Joshua Krämer Dr. med. Pyruvate Kinase Expression and Activity in
... The two diseases have some common predisposing risk factors, both feature high intracellular glucose levels and possible pro-malignant effects of diabetes-related pathways are subject of current research and discussion. Pyruvate kinase expression and activity in diabetes have previously been studied ...
... The two diseases have some common predisposing risk factors, both feature high intracellular glucose levels and possible pro-malignant effects of diabetes-related pathways are subject of current research and discussion. Pyruvate kinase expression and activity in diabetes have previously been studied ...
Rapid Critical Period Induction by Tonic Inhibition in Visual Cortex
... intracortical inhibition Whereas OD shifts were induced immediately after brief DZ treatment, this plasticity was abolished later, suggesting that DZ triggered irreversible changes of intracortical circuitry to limit the plastic period. To address the cellular basis of this effect, we examined neuro ...
... intracortical inhibition Whereas OD shifts were induced immediately after brief DZ treatment, this plasticity was abolished later, suggesting that DZ triggered irreversible changes of intracortical circuitry to limit the plastic period. To address the cellular basis of this effect, we examined neuro ...
Supplementary Notes for the work: "Evolutionary Rate and Gene
... Supplementary Notes for the work: "Evolutionary Rate and Gene Expression Across Different Brain Regions" ...
... Supplementary Notes for the work: "Evolutionary Rate and Gene Expression Across Different Brain Regions" ...
Gene Regulation Notes
... • General transcription factors are essential for the transcription of all protein-coding genes ...
... • General transcription factors are essential for the transcription of all protein-coding genes ...
Mouse models of obesity
... leads to hyperphagia and increased adiposity,[32] but NPY knockout mice exhibit normal body weight and response to fasting,[33] indicating that NPY is not a necessary part of the hyperphagic fasting response and that NPY may be a redundant signalling molecule in weight regulation. On the other hand, ...
... leads to hyperphagia and increased adiposity,[32] but NPY knockout mice exhibit normal body weight and response to fasting,[33] indicating that NPY is not a necessary part of the hyperphagic fasting response and that NPY may be a redundant signalling molecule in weight regulation. On the other hand, ...
Genes Involved in the Seminoma Testicular Cancer
... difference allows infer changes as a result of treatment, disease or other causes. Because, this task is widely used in fields such as pharmaceuticals, in view of facilitating the development of medicines to the suppression or activation of genes related to various types of cancer. As a result, in t ...
... difference allows infer changes as a result of treatment, disease or other causes. Because, this task is widely used in fields such as pharmaceuticals, in view of facilitating the development of medicines to the suppression or activation of genes related to various types of cancer. As a result, in t ...
Letter Neighboring Genes Show
... pairs showing interchromosomal colocalization show higher similarity in histone modification levels than separated neighboring gene pairs not showing interchromosomal colocalization (P < 0:05, Mann–Whitney U test, fig. 3B). Moreover, separated neighboring gene pairs showing interchromosomal colocali ...
... pairs showing interchromosomal colocalization show higher similarity in histone modification levels than separated neighboring gene pairs not showing interchromosomal colocalization (P < 0:05, Mann–Whitney U test, fig. 3B). Moreover, separated neighboring gene pairs showing interchromosomal colocali ...
The constitution and the control of the ovarian
... Formation of primordial follicles In mice, before establishment of the pool of primordial follicles, following their proliferation and startup of meiosis as described above, nests of oogonia are observed. Then the breakdown of nests leads to massive apoptosis and formation of primordial follicles co ...
... Formation of primordial follicles In mice, before establishment of the pool of primordial follicles, following their proliferation and startup of meiosis as described above, nests of oogonia are observed. Then the breakdown of nests leads to massive apoptosis and formation of primordial follicles co ...
REVIEW ARTICLE Regulation of Expression of the Integrated
... The most striking and illustrative examples of transcriptional control of proviruses derive from those retrovirus genomes which are carried as genetic determinants in the germ lines of many vertebrates. Although several theories have been proposed for the origin of these proviruses, accumulating evi ...
... The most striking and illustrative examples of transcriptional control of proviruses derive from those retrovirus genomes which are carried as genetic determinants in the germ lines of many vertebrates. Although several theories have been proposed for the origin of these proviruses, accumulating evi ...
Relationship Between Serum BDNF Levels and Cognitive Functions
... Key words: depression, BDNF (Brain-derived neurotrophic factor), attention, memory, cortisol Journal of Mood Disorders 2012;2(2):58-65 ...
... Key words: depression, BDNF (Brain-derived neurotrophic factor), attention, memory, cortisol Journal of Mood Disorders 2012;2(2):58-65 ...
Cellular Mechanisms in the Amygdala Involved in Memory
... fear in their minds deeply might fall into fear-related disorders in future. Fear is a conserved emotion in response to danger and triggers some defensive mechanisms for adapting to threatening events for survival. Moreover, fear can lead to a number of anxiety disorders when aberrantly expressed. D ...
... fear in their minds deeply might fall into fear-related disorders in future. Fear is a conserved emotion in response to danger and triggers some defensive mechanisms for adapting to threatening events for survival. Moreover, fear can lead to a number of anxiety disorders when aberrantly expressed. D ...
The β-Globin LCR is Not Necessary for an Open Chromatin
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
Postnatal microbial colonization programs HPA system for stress
... GR, which negatively regulates HPA axis activation by inhibiting hypothalamic CRF gene expression, was significantly lower in the cortex, but not the hypothalamus or hippocampus, of GF mice than in SPF mice (relative values of GR to GAPDH mRNA: cortex, GF 0.94 ± 0.69 versus SPF 1.82 ± 0.62; hypothal ...
... GR, which negatively regulates HPA axis activation by inhibiting hypothalamic CRF gene expression, was significantly lower in the cortex, but not the hypothalamus or hippocampus, of GF mice than in SPF mice (relative values of GR to GAPDH mRNA: cortex, GF 0.94 ± 0.69 versus SPF 1.82 ± 0.62; hypothal ...
FEBS Letters
... In order to identify and analyze the dxs gene from cyanobacteria, analysis of conserved regions in the dxs gene of E. coli [9] and related sequences of hypothetical proteins in Bacillus subtilis and Synechocystis sp. PCC 6803 was performed. This led us to design suitable oligonucleotides (1for, 1rev ...
... In order to identify and analyze the dxs gene from cyanobacteria, analysis of conserved regions in the dxs gene of E. coli [9] and related sequences of hypothetical proteins in Bacillus subtilis and Synechocystis sp. PCC 6803 was performed. This led us to design suitable oligonucleotides (1for, 1rev ...
Free Full Text ( Final Version , 339kb )
... Genes are discovered almost on a daily basis and new names have to be found. Although there are guidelines for gene nomenclature, the naming process is highly creative. Human genes are often named with a gene symbol and a longer, more descriptive term; the short form is very often an abbreviation of ...
... Genes are discovered almost on a daily basis and new names have to be found. Although there are guidelines for gene nomenclature, the naming process is highly creative. Human genes are often named with a gene symbol and a longer, more descriptive term; the short form is very often an abbreviation of ...
Antisense derivatives of U7 small nuclear RNA as
... small size, will fit into all types of gene therapy vectors so that they can be efficiently targeted to many different tissues and cell types. Toxic side effects have not been observed, and the desired antisense effect should only be exerted in those cells expressing the targeted pre-mRNA. Thus, in ...
... small size, will fit into all types of gene therapy vectors so that they can be efficiently targeted to many different tissues and cell types. Toxic side effects have not been observed, and the desired antisense effect should only be exerted in those cells expressing the targeted pre-mRNA. Thus, in ...
Recent Statistical Approaches
... • observe changes in a gene in response to external stimuli (cell samples exposed to hormones, drugs, toxins) • compare gene expressions between different tissue types (tumour vs normal cell samples) To gain understanding of • function of unknown genes • disease process at the molecular level ...
... • observe changes in a gene in response to external stimuli (cell samples exposed to hormones, drugs, toxins) • compare gene expressions between different tissue types (tumour vs normal cell samples) To gain understanding of • function of unknown genes • disease process at the molecular level ...
Chapter 9 From DNA to Protein
... How is RNA Assembled? (cont’d.) • Transcription begins when an RNA polymerase and regulatory proteins attach to a DNA site called a promoter – RNA polymerase moves over a gene region and unwinds the double helix a bit so it can “read” the base sequence of the DNA strand – The polymerase joins free ...
... How is RNA Assembled? (cont’d.) • Transcription begins when an RNA polymerase and regulatory proteins attach to a DNA site called a promoter – RNA polymerase moves over a gene region and unwinds the double helix a bit so it can “read” the base sequence of the DNA strand – The polymerase joins free ...
Imprinted gene detection in Arabidopsis thaliana
... derived tissues contains two alleles that are considered sexless (2 vs. 2m) since these tissues are mature, while the effects of imprinting are mostly confined to early development. The parameters m ≥ 0 and p ≥ 0 reflect the relative mRNA contributions of the maternal and paternal alleles, respectiv ...
... derived tissues contains two alleles that are considered sexless (2 vs. 2m) since these tissues are mature, while the effects of imprinting are mostly confined to early development. The parameters m ≥ 0 and p ≥ 0 reflect the relative mRNA contributions of the maternal and paternal alleles, respectiv ...
Introduction to Adipose Tissue Adipose tissue is not merely an
... acetyltransferase 1 (ACAT1), several phospholipase A (PLA) genes, adiponectin, the gluconeogenic enzyme PEPCK, and glycerol-3-phosphate dehydrogenase (GPD1). PPARγ also functions in macrophage lipid metabolism by inducing the expression of the macrophage scavenger receptor, CD36. The CD36 receptor i ...
... acetyltransferase 1 (ACAT1), several phospholipase A (PLA) genes, adiponectin, the gluconeogenic enzyme PEPCK, and glycerol-3-phosphate dehydrogenase (GPD1). PPARγ also functions in macrophage lipid metabolism by inducing the expression of the macrophage scavenger receptor, CD36. The CD36 receptor i ...
Updated map of duplicated regions in the yeast genome
... pairs that may have been formed by the same genome duplication event, but for which the evidence is weaker. The aim of the present paper is to try to maximize the amount of the yeast genome that is mapped into sister chromosomal regions, working under the assumption that the hypothesis of simultaneo ...
... pairs that may have been formed by the same genome duplication event, but for which the evidence is weaker. The aim of the present paper is to try to maximize the amount of the yeast genome that is mapped into sister chromosomal regions, working under the assumption that the hypothesis of simultaneo ...
Identification of a NodD repressible gene
... of lacZ was assayed by measuring b-galactosidase activity. Firstly, it is clear that the region upstream of px3 has strong nodD-independent promoter activity, because pMP220PX3 confers a high level of activity to strain 8401( pKT230) (Fig. 2). Unlike nod genes such as nodM (Fig. 2), the expression o ...
... of lacZ was assayed by measuring b-galactosidase activity. Firstly, it is clear that the region upstream of px3 has strong nodD-independent promoter activity, because pMP220PX3 confers a high level of activity to strain 8401( pKT230) (Fig. 2). Unlike nod genes such as nodM (Fig. 2), the expression o ...
Varieties of Hairless-Like Mutant Mice
... (l11···~n-·•) mut nuL rnoust· is easil:v distinguished from the otlt~~r type>. of ruutam 1nice by having rhinoccro -like skin. Howt>ver, haJrlt>i! · (hr) and rLino (ltr'') a re allelP..s :.t.nd both hare a common bas.ic upset in the integument . !\JHuy of the mutations aiTecting 'lbe hai r and skin ...
... (l11···~n-·•) mut nuL rnoust· is easil:v distinguished from the otlt~~r type>. of ruutam 1nice by having rhinoccro -like skin. Howt>ver, haJrlt>i! · (hr) and rLino (ltr'') a re allelP..s :.t.nd both hare a common bas.ic upset in the integument . !\JHuy of the mutations aiTecting 'lbe hai r and skin ...
Correlations Between Gene Expression and Gene Conservation in
... (P < 10ⳮ21). Moreover, pombe-specific genes were underrepresented among genes repressed during sexual differentiation, contributing only 5.9% of those genes (P < 10ⳮ7). We defined “pombe-specific genes” as those not shared with the S. cerevisiae and C. elegans genomes. To confirm these results, we u ...
... (P < 10ⳮ21). Moreover, pombe-specific genes were underrepresented among genes repressed during sexual differentiation, contributing only 5.9% of those genes (P < 10ⳮ7). We defined “pombe-specific genes” as those not shared with the S. cerevisiae and C. elegans genomes. To confirm these results, we u ...