Supplementary Figure 1. Generation of IDH2 mutant mice. (A
... brown-like adipocytes in visceral WAT of wild-type and IDH2-/- mice. The figure shows representative data for three independent experiments. The oligonucleotides used for PCR are listed in Table S1. (F) Quantifications of proteins associated with thermogenesis in sections of BAT from wild-type and I ...
... brown-like adipocytes in visceral WAT of wild-type and IDH2-/- mice. The figure shows representative data for three independent experiments. The oligonucleotides used for PCR are listed in Table S1. (F) Quantifications of proteins associated with thermogenesis in sections of BAT from wild-type and I ...
Tutorial - Ensembl
... An Ensembl gene may have multiple transcripts reflecting alternative splicing, in this case the EPO gene only shows one transcript in Ensembl. ...
... An Ensembl gene may have multiple transcripts reflecting alternative splicing, in this case the EPO gene only shows one transcript in Ensembl. ...
The Mobile Genetic Element Alu in the Human Genome
... for Alu transcription in vivo, the vast majority of Alu elements are transcriptionally silent unless inserted into a favorable genomic location that fortuitously provides them with the 5' cis regulatory sequences. In addition, after insertion most SINEs are subject to methylation that is tissue and ...
... for Alu transcription in vivo, the vast majority of Alu elements are transcriptionally silent unless inserted into a favorable genomic location that fortuitously provides them with the 5' cis regulatory sequences. In addition, after insertion most SINEs are subject to methylation that is tissue and ...
Comparative analysis of mono(2-ethylhexyl)phthalate (MEHP) and
... different from that in the vehicle control. Moreover, the distinct separation of MEHP_D8 and MEHP_D10 data sets suggested a marked gene expression change in MEHP-treated cells during adipogenesis from D8 to D10. Next, relevance networks were used to compute comprehensive pair-wise measures of simila ...
... different from that in the vehicle control. Moreover, the distinct separation of MEHP_D8 and MEHP_D10 data sets suggested a marked gene expression change in MEHP-treated cells during adipogenesis from D8 to D10. Next, relevance networks were used to compute comprehensive pair-wise measures of simila ...
Trachemys scripta elegans Red-Eared Turtle ( Fc)
... which the secretory tail is not encoded by a separate exon but rather by the sequence immediately downstream of the CH2 exon (21). Because Igs play important roles in the adaptive immune system of all jawed vertebrates (1, 2), they have been extensively studied in various groups of animals, includin ...
... which the secretory tail is not encoded by a separate exon but rather by the sequence immediately downstream of the CH2 exon (21). Because Igs play important roles in the adaptive immune system of all jawed vertebrates (1, 2), they have been extensively studied in various groups of animals, includin ...
... Differential gene expression results in cell diversity, although how different cell identities are established early in development and maintained throughout life is still poorly understood. Most of the transcription factors required for early developmental decisions are expressed transiently, but t ...
Overview of splicing relevant databases - Stamm
... several of these needs by gathering and organizing genomic and transcriptomic data as well as providing tools allowing to predict many features in term of regulation (e.g., tissue expression). 2.2. Alternative splicing databases: common strategy Most alternative splicing databases are based on the s ...
... several of these needs by gathering and organizing genomic and transcriptomic data as well as providing tools allowing to predict many features in term of regulation (e.g., tissue expression). 2.2. Alternative splicing databases: common strategy Most alternative splicing databases are based on the s ...
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase
... of H3K4. Loss of Set1 gives rise to cells displaying unusually rapid development, characterized by precocious aggregation of cells into multicellular aggregates. Early starvation markers are abundantly expressed during growth, indicating the mutants inappropriately enter the differentiation program, ...
... of H3K4. Loss of Set1 gives rise to cells displaying unusually rapid development, characterized by precocious aggregation of cells into multicellular aggregates. Early starvation markers are abundantly expressed during growth, indicating the mutants inappropriately enter the differentiation program, ...
A catalogue of imprinted genes and parent-of
... strongest evidence is provided by direct detection of parent-of-origin-specific transcription from a gene, for example as seen with SNRPN which is only transcribed from the paternally inherited allele. Detection of imprinted gene expression in some tissues does not necessarily indicate that the gene ...
... strongest evidence is provided by direct detection of parent-of-origin-specific transcription from a gene, for example as seen with SNRPN which is only transcribed from the paternally inherited allele. Detection of imprinted gene expression in some tissues does not necessarily indicate that the gene ...
Slide 1
... human leukocyte antigen (HLA) loci on the short arm of chromosome 6. Age at onset, clinical features, and course of the disease are described. Although the mean age of onset was 34 years in this family, in 6 of 41 affected individuals onset was below 15 years of age and was accompanied by the unique ...
... human leukocyte antigen (HLA) loci on the short arm of chromosome 6. Age at onset, clinical features, and course of the disease are described. Although the mean age of onset was 34 years in this family, in 6 of 41 affected individuals onset was below 15 years of age and was accompanied by the unique ...
Fig. 1 - Repositorio Académico
... analysis (Zúñiga et al., 2009) to isolate a set of transcripts that are differentially expressed between gastrulating and blastoderm embryos, among them we identified gene CG6234 and showed that it is specifically expressed along the dorsal midline of the early embryo and in the differentiated amniose ...
... analysis (Zúñiga et al., 2009) to isolate a set of transcripts that are differentially expressed between gastrulating and blastoderm embryos, among them we identified gene CG6234 and showed that it is specifically expressed along the dorsal midline of the early embryo and in the differentiated amniose ...
University of Groningen Methionine
... Impact Statement This study demonstrates methionine-mediated gene regulation in Streptococcus pneumoniae and identifies methionine transport and biosynthesis genes. S. pneumoniae is a human nasopharyngeal pathogen that is responsible for millions of deaths each year. Methionine is one of the importa ...
... Impact Statement This study demonstrates methionine-mediated gene regulation in Streptococcus pneumoniae and identifies methionine transport and biosynthesis genes. S. pneumoniae is a human nasopharyngeal pathogen that is responsible for millions of deaths each year. Methionine is one of the importa ...
Full Text - Harvard University
... Phenotype. Genotype refers to the all the genetic information that constitutes an organism. Phenotype refers to all the observable traits or characteristics of that organism. Considering gene expression as an observable trait, the main focus of all the reverse engineering methods is to model the com ...
... Phenotype. Genotype refers to the all the genetic information that constitutes an organism. Phenotype refers to all the observable traits or characteristics of that organism. Considering gene expression as an observable trait, the main focus of all the reverse engineering methods is to model the com ...
What is the Molecular Clock? Components of the Molecular Clock
... in a series of negative feedback loops. These transcription factors bind to DNA regions called promoters, which are DNA sequences found near a gene. The binding of a transcription factor to a promoter may turn the gene on or off, thereby controlling production of proteins. In some cases, a heterodim ...
... in a series of negative feedback loops. These transcription factors bind to DNA regions called promoters, which are DNA sequences found near a gene. The binding of a transcription factor to a promoter may turn the gene on or off, thereby controlling production of proteins. In some cases, a heterodim ...
Comparative analysis of peanut NBS‐LRR gene clusters suggests
... (BACs) containing a high density of R genes. Analysis of two genomic regions identified several TIR-NBS-LRR (Toll-interleukin-1 receptor, nucleotide-binding site, leucine-rich repeat) resistance gene analogs or gene fragments. We reconstructed their evolutionary history characterized by tandem dupli ...
... (BACs) containing a high density of R genes. Analysis of two genomic regions identified several TIR-NBS-LRR (Toll-interleukin-1 receptor, nucleotide-binding site, leucine-rich repeat) resistance gene analogs or gene fragments. We reconstructed their evolutionary history characterized by tandem dupli ...
A gene expression atlas of a bicoid-depleted
... In developing embryos, gene regulatory networks drive cells towards discrete terminal fates, a process called canalization. We studied the behavior of the anterior-posterior segmentation network in Drosophila melanogaster embryos by depleting a key maternal input, bicoid (bcd), and measuring gene ex ...
... In developing embryos, gene regulatory networks drive cells towards discrete terminal fates, a process called canalization. We studied the behavior of the anterior-posterior segmentation network in Drosophila melanogaster embryos by depleting a key maternal input, bicoid (bcd), and measuring gene ex ...
Nucleotide Polymorphisms in the 2 Gene Define
... different levels of a2b1 revealed two linked nucleotide polymorphisms, separated by almost seventy nucleotides, at bp 807 and 873 in the a2 coding region. These were the only two nucleotide polymorphisms identified within the ,3.5-kb a2 coding region that consistently varied among the samples studie ...
... different levels of a2b1 revealed two linked nucleotide polymorphisms, separated by almost seventy nucleotides, at bp 807 and 873 in the a2 coding region. These were the only two nucleotide polymorphisms identified within the ,3.5-kb a2 coding region that consistently varied among the samples studie ...
Quantitative genetics of gene expression during fruit fly - EMBL-EBI
... to identify genetic variants associated with many diseases as well as quantitative phenotypes, by exploiting naturally occurring genetic variation in large cohorts of individuals. More recently, the GWAS approach has also been applied to highthroughput RNA sequencing (RNA-seq) data in order to find ...
... to identify genetic variants associated with many diseases as well as quantitative phenotypes, by exploiting naturally occurring genetic variation in large cohorts of individuals. More recently, the GWAS approach has also been applied to highthroughput RNA sequencing (RNA-seq) data in order to find ...
pdf file - Department of Statistics
... significance of all 4096 possible hexamers, the null hypothesis being that the hexamer is not an ESE. A statistic was formed based on the location of the hexamers in 4817 human genes where the exon-intron structure has been well characterized. The end product is a p-value associated with each of th ...
... significance of all 4096 possible hexamers, the null hypothesis being that the hexamer is not an ESE. A statistic was formed based on the location of the hexamers in 4817 human genes where the exon-intron structure has been well characterized. The end product is a p-value associated with each of th ...
GCF (K-13): sc-133418 - Santa Cruz Biotechnology
... GCF (GC-rich sequence DNA-binding factor), also known as C2orf3 (chromosome 2 open reading frame 3), transcription factor 9 (TCF-9) or DNABF, is a 781 amino acid nuclear protein that belongs to the GCF family. Widely expressed, GCF binds the GC-rich sequences of β-Actin, EGFR and calciumdependent pr ...
... GCF (GC-rich sequence DNA-binding factor), also known as C2orf3 (chromosome 2 open reading frame 3), transcription factor 9 (TCF-9) or DNABF, is a 781 amino acid nuclear protein that belongs to the GCF family. Widely expressed, GCF binds the GC-rich sequences of β-Actin, EGFR and calciumdependent pr ...
Lack of expression of XIST from a small ring X chromosome
... with the variant sequence being on the paternally inherited ring chromosome that is not present in all of her cells. The patient's paternal grandmother was heterozygous for the variant (Figure 4C). Over 100 X chromosomes from male and female controls were examined for this variant using the BanI ass ...
... with the variant sequence being on the paternally inherited ring chromosome that is not present in all of her cells. The patient's paternal grandmother was heterozygous for the variant (Figure 4C). Over 100 X chromosomes from male and female controls were examined for this variant using the BanI ass ...
Genetic Regulation of Meristem Maintenance and Organ
... Molecular genetic studies in Arabidopsis thaliana over the last 15 years have produced a wealth of information that has considerably advanced our understanding of plant development at the molecular level. Among these advances, the ABC model of floral organ specification and the negative feedback mod ...
... Molecular genetic studies in Arabidopsis thaliana over the last 15 years have produced a wealth of information that has considerably advanced our understanding of plant development at the molecular level. Among these advances, the ABC model of floral organ specification and the negative feedback mod ...