Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish
... changes of four amino acids and a premature termination resulting in the loss of eight amino acids at the Cterminus of cyp19a in the sequence of accession AF004521. The other sequence in GenBank (accession number AF120031) is a partial sequence. It differs from our cyp19b (accession number AF183908) ...
... changes of four amino acids and a premature termination resulting in the loss of eight amino acids at the Cterminus of cyp19a in the sequence of accession AF004521. The other sequence in GenBank (accession number AF120031) is a partial sequence. It differs from our cyp19b (accession number AF183908) ...
Toxicity Mechanisms Identification via Gene Set
... In addition to the time factor, it is recognized that the molecular toxicity response is also dose-dependent.18 Transition of dominant function or pathway at different dose concentrations has been observed in previous studies, which provided extra mechanistic information beyond the traditional phenot ...
... In addition to the time factor, it is recognized that the molecular toxicity response is also dose-dependent.18 Transition of dominant function or pathway at different dose concentrations has been observed in previous studies, which provided extra mechanistic information beyond the traditional phenot ...
The Cognitive Neuroscience of Human Memory Since H.M.
... the dentate gyrus. There was also some cell loss in entorhinal cortex and, for W.H., cell loss in the subiculum, as well. The more severe memory impairment in these two cases, in comparison to R.B. and G.D., could be due to the additional damage within the hippocampus or to the cell loss in entorhin ...
... the dentate gyrus. There was also some cell loss in entorhinal cortex and, for W.H., cell loss in the subiculum, as well. The more severe memory impairment in these two cases, in comparison to R.B. and G.D., could be due to the additional damage within the hippocampus or to the cell loss in entorhin ...
Full Text - American Diabetes Association
... has persisted in the central nervous system (7). Furthermore, despite its migration to the pancreas, the vertebrate b-cell continues to communicate with the central nervous system, and the autonomic nervous system plays a critical role in the regulation of insulin secretion (8,9). Not surprisingly, ...
... has persisted in the central nervous system (7). Furthermore, despite its migration to the pancreas, the vertebrate b-cell continues to communicate with the central nervous system, and the autonomic nervous system plays a critical role in the regulation of insulin secretion (8,9). Not surprisingly, ...
w + gene is silenced in some cells
... • One of the few genes expressed on the inactive X but is not expressed on the active X Xist RNA is a large, non-coding, cis-acting regulatory RNA • Binds to the X-chromosome that it was expressed from ...
... • One of the few genes expressed on the inactive X but is not expressed on the active X Xist RNA is a large, non-coding, cis-acting regulatory RNA • Binds to the X-chromosome that it was expressed from ...
Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO).
... TrEMBL (8–10) and Compugen] in GO development and annotation make this possible. Complete annotation of S.cerevisiae genes to GO will allow users to find all genes, including those across species, which share the same (or related) annotation(s) for function, process and component. GO consists of thr ...
... TrEMBL (8–10) and Compugen] in GO development and annotation make this possible. Complete annotation of S.cerevisiae genes to GO will allow users to find all genes, including those across species, which share the same (or related) annotation(s) for function, process and component. GO consists of thr ...
Virulence gene regulation in Salmonella enterica
... gastroenteritis is much higher (2). Salmonella infection follows ingestion of contaminated food, water or beverages and requires survival in the stomach and colonization of the small intestine. At this stage, the bacteria are seen to start multiplying and adhering to the intestinal mucosa. In the mo ...
... gastroenteritis is much higher (2). Salmonella infection follows ingestion of contaminated food, water or beverages and requires survival in the stomach and colonization of the small intestine. At this stage, the bacteria are seen to start multiplying and adhering to the intestinal mucosa. In the mo ...
Gadd45g Is Essential for Primary Sex Determination, Male
... and cytoplasmic proteins that bind to and modify the activity of other intracellular proteins, including p21 [1,2], PCNA [1,2], CRIF [3], CDK1 [4] and the MAP kinases p38 [5] and MAP3K4 [6]. They are implicated in the regulation of apoptosis, survival, senescence, cell cycle control, DNA repair and ...
... and cytoplasmic proteins that bind to and modify the activity of other intracellular proteins, including p21 [1,2], PCNA [1,2], CRIF [3], CDK1 [4] and the MAP kinases p38 [5] and MAP3K4 [6]. They are implicated in the regulation of apoptosis, survival, senescence, cell cycle control, DNA repair and ...
The Cognitive Neuroscience of Human Memory Since H.M.
... the dentate gyrus. There was also some cell loss in entorhinal cortex and, for W.H., cell loss in the subiculum, as well. The more severe memory impairment in these two cases, in comparison to R.B. and G.D., could be due to the additional damage within the hippocampus or to the cell loss in entorhin ...
... the dentate gyrus. There was also some cell loss in entorhinal cortex and, for W.H., cell loss in the subiculum, as well. The more severe memory impairment in these two cases, in comparison to R.B. and G.D., could be due to the additional damage within the hippocampus or to the cell loss in entorhin ...
To comprehensively identify the range of germline ARMC5
... The aim of this project was to a mouse model of GDM to examine whether resveratrol can prevent the development of GDM. The use of a GDM mouse model (db/+ mouse strain) to test the effects of phytophenols to prevent GDM in vivo, was a new avenue of research in our laboratory. We had 3 groups of mice ...
... The aim of this project was to a mouse model of GDM to examine whether resveratrol can prevent the development of GDM. The use of a GDM mouse model (db/+ mouse strain) to test the effects of phytophenols to prevent GDM in vivo, was a new avenue of research in our laboratory. We had 3 groups of mice ...
Genes can be switched on and off by the protein CTCF
... I injected DNA into mouse embryos, using a special reporting system to see if CTCF was active or not. Dependent upon whether the DNA contained a binding site for CTCF so that CTCF could bind and function, or contained no such binding site, different signals were expected. However, I could not observ ...
... I injected DNA into mouse embryos, using a special reporting system to see if CTCF was active or not. Dependent upon whether the DNA contained a binding site for CTCF so that CTCF could bind and function, or contained no such binding site, different signals were expected. However, I could not observ ...
Two ParaHox genes, SpLox and SpCdx, interact to
... To investigate the function of the SpLox gene in the embryo, genespecific morpholino antisense oligonucleotides (MASO) were injected into fertilized eggs to silence the gene by blocking production of the protein, and the phenotype of the resultant embryos and larvae was analyzed. Control injected la ...
... To investigate the function of the SpLox gene in the embryo, genespecific morpholino antisense oligonucleotides (MASO) were injected into fertilized eggs to silence the gene by blocking production of the protein, and the phenotype of the resultant embryos and larvae was analyzed. Control injected la ...
Genome Biology - Department of Computer Science and
... Many computational methods have also been proposed to predict TFBSs [12-19]. These methods are mostly based on the idea that the binding of a TF is mediated by the recognition of its binding motif represented as a position specific scoring matrix (PSSM). PSSMs are usually discovered as those enrich ...
... Many computational methods have also been proposed to predict TFBSs [12-19]. These methods are mostly based on the idea that the binding of a TF is mediated by the recognition of its binding motif represented as a position specific scoring matrix (PSSM). PSSMs are usually discovered as those enrich ...
DNA Methylation Maintains Allele-specific KIR Gene Expression in
... (9, 10). Indeed, except for the borders and one internal 14kb region, the 150-kb KIR locus does not have a single distinctive stretch of more than 100 bp. Despite high sequence similarity, KIR genes are regulated independently. KIR gene expression differs between NK cell clones in both number and id ...
... (9, 10). Indeed, except for the borders and one internal 14kb region, the 150-kb KIR locus does not have a single distinctive stretch of more than 100 bp. Despite high sequence similarity, KIR genes are regulated independently. KIR gene expression differs between NK cell clones in both number and id ...
Sequences 5` to Translation Start Regulate
... tissue specificity of expression. The extra regions of nucleotide sequence conservation between SSU301 and SSU611 might contribute to the high expression levels of these two genes. Studies that define the c/s-acting elements in 5' promoter regions generally use deletion analysis of the pertinent seq ...
... tissue specificity of expression. The extra regions of nucleotide sequence conservation between SSU301 and SSU611 might contribute to the high expression levels of these two genes. Studies that define the c/s-acting elements in 5' promoter regions generally use deletion analysis of the pertinent seq ...
Gene Regulatory Network of Ikaros in T cell development and
... Ikaros is a master regulator of lymphogenesis, especially critical for lymphoid differentiation and maturation. Recurrent genomic lesions of Ikaros have been found associated with high risks of relapse of leukemia and poor outcome of therapy. However, it remains unclear about the gene regulatory net ...
... Ikaros is a master regulator of lymphogenesis, especially critical for lymphoid differentiation and maturation. Recurrent genomic lesions of Ikaros have been found associated with high risks of relapse of leukemia and poor outcome of therapy. However, it remains unclear about the gene regulatory net ...
Enhanced cholinergic suppression of previously strengthened synapses enables the formation of
... structures. In particular, acetylcholine may regulate the dynamics of encoding and retrieval of information by regulating the magnitude of synaptic transmission at excitatory recurrent connections. Many abstract models of associative memory function ignore the influence of changes in synaptic strengt ...
... structures. In particular, acetylcholine may regulate the dynamics of encoding and retrieval of information by regulating the magnitude of synaptic transmission at excitatory recurrent connections. Many abstract models of associative memory function ignore the influence of changes in synaptic strengt ...
embj201490542-sup-0013
... target genes. To define genes that become induced upon Scl expression, SclhCD4 reporter ES cells (Chung et al, 2002) were used to identify genes that become up-regulated in day 4 Scl-expressing mesoderm (Flk1+Scl+) as compared to Flk1+Scl- mesodermal precursors that give rise to other mesodermal lin ...
... target genes. To define genes that become induced upon Scl expression, SclhCD4 reporter ES cells (Chung et al, 2002) were used to identify genes that become up-regulated in day 4 Scl-expressing mesoderm (Flk1+Scl+) as compared to Flk1+Scl- mesodermal precursors that give rise to other mesodermal lin ...
Relationship between expression amount and codon usage bias
... CAI(codon adaptation index) and ENC(effective number of codons). These data are also calculated from statistic data of the yeast genome on the Internet. The gene families studied were the yeast 2 gene family which have only two genes in a single family, all gene family with 50% or greater similariti ...
... CAI(codon adaptation index) and ENC(effective number of codons). These data are also calculated from statistic data of the yeast genome on the Internet. The gene families studied were the yeast 2 gene family which have only two genes in a single family, all gene family with 50% or greater similariti ...
WHAT IS A GENE? - Electronic Scholarly Publishing
... discovered by Muller 16 the methods available to geneticists for direct studies of gene properties were highly unsatisfactory. High stability of the great majority of genes and inability to produce changes experimentally on any of the known genes made direct approach to the study of the gene a very ...
... discovered by Muller 16 the methods available to geneticists for direct studies of gene properties were highly unsatisfactory. High stability of the great majority of genes and inability to produce changes experimentally on any of the known genes made direct approach to the study of the gene a very ...
Identification of a novel streptococcal gene cassette mediating
... gene expression (4, 25, 37, 67). Remarkably, SOS-induced error-prone DnaE2 polymerase, by its mutagenic activity, contributes to the ability of Mycobacterium tuberculosis to persist and develop antibiotic resistance during infection (9). The genus Streptococcus includes species that are part of the ...
... gene expression (4, 25, 37, 67). Remarkably, SOS-induced error-prone DnaE2 polymerase, by its mutagenic activity, contributes to the ability of Mycobacterium tuberculosis to persist and develop antibiotic resistance during infection (9). The genus Streptococcus includes species that are part of the ...
Minute Sketches - Paul D. Heideman
... A good minute sketch map contains much more information than either a concept map or a mind map. In addition, a minute sketch map can be as fast to create as either a mind map or a concept map. Printing or writing words is often as slow or even slower than these sketches (note that most of the sketc ...
... A good minute sketch map contains much more information than either a concept map or a mind map. In addition, a minute sketch map can be as fast to create as either a mind map or a concept map. Printing or writing words is often as slow or even slower than these sketches (note that most of the sketc ...
Investigation of the role of the Inflammasome triggering HIN200
... At six months, the subcongenic model B10.Yaa.Bxs3.Ifi’s titres of ANA, renal histology, splenic length and weight were similar to the non-autoimmune B10.Yaa. At twelve months in B10.Yaa.Bxs3.Ifi there was significant difference in the levels of ANA titres of antibodies, evidence of nephritis and ele ...
... At six months, the subcongenic model B10.Yaa.Bxs3.Ifi’s titres of ANA, renal histology, splenic length and weight were similar to the non-autoimmune B10.Yaa. At twelve months in B10.Yaa.Bxs3.Ifi there was significant difference in the levels of ANA titres of antibodies, evidence of nephritis and ele ...
Supplementary Text - Austin Publishing Group
... C. elegans, 16 human homolgues are known [34]. Subsequently, knocking down the human orthologs of the C. elegans genes by using shRNA constructs, it was shown that 26 human orthologs of the 186 C. elegans modifier genes had effect on the aggregates of mutant HTT. In addition, it was shown that eukar ...
... C. elegans, 16 human homolgues are known [34]. Subsequently, knocking down the human orthologs of the C. elegans genes by using shRNA constructs, it was shown that 26 human orthologs of the 186 C. elegans modifier genes had effect on the aggregates of mutant HTT. In addition, it was shown that eukar ...
gene transfer - Bio-Rad
... mode of delivery (DNA uptake vs. direct intracellular penetration) and/or quantity of DNA introduced. Dose-dependent non-specific immune responses can be triggered by plasmid DNA prepared from bacteria due to unmethylated DNA sequences.63 Lower Th1 responses are observed in particle-mediated immuniz ...
... mode of delivery (DNA uptake vs. direct intracellular penetration) and/or quantity of DNA introduced. Dose-dependent non-specific immune responses can be triggered by plasmid DNA prepared from bacteria due to unmethylated DNA sequences.63 Lower Th1 responses are observed in particle-mediated immuniz ...