue in the analysis of reporters in whole organisms is that the effects of different genotypes must be inferred from comparison of reporter signals in tissues derived from separate individuals. Such comparisons are potentially subject variations in the age, sample preparation, culture con ...
Acute stress and hippocampal histone H3 lysine 9 trimethylation, a
... but it was associated with reductions (stress down) at only 1,438 loci (Fig. 3A) [false-discovery rate (FDR) <0.0001, P < 0.05]. When categorized by repetitive-element class, differences emerge in the enrichment of stress-up versus stress-down peaks: the autonomous long interspersed element (LINE) r ...
... but it was associated with reductions (stress down) at only 1,438 loci (Fig. 3A) [false-discovery rate (FDR) <0.0001, P < 0.05]. When categorized by repetitive-element class, differences emerge in the enrichment of stress-up versus stress-down peaks: the autonomous long interspersed element (LINE) r ...
Qβ replicase discriminates between legitimate and illegitimate
... close to one another, which favors their annealing. • These stands immediately collapse into the double helix under action of proteases and detergents that cannot affect the stability of the RNA secondary structure, but destroy or unfold the protein structure. ...
... close to one another, which favors their annealing. • These stands immediately collapse into the double helix under action of proteases and detergents that cannot affect the stability of the RNA secondary structure, but destroy or unfold the protein structure. ...
Estimating complexity and adaptation in the embryo: a
... scientic discipline, as its roots come from centuries ago from embryology and anatomy). Since the 1980's crucial discoveries (Gilbert, 1998) have improved our understanding of the developmental process in many model organisms. Most of the modern developmental biology studies use an "individualistic ...
... scientic discipline, as its roots come from centuries ago from embryology and anatomy). Since the 1980's crucial discoveries (Gilbert, 1998) have improved our understanding of the developmental process in many model organisms. Most of the modern developmental biology studies use an "individualistic ...
Caenorhabditis elegans chromosome arms are anchored to the
... Results: We determined the genomic regions associated with the nuclear transmembrane protein LEM-2 in mixedstage C. elegans embryos via chromatin immunoprecipitation. Large regions of several megabases on the arms of each autosome were associated with LEM-2. The center of each autosome was mostly fr ...
... Results: We determined the genomic regions associated with the nuclear transmembrane protein LEM-2 in mixedstage C. elegans embryos via chromatin immunoprecipitation. Large regions of several megabases on the arms of each autosome were associated with LEM-2. The center of each autosome was mostly fr ...
A nested deletion approach to generate Cre deleter mice with
... to overcome the difficulties often created by early lethal conditions, due either to particular mutations, or, even more of a concern for the future, to the combination of various mutations. Murine Hox genes provide an interesting example of the interest of this system. Mammals have 39 Hox genes enc ...
... to overcome the difficulties often created by early lethal conditions, due either to particular mutations, or, even more of a concern for the future, to the combination of various mutations. Murine Hox genes provide an interesting example of the interest of this system. Mammals have 39 Hox genes enc ...
Meristematic sculpting in fruit development
... purple zone represents an auxin maximum. The gene interactions that have been demonstrated are designated with solid lines and possible genetic interactions are indicated with a dashed line. See text for details. ...
... purple zone represents an auxin maximum. The gene interactions that have been demonstrated are designated with solid lines and possible genetic interactions are indicated with a dashed line. See text for details. ...
Extracellular matrix gene expression in the developing
... angiogenic or vasculogenic processes. With the initiation of blood flow, recruitment and diVerentiation of cells that make up the vascular wall begins in a process that is highly sensitive to local hemodynamic forces (Langille, 1996). The general histological form of the large blood vessels includes ...
... angiogenic or vasculogenic processes. With the initiation of blood flow, recruitment and diVerentiation of cells that make up the vascular wall begins in a process that is highly sensitive to local hemodynamic forces (Langille, 1996). The general histological form of the large blood vessels includes ...
Adaptive Evolution of Proteins Secreted during Sperm Maturation
... mouse–human 1.190, mouse–dog 1.368, or mouse– cow 1.442 (each representing greater than twice the median dS estimated from these respective genome pairs). Because our expression definitions were based on data collected within a single inbred strain of mice, but evolutionary rates were estimate ...
... mouse–human 1.190, mouse–dog 1.368, or mouse– cow 1.442 (each representing greater than twice the median dS estimated from these respective genome pairs). Because our expression definitions were based on data collected within a single inbred strain of mice, but evolutionary rates were estimate ...
1 Tuning of recombinant protein expression in Escherichia
... peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. ...
... peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. ...
Epigenetics in mood disorders
... dimethyl H3K9. These results implicate epigenetic mechanisms in the activity of MAO inhibitors. Eric Nestler and colleagues have experimental documentation of the associations between histone modifications and changes in behavioral function in response to antidepressant treatment and ECS in the hipp ...
... dimethyl H3K9. These results implicate epigenetic mechanisms in the activity of MAO inhibitors. Eric Nestler and colleagues have experimental documentation of the associations between histone modifications and changes in behavioral function in response to antidepressant treatment and ECS in the hipp ...
Temperature-dependent expression of virulence genes in fish
... DsrA (Kortmann and Narberhaus, 2012; Han et al., 2013). Expression of DsrA is enhanced at low temperature, resulting in base pairing with rpoS mRNA in the 5 non-co ding region, bringing about an increase in rpoS translation (Rapoila and Gottesman, 2001; Rapoila et al., 2003; McCullen et al., 2010). ...
... DsrA (Kortmann and Narberhaus, 2012; Han et al., 2013). Expression of DsrA is enhanced at low temperature, resulting in base pairing with rpoS mRNA in the 5 non-co ding region, bringing about an increase in rpoS translation (Rapoila and Gottesman, 2001; Rapoila et al., 2003; McCullen et al., 2010). ...
Controlling morpholino experiments: don`t stop making antisense
... and are therefore remarkably stable (see below), and the fact that they do not carry a negatively charged backbone means that they are less likely to interact non-specifically with other components of the cell and may be less toxic as a result. MOs do not act through an RNaseH mechanism but instead ...
... and are therefore remarkably stable (see below), and the fact that they do not carry a negatively charged backbone means that they are less likely to interact non-specifically with other components of the cell and may be less toxic as a result. MOs do not act through an RNaseH mechanism but instead ...