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ARTICLE IN PRESS
ARTICLE IN PRESS

... memory for complex spatiotemporal trajectories (Fig. 1B). For example, the 8-arm radial maze task requires that rats visit 8 different arms without making an error by repeating an arm entry, and the number of arm re-entries is increased by fornix lesions [87,131]. The rat could avoid the error of re ...
The Classical Genetic Switch in Lambda Phage- Lysis and
The Classical Genetic Switch in Lambda Phage- Lysis and

... states in the lambda phage, we focus on two regulatory genes CI and cro and a regulatory region OR called the right operator as shown in Fig 3. During the lysogeny phase CI is switched ON and cro is OFF. The operator OR is constituted of three binding sites ORI, ORII and ORIII which overlap two prom ...
The genome-scale interplay amongst xenogene silencing
The genome-scale interplay amongst xenogene silencing

... and indels were detected using VarScan (14). SNPs supported by more than 20% of reads from the population genome sequencing experiments are listed in Supplementary Figure S2 and in Supplementary Table S1; these lists include only those mutations which were not detected in the parental genome of Δhns ...
Molecular Cloning of Streptococcus bovis Lactose
Molecular Cloning of Streptococcus bovis Lactose

... identity. The catabolite activator protein binding sequence, present in the E. coli promoter, was absent from the corresponding S . bovis region. ...
Molecular Mechanisms of Learning and Memory
Molecular Mechanisms of Learning and Memory

... • Consequences of genetic deletions (e.g., CaMK11 subunit) • Advances (temporal and spatial control) • Limitations of using genetic mutants to study LTP/learning: secondary consequences ...
Modified Mendelian ratios
Modified Mendelian ratios

... • The mouse must be: A/_; b/b; C/_; d/d; s/s • Because to be dilute= dd, to be spotted= ss, to be cinnamon= A/_;b/b and C/_ ...
Full Text  - The International Journal of Developmental Biology
Full Text - The International Journal of Developmental Biology

... netrin and the unc40 homolog, frazzled. Both are involved in motoneuron guidance. frazzled is expressed on motoneurons that use a netrin source for proper orientation (Kolodziej et al., 1996). ...
Functional Consequences of a SDHB Gene Mutation in an
Functional Consequences of a SDHB Gene Mutation in an

... We have previously surveyed the consequences of an inactivating SDHD germline mutation associated with a loss of wild-type allele, which participates in hereditary paraganglioma development (5). The direct consequence of the SDHD mutation was a complete loss of electron transport chain complex II ac ...
Inheritance - Fiendishlyclever
Inheritance - Fiendishlyclever

... • Once the glue is dry, put glue on the other tab of each rung and stick them to the corresponding numbered position on spine B. This is the tricky part because you'll have to support both spines while the glue is drying. Once again, this is where pegs will be a BIG help. • When you've completed you ...
A Sunflower Helianthinin Gene Upstream Sequence
A Sunflower Helianthinin Gene Upstream Sequence

... storage protein in the French bean. Phaseolin and helianthinin genes are expressed with very similar developmental patterns (Alien, Nessler, and Thomas, 1985; SenguptaGopalan et al., 1985). French bean nuclear proteins have been shown to bind to sequences located within an SsplDral upstream phaseoli ...
Special Feature —Manipulating Genes to Understand
Special Feature —Manipulating Genes to Understand

... cells can be reintroduced into preimplantation mouse blastocysts, where they become part of the inner cell mass. These blastocysts can be reimplanted into the uterus of a foster mother, where they will develop into genetically mosaic animals. The mosaicism is due to a mixture of parental blastocyst- ...
synthesis Gene Cluster of Streptomyces clavuligerus
synthesis Gene Cluster of Streptomyces clavuligerus

... argE gene has been located by sequencing the B. subtilis genome (Kunst et al., 1997) but its relation with the cyclic pathway of arginine biosynthesis in this bacterium (Figure 1) remains to be elucidated; the regulatory gene ahrC encoding the arginine biosynthesis repressor (North et al., 1989) is ...
Memory Consolidation and REM Sleep
Memory Consolidation and REM Sleep

... Aldous Huxley's Brave New World considers the possibility of humans learning simply by listening to recorded messages played during their sleep. Can learning really be this simple? What is the role of sleep in learning and memory? It is known that sleep exists in two phases, REM and Non REM sleep. I ...
Supplemental Information for Free D
Supplemental Information for Free D

... segments per neuron chosen in branch orders 2–4 of apical and basal dendrites. All protrusions, with or without bulbous expansion, but no longer than 1.2 μm, were counted as spines if they were continuous with the dendritic shaft. The average spine density (number of spines per 10-μm-long segment) w ...
Thinking of Biology - Oxford Academic
Thinking of Biology - Oxford Academic

... "...genes do not have to be expressed Section of chromosome expanded to active chromatinstecef to be present. The somatic cells of a the cell multicellular organism all have the same genes, but particular cell types express only some of them" (Epp Figure 1. Schematicrepresentationof some transcripti ...
Tweak to molecular scissors cuts path to turn on genes —
Tweak to molecular scissors cuts path to turn on genes —

... These cells help to coordinate immune responses in the gut and so are likely to influence the composition of the microbial community. The types of resident bacteria also vary between people and mice. Both microbiomes are dominated by two major bacterial groups: bacteroidetes and firmicutes. But thei ...
File
File

... Transcription of Eukaryotes • Differ from prokaryotes (i) Eukaryotic cells possess three different RNA polymerases, each of which transcribes a different class of RNA and recognizes a different type of promoter (ii) Another difference is in the nature of promoter recognition and initiation. Many pr ...
Enhanced intrinsic excitability and EPSP
Enhanced intrinsic excitability and EPSP

... with the dendritic shaft. The primary branch to the apical dendrite (main shaft) of the area ...
Leveraging additional knowledge to support coherent bicluster
Leveraging additional knowledge to support coherent bicluster

... To exceed this limitation, biclustering approaches have been proposed [25]. They examine gene and sample dimensions simultaneously, enabling the discovery of coherent and meaningful biclusters, i.e., potentially overlapping groups of genes showing similar activity patterns under a specific subset of ...
Introduction to Bioinformatics.
Introduction to Bioinformatics.

... * Therefore it is usefull to monitor the genome-wide expression of S. cerevisiae in time, including the diauxic shift. * Such a conveyor belt of coupled expressed genes is called a genetic pathway * This monitoring can be done with microarrays, the foremost important tools in bioinformatics. * Other ...
Biol115_2014_Lecture 10_Prokaryotic Gene Regulation
Biol115_2014_Lecture 10_Prokaryotic Gene Regulation

... Operons: The basic concept" •  A cluster of functionally related genes can be under coordinated control by a single on-off “switch”" •  An operon is the entire stretch of DNA that includes the operator, the promoter, and the genes that they control" •  The regulatory “switch” is a segment of DNA ca ...
Neural changes underlying the development of
Neural changes underlying the development of

... to determine whether or not objects have been previous viewed and, if viewed, with what border color they were presented (Fig. 1). In some tasks, it is possible to assess the contribution of episodic recollection to performance, by either asking to participants to characterize their subjective memor ...
Barley Cbf3 Gene Identification, Expression Pattern, and Map Location
Barley Cbf3 Gene Identification, Expression Pattern, and Map Location

... of the HvCbf3 gene, we used real-time reverse transcription PCR. Total RNA was isolated from barley seedling shoots sampled at different times throughout a chilling or ABA treatment. For comparison, mRNAs from the same RNA samples were amplified with primers specific for known chilling- and ABAinduc ...
Extensions of Mendelian Genetics
Extensions of Mendelian Genetics

... Wild-type is used to indicate the normal state, and is often designated as a superscript wt or +. A loss of function mutation may be designated with a superscript -. Remember the Ames test? The strain of Salmonella used was his-, indicating a mutation in the histidine biosynthesis pathway that resul ...
recognition memory: what are the roles of the perirhinal cortex and
recognition memory: what are the roles of the perirhinal cortex and

... C-FOS is commonly expressed when neurons are active ...
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Epigenetics in learning and memory

While the cellular and molecular mechanisms of learning and memory have long been a central focus of neuroscience, it is only in recent years that attention has turned to the epigenetic mechanisms behind the dynamic changes in gene transcription responsible for memory formation and maintenance. Epigenetic gene regulation often involves the physical marking (chemical modification) of DNA or associated proteins to cause or allow long-lasting changes in gene activity. Epigenetic mechanisms such as DNA methylation and histone modifications (methylation, acetylation, and deacetylation) have been shown to play an important role in learning and memory.
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