Lec 11 - Development of e
... more proteins. They are usually very long sequences of nucleotides including several thousand base pairs. ...
... more proteins. They are usually very long sequences of nucleotides including several thousand base pairs. ...
Immunogenetics
... Why did the amino acid sequencing of antibody light chains lead Dryer and Bennet to abandon the one gene- one polypeptide theory and propose that two genes code for a single polypeptide? ...
... Why did the amino acid sequencing of antibody light chains lead Dryer and Bennet to abandon the one gene- one polypeptide theory and propose that two genes code for a single polypeptide? ...
TaWRKY70 transcription factor in wheat QTL-2DL regulates
... Fusarium head blight (FHB) is one of the major constraints in wheat and barley production. Several methods have been used to manage FHB in wheat, among which the use of FHB resistant cultivars is considered to be the most efficient, economic and environmental friendly method1. More than 200 QTL hav ...
... Fusarium head blight (FHB) is one of the major constraints in wheat and barley production. Several methods have been used to manage FHB in wheat, among which the use of FHB resistant cultivars is considered to be the most efficient, economic and environmental friendly method1. More than 200 QTL hav ...
Investigation 1: Identify the Transcriptional Unit
... the 5' cap. These sequences (or “reads”) can then be mapped against the genomic assembly, and the TSSs will show higher read density than the rest of the genome. The modENCODE project summarizes these experimental data to produce a set of predicted TSSs; these predictions are shown in the "TSS Annot ...
... the 5' cap. These sequences (or “reads”) can then be mapped against the genomic assembly, and the TSSs will show higher read density than the rest of the genome. The modENCODE project summarizes these experimental data to produce a set of predicted TSSs; these predictions are shown in the "TSS Annot ...
RNAi in Plants: An Argonaute-Centered View
... loading rule. However, regardless of the identities of their 59 nucleotides, DCL3-dependent lmiRNAs are recruited by AGO4 clade proteins. The specificity of sRNA sorting between AGO1 and AGO4 clade proteins is unlikely to be determined by the length of the sRNAs, as both AGO1 and AGO4 clade proteins ...
... loading rule. However, regardless of the identities of their 59 nucleotides, DCL3-dependent lmiRNAs are recruited by AGO4 clade proteins. The specificity of sRNA sorting between AGO1 and AGO4 clade proteins is unlikely to be determined by the length of the sRNAs, as both AGO1 and AGO4 clade proteins ...
Verbal memory in mesial temporal lobe epilepsy
... pre-surgical decision making, and the principal paradigm for interpreting neurocognitive outcome (Baxendale, 2008). The material-specificity model is not as straightforward as it might have appeared. It implicitly embodies a specific stance towards the structure of verbal and non-verbal memory, and th ...
... pre-surgical decision making, and the principal paradigm for interpreting neurocognitive outcome (Baxendale, 2008). The material-specificity model is not as straightforward as it might have appeared. It implicitly embodies a specific stance towards the structure of verbal and non-verbal memory, and th ...
Using Mice to Dissect Genetic Factors in Atherosclerosis
... polymorphic genetic markers already typed for those strains, chromosomal loci that segregate with the trait of interest can be identified. In general, RI mapping has had low power and precision to detect QTLs, mainly owing to the small number of available strains in each set. Recently, Williams et a ...
... polymorphic genetic markers already typed for those strains, chromosomal loci that segregate with the trait of interest can be identified. In general, RI mapping has had low power and precision to detect QTLs, mainly owing to the small number of available strains in each set. Recently, Williams et a ...
Summary 121 Summary The Hox genes form a subset of the
... number of genes present in a cluster varies between animal species; the number of clusters in each species also varies. The Hox clusters are thought to have arisen by tandem duplication of a single gene, followed, in vertebrates, by duplication of the cluster itself. As a consequence, Hox genes occu ...
... number of genes present in a cluster varies between animal species; the number of clusters in each species also varies. The Hox clusters are thought to have arisen by tandem duplication of a single gene, followed, in vertebrates, by duplication of the cluster itself. As a consequence, Hox genes occu ...
Involvement of respiratory chain in biofilm formation in - HAL
... strain seemed to start losing its structure after 7 hours. Quantiication of P. gingivalis in dynamic bioilm (Table) showed that the ∆fnr strain formed a thicker bioilm with higher biomass that wild type strain. ∆cydAB mutant strain seemed to have a similar behaviour to wildtype strain. ...
... strain seemed to start losing its structure after 7 hours. Quantiication of P. gingivalis in dynamic bioilm (Table) showed that the ∆fnr strain formed a thicker bioilm with higher biomass that wild type strain. ∆cydAB mutant strain seemed to have a similar behaviour to wildtype strain. ...
Identification of a Novel Streptococcal Gene
... gene expression (4, 25, 37, 67). Remarkably, SOS-induced error-prone DnaE2 polymerase, by its mutagenic activity, contributes to the ability of Mycobacterium tuberculosis to persist and develop antibiotic resistance during infection (9). The genus Streptococcus includes species that are part of the ...
... gene expression (4, 25, 37, 67). Remarkably, SOS-induced error-prone DnaE2 polymerase, by its mutagenic activity, contributes to the ability of Mycobacterium tuberculosis to persist and develop antibiotic resistance during infection (9). The genus Streptococcus includes species that are part of the ...
module 2: transcription part i
... the 5' cap. These sequences (or “reads”) can then be mapped against the genomic assembly, and the TSSs will show higher read density than the rest of the genome. The modENCODE project summarizes these experimental data to produce a set of predicted TSSs; these predictions are shown in the "TSS Annot ...
... the 5' cap. These sequences (or “reads”) can then be mapped against the genomic assembly, and the TSSs will show higher read density than the rest of the genome. The modENCODE project summarizes these experimental data to produce a set of predicted TSSs; these predictions are shown in the "TSS Annot ...
FEATURE SELECTION = GENE SELECTION
... • This domination of the univariate approach can be explained by a number of reasons: – the output provided by univariate gene rankings is intuitive and easy to understand. – the gene ranking output could fulfill the objectives and expectations that bio-domain experts have when wanting to subsequent ...
... • This domination of the univariate approach can be explained by a number of reasons: – the output provided by univariate gene rankings is intuitive and easy to understand. – the gene ranking output could fulfill the objectives and expectations that bio-domain experts have when wanting to subsequent ...
Molecular studies on an ancient gene encoding
... and which established the concept of a molecular chronometer, was cytochrome c [2]. Although its analysis extended the understanding of the eukaryotic branch of the tree, it has been evolving too fast to be used at the earlier phylogenetic levels. Furthermore, this molecule is not found in many bact ...
... and which established the concept of a molecular chronometer, was cytochrome c [2]. Although its analysis extended the understanding of the eukaryotic branch of the tree, it has been evolving too fast to be used at the earlier phylogenetic levels. Furthermore, this molecule is not found in many bact ...
Molecular Dynamics of a Presynaptic Active Zone
... Generation of Munc13-1–EYFP KIs. The targeting vector for the generation of Munc13-1–EYFP KIs was constructed on the basis of a 15 kb genomic clone in pBluescript (pM13-1-3⬘), which had been isolated from a FIXII genomic library of the SV129 mouse strain (Stratagene, La Jolla, CA). In the targeting ...
... Generation of Munc13-1–EYFP KIs. The targeting vector for the generation of Munc13-1–EYFP KIs was constructed on the basis of a 15 kb genomic clone in pBluescript (pM13-1-3⬘), which had been isolated from a FIXII genomic library of the SV129 mouse strain (Stratagene, La Jolla, CA). In the targeting ...
The Functional Organization of the Vestigial Locus in Drosophila
... the phenotypes produced by vg alleles range from those which are homozygous wild type through nicked, notched, or strap wing phenotypes to the classical, more extreme alleles (described in Lindsley and Grell 1968; Williams and Bell 1988). Bownes and Roberts (1981b) have proposed that the cell death ...
... the phenotypes produced by vg alleles range from those which are homozygous wild type through nicked, notched, or strap wing phenotypes to the classical, more extreme alleles (described in Lindsley and Grell 1968; Williams and Bell 1988). Bownes and Roberts (1981b) have proposed that the cell death ...
Nkx5 genes in inner ear development and genome evolution
... Adamska, M., Wolff, A., Kreusler, M., Wittbrodt, J., Braun, T. and Bober, E. (manuscript in preparation) Five Nkx5 genes show differential expression patterns in anlagen of sensory organs in medaka. Insight into evolution of the Nkx5 family Amores, A., Force, A., Yan, Y. L., Joly, L., Amemiya, C., F ...
... Adamska, M., Wolff, A., Kreusler, M., Wittbrodt, J., Braun, T. and Bober, E. (manuscript in preparation) Five Nkx5 genes show differential expression patterns in anlagen of sensory organs in medaka. Insight into evolution of the Nkx5 family Amores, A., Force, A., Yan, Y. L., Joly, L., Amemiya, C., F ...
Bridging the transgenerational gap with epigenetic memory
... members of the COMPASS complex, because manipulation of other longevity-promoting pathways, such as the insulin signaling and mitochondrial pathways, or other chromatin regulators, did not show a transgenerational inheritance of long life [27]. These findings show that manipulation of specific chrom ...
... members of the COMPASS complex, because manipulation of other longevity-promoting pathways, such as the insulin signaling and mitochondrial pathways, or other chromatin regulators, did not show a transgenerational inheritance of long life [27]. These findings show that manipulation of specific chrom ...
http://doc.rero.ch
... Pavlovian fear conditioning is a paradigm in which an initially neutral stimulus such as a tone (conditioned stimulus, CS), through the pairing with an aversive unconditioned stimulus (US) such as a mild foot-shock, acquires aversive properties and comes to elicit a fear related freezing response. C ...
... Pavlovian fear conditioning is a paradigm in which an initially neutral stimulus such as a tone (conditioned stimulus, CS), through the pairing with an aversive unconditioned stimulus (US) such as a mild foot-shock, acquires aversive properties and comes to elicit a fear related freezing response. C ...
Leukaemia Section t(11;14)(q24;q32) IGH/miR -125b-1 Atlas of Genetics and Cytogenetics
... leukemic recurrence as bilateral ovarian tumors 7 years after allogenic bone marrow transplantation for BCPALL. Chapiro et al. reported two further adult cases: a female patient aged 45 years with an early-pre-B phenotype who died 21 months after diagnostic, and a male patient aged 33 years who were ...
... leukemic recurrence as bilateral ovarian tumors 7 years after allogenic bone marrow transplantation for BCPALL. Chapiro et al. reported two further adult cases: a female patient aged 45 years with an early-pre-B phenotype who died 21 months after diagnostic, and a male patient aged 33 years who were ...
Original Article Genetic and epigenetic association studies suggest
... breast cancer risk (OR=1.59, 95% CI: 1.06 -2.39), compared to the homozygous common genotype. When stratified by menopausal status, the variant alleles of both rs11544382 (OR=1.82, 95% CI: 1.09-3.03) and rs34324334 (OR=1.76, 95% CI: 1.10-2.83) were significantly associated with breast cancer risk in ...
... breast cancer risk (OR=1.59, 95% CI: 1.06 -2.39), compared to the homozygous common genotype. When stratified by menopausal status, the variant alleles of both rs11544382 (OR=1.82, 95% CI: 1.09-3.03) and rs34324334 (OR=1.76, 95% CI: 1.10-2.83) were significantly associated with breast cancer risk in ...
The making of the Fittest: Natural Selection and Adaptation
... One collecting site was in Arizona. The other three were in New Mexico. Dr. Nachman and colleagues observed no significant differences in the color of the rocks in the four locations sampled. However, the dark-colored mice from the three New Mexico locations were slightly darker than the dark-colore ...
... One collecting site was in Arizona. The other three were in New Mexico. Dr. Nachman and colleagues observed no significant differences in the color of the rocks in the four locations sampled. However, the dark-colored mice from the three New Mexico locations were slightly darker than the dark-colore ...
Stress effects on memory
... of the learned material (Payne et al., 2007) or the interval between the stressful episode and the learning experience (Diamond et al., 2007). Another important factor might be whether the memory is tested immediately after learning when noradrenaline levels peak, slightly later when particularly gl ...
... of the learned material (Payne et al., 2007) or the interval between the stressful episode and the learning experience (Diamond et al., 2007). Another important factor might be whether the memory is tested immediately after learning when noradrenaline levels peak, slightly later when particularly gl ...
Top Ten Ways to Ensure Valid RNAi Data
... One of the best ways to increase confidence in data from siRNA experiments is to independently use two or more siRNAs to a single target gene. Different siRNAs to the same gene with comparable gene silencing efficacy should induce similar changes in gene expression profiles or phenotypes. Any change ...
... One of the best ways to increase confidence in data from siRNA experiments is to independently use two or more siRNAs to a single target gene. Different siRNAs to the same gene with comparable gene silencing efficacy should induce similar changes in gene expression profiles or phenotypes. Any change ...
Effects of adenovirus delivered Flt
... induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of these enzymes is regulated at the transcriptional level and is mediated by a specific enhancer, the antioxidant response element or ARE, found in the promoter of the enzyme's gene. The transcription factor Nr ...
... induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of these enzymes is regulated at the transcriptional level and is mediated by a specific enhancer, the antioxidant response element or ARE, found in the promoter of the enzyme's gene. The transcription factor Nr ...
Recent progress on the Ada response for inducible repair of DNA
... in DNA binding and an ‘arginine finger’ to extrude the O6-alkG nucleotide from the duplex DNA. The extrahelical base can then reach the recessed AGT active site (Daniels and Tainer, 2000). These conserved motifs in the E. coli C-Ada19 domain are shown in Figure 3. A nucleotide flipping mechanism has ...
... in DNA binding and an ‘arginine finger’ to extrude the O6-alkG nucleotide from the duplex DNA. The extrahelical base can then reach the recessed AGT active site (Daniels and Tainer, 2000). These conserved motifs in the E. coli C-Ada19 domain are shown in Figure 3. A nucleotide flipping mechanism has ...