1. Introduction to Molecular Biology
... clustering of gene expression & sequence analysis) and finding transcription factors that bind to the corresponding promoters (through structural/sequence analysis) EECS 600: Systems Biology & Bioinformatics ...
... clustering of gene expression & sequence analysis) and finding transcription factors that bind to the corresponding promoters (through structural/sequence analysis) EECS 600: Systems Biology & Bioinformatics ...
19.1 CONSTITUTIVE, INDUCIBLE AND REPRESSIBLE GENE
... The Lac promoter is intrinsically "weak" because of a poor match to consensus sequence of the sigma factor. This is important for positive regulation by CAP. The mechanism by which glucose regulates adenyl cyclase activity in this case is not yet known. It is interesting to note that cAMP is found a ...
... The Lac promoter is intrinsically "weak" because of a poor match to consensus sequence of the sigma factor. This is important for positive regulation by CAP. The mechanism by which glucose regulates adenyl cyclase activity in this case is not yet known. It is interesting to note that cAMP is found a ...
Chapter 14: Gene Transcription and RNA Modification
... is a regulatory sequence that plays a central role in transcriptional regulation. There are two things that you should focus on with regards to the promoter. The first is the numbering of nucleotides (Figure 14.4) and the second is the concept of a consensus sequence (Figure 14.5). Notice that not a ...
... is a regulatory sequence that plays a central role in transcriptional regulation. There are two things that you should focus on with regards to the promoter. The first is the numbering of nucleotides (Figure 14.4) and the second is the concept of a consensus sequence (Figure 14.5). Notice that not a ...
Associations between polymorphisms of growth hormone releasing
... from other species were described. The sequence of bovine GRF (1-44-NH2) differs from human GRF by only five residues (ESCH et al., 1983). MAYO et al. (1985) isolated and characterised the entire structure of the human gene encoding GHRH. The gene consists of five exons separated by interval introns ...
... from other species were described. The sequence of bovine GRF (1-44-NH2) differs from human GRF by only five residues (ESCH et al., 1983). MAYO et al. (1985) isolated and characterised the entire structure of the human gene encoding GHRH. The gene consists of five exons separated by interval introns ...
PDF
... The process of generating differentiated cell types performing specific effector functions from their respective undifferentiated precursors is dictated by extracellular signals, which alter the host cell’s capacity to perform cellular functions. One major mechanism for bringing about such changes i ...
... The process of generating differentiated cell types performing specific effector functions from their respective undifferentiated precursors is dictated by extracellular signals, which alter the host cell’s capacity to perform cellular functions. One major mechanism for bringing about such changes i ...
Dopamine: a potential substrate for synaptic plasticity and memory
... Contrary to CA1, just a few studies have investigated DA modulation of LTP in the dentate gyrus, even if DA innervation is also present in a small amount but to a similar extent in this hippocampal region. Yanagihashi and Ishikawa (1992) found that LTP of the population spike in the dentate gyrus di ...
... Contrary to CA1, just a few studies have investigated DA modulation of LTP in the dentate gyrus, even if DA innervation is also present in a small amount but to a similar extent in this hippocampal region. Yanagihashi and Ishikawa (1992) found that LTP of the population spike in the dentate gyrus di ...
Recombinant DNA Technology
... damaged by mutagens such as toxic chemicals, UV light, or viruses. This process prevents the development of tumors by stopping cells with damaged DNA from undergoing mitosis and passing down this damaged DNA to daughter cells. If it is determined that the DNA can be repaired p53 will activate other ...
... damaged by mutagens such as toxic chemicals, UV light, or viruses. This process prevents the development of tumors by stopping cells with damaged DNA from undergoing mitosis and passing down this damaged DNA to daughter cells. If it is determined that the DNA can be repaired p53 will activate other ...
Why does the giraffe have such a long neck? Analysis zeroes in on
... Evolution is the theory that species change over time to become better at living in their environment. The changes that make the animals' bodies better suited to their environment are called adaptations. Giraffes' bodies are short to support their long necks. Their legs grow super straight to keep t ...
... Evolution is the theory that species change over time to become better at living in their environment. The changes that make the animals' bodies better suited to their environment are called adaptations. Giraffes' bodies are short to support their long necks. Their legs grow super straight to keep t ...
Differential Gene Expression Differentially Expressed Genes
... The BH procedure is a step-up procedure that provides strong control of the FDR. The key to understanding/interpretation is to understand the meaning of the FDR. The FDR indicates the expected (average) proportion of ’discoveries’ (ie, rejected null hypotheses) that are ’false discoveries’ (ie, the ...
... The BH procedure is a step-up procedure that provides strong control of the FDR. The key to understanding/interpretation is to understand the meaning of the FDR. The FDR indicates the expected (average) proportion of ’discoveries’ (ie, rejected null hypotheses) that are ’false discoveries’ (ie, the ...
Operant conditioning in invertebrates
... B51 activity during a bite, they show the same biophysical changes as those seen after operant conditioning [30]. These results are consistent with the view that during this form of operant conditioning, a dopamine-mediated food-reward is contingent on activity in B51 during the rewarded behavior. ...
... B51 activity during a bite, they show the same biophysical changes as those seen after operant conditioning [30]. These results are consistent with the view that during this form of operant conditioning, a dopamine-mediated food-reward is contingent on activity in B51 during the rewarded behavior. ...
Predicting TF affinities to Promoters of tissue specific genes
... the previous findings the first four genes have SRF predicted as the top regulator (see Table 5.2). The latter two genes, which encode CRX and E2F2, served as a control as they are not SRF targets but rather encode other autoregulating transcription factors that bind directly to their own promoters ...
... the previous findings the first four genes have SRF predicted as the top regulator (see Table 5.2). The latter two genes, which encode CRX and E2F2, served as a control as they are not SRF targets but rather encode other autoregulating transcription factors that bind directly to their own promoters ...
Fooyin University
... studied. Leaves, roots, and panicles were cut and treated with salt, sorbitol, 4℃, and 45℃ for 24hr, respectively, before GUS staining. At present, 80 lines (~4.5%) had been obtained from 1800 mutants screening. Among the 80 lines we selected, 13 lines showed constitutive expression, 47 lines showed ...
... studied. Leaves, roots, and panicles were cut and treated with salt, sorbitol, 4℃, and 45℃ for 24hr, respectively, before GUS staining. At present, 80 lines (~4.5%) had been obtained from 1800 mutants screening. Among the 80 lines we selected, 13 lines showed constitutive expression, 47 lines showed ...
- Wiley Online Library
... Functioning neural circuits require synaptic connections capable of strengthening or weakening in response to activity. This plasticity, measured electrophysiologically as the long-term potentiation or depression of synaptic strength (LTP/D), is particularly important for experience-dependent memory ...
... Functioning neural circuits require synaptic connections capable of strengthening or weakening in response to activity. This plasticity, measured electrophysiologically as the long-term potentiation or depression of synaptic strength (LTP/D), is particularly important for experience-dependent memory ...
Slides
... McShane LM, Radmacher MD, Freidlin B, Yu R, Li MC, Simon R. (2002). Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data. Bioinformatics 18(11):1462-9. ...
... McShane LM, Radmacher MD, Freidlin B, Yu R, Li MC, Simon R. (2002). Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data. Bioinformatics 18(11):1462-9. ...
PHYSIOLOGICAL AND POPULATION ASPECTS OF BEHAVIOR
... Implicit in the discussion thus far is the hypothesis that genetic effects on behavior are mediated at the molecular level, either through an effect on structure of a gene product, or through regulation of the output of gene product. To some this view may seem too restricting as it seems to leave no ...
... Implicit in the discussion thus far is the hypothesis that genetic effects on behavior are mediated at the molecular level, either through an effect on structure of a gene product, or through regulation of the output of gene product. To some this view may seem too restricting as it seems to leave no ...
Allele- and parent-of-origin-specific effects on expression of the
... chromosomes contribute equally (i.e., are expressed equally), to the development of the offspring (Saupe, 2012). However, departures from this model occur, and the expression of some genes has been shown to be governed by unequal allelic contributions, which may bias such predictions. Allele-specifi ...
... chromosomes contribute equally (i.e., are expressed equally), to the development of the offspring (Saupe, 2012). However, departures from this model occur, and the expression of some genes has been shown to be governed by unequal allelic contributions, which may bias such predictions. Allele-specifi ...
Chronic Administration of Statins Alters Multiple Gene Expression
... Our overall hypothesis was that the action of statins in the brain is not fully explainable by inhibition of the HMG-CoA reductase pathway but involves multiple pathways. We used microarray and RT-PCR to identify those gene expression pathways in cerebral cortex of mice treated with either lovastati ...
... Our overall hypothesis was that the action of statins in the brain is not fully explainable by inhibition of the HMG-CoA reductase pathway but involves multiple pathways. We used microarray and RT-PCR to identify those gene expression pathways in cerebral cortex of mice treated with either lovastati ...
Ingenuity Upstream Regulator Analysis in IPA®
... sign of the calculated z‐score will reflect the overall predicted activation state of the regulator (<0: inhibited, >0: activated). In practice, z‐scores greater than 2 or smaller than ‐2 can be considered significant. Note that in the case where the transcriptional regulator is encoded by a ge ...
... sign of the calculated z‐score will reflect the overall predicted activation state of the regulator (<0: inhibited, >0: activated). In practice, z‐scores greater than 2 or smaller than ‐2 can be considered significant. Note that in the case where the transcriptional regulator is encoded by a ge ...
FOXP2 in focus: what can genes tell us about speech and language?
... their search for the gene that was damaged, geneticists tried to correlate the distribution of a set of ‘markers’ - small stretches of DNA of known location that tend to vary between individuals - with the distribution of the disorder among members of the KE family [13]. This led them to a small reg ...
... their search for the gene that was damaged, geneticists tried to correlate the distribution of a set of ‘markers’ - small stretches of DNA of known location that tend to vary between individuals - with the distribution of the disorder among members of the KE family [13]. This led them to a small reg ...
Sarah Pulliam
... both young and old mice. Blasco et al. concluded that the s-Arf/p53 mice live longer due to an antioxidant affect created when both the Arf and p53 genes are over expressed at the same time. In another study, Pinkston, et al. found the same results in Caenorhabditis elegans, a nematode worm. Just a ...
... both young and old mice. Blasco et al. concluded that the s-Arf/p53 mice live longer due to an antioxidant affect created when both the Arf and p53 genes are over expressed at the same time. In another study, Pinkston, et al. found the same results in Caenorhabditis elegans, a nematode worm. Just a ...
Bioinformatics 3 V7 * Function Annotation, Gene Regulation
... Left: Protein – DNA contacts involve many arginine (R) and lysine (K) residues ...
... Left: Protein – DNA contacts involve many arginine (R) and lysine (K) residues ...
Axial homeosis and appendicular skeleton defects in mice with a
... of the limb bud (Tickle et al., 1975; Saunders, 1977). Although the nature of this signal and how it is distributed along the AP axis of the limb has not been defined, there is current excitement that sonic hedgehog might be the long sought signaling molecule (Echelard et al., 1993; Riddle et al., 1 ...
... of the limb bud (Tickle et al., 1975; Saunders, 1977). Although the nature of this signal and how it is distributed along the AP axis of the limb has not been defined, there is current excitement that sonic hedgehog might be the long sought signaling molecule (Echelard et al., 1993; Riddle et al., 1 ...
Genes
... boxes to a given ortholog group is representative of how much of the ortholog is fused and which region. The fused ortholog groups are labelled along the deletion box connecting the fragments. The absence of a deletion box in a gene fusion indicates that the deletion that connects the two ORFs is on ...
... boxes to a given ortholog group is representative of how much of the ortholog is fused and which region. The fused ortholog groups are labelled along the deletion box connecting the fragments. The absence of a deletion box in a gene fusion indicates that the deletion that connects the two ORFs is on ...