The Structure and Function of the DNA from Bacteriophage Lambda
... defined more explicitly later; for the present, consider it as synonymous with the direction of transcription along the DNA. In order to include bacterial genes which are closely linked to prophage lambda within these considerations, the DNA from the lambda dg variant will also be discussed. The rel ...
... defined more explicitly later; for the present, consider it as synonymous with the direction of transcription along the DNA. In order to include bacterial genes which are closely linked to prophage lambda within these considerations, the DNA from the lambda dg variant will also be discussed. The rel ...
The co-repressor hairless has a role in epithelial cell
... et al., 2001a). Although the HR protein lacks sequence identity to proteins of known structure or function, we recently demonstrated that HR functions as a nuclear receptor corepressor (Potter et al., 2001a). Nuclear receptors are transcription factors that regulate specific changes in gene expressi ...
... et al., 2001a). Although the HR protein lacks sequence identity to proteins of known structure or function, we recently demonstrated that HR functions as a nuclear receptor corepressor (Potter et al., 2001a). Nuclear receptors are transcription factors that regulate specific changes in gene expressi ...
Chromatin: A sticky silence
... forty fold lower than at the telomeres, depending on the relative strengths of the silencer and promoter tested. As silencer-binding factors function primarily by targeting Sir1p, Sir3p and Sir4p, one can bypass the need for a silencer to repress a reporter gene by replacing it with a Gal4p-binding ...
... forty fold lower than at the telomeres, depending on the relative strengths of the silencer and promoter tested. As silencer-binding factors function primarily by targeting Sir1p, Sir3p and Sir4p, one can bypass the need for a silencer to repress a reporter gene by replacing it with a Gal4p-binding ...
Memory consolidation, retrograde amnesia, and the temporal lobe
... amnesia with acute or subacute onset, because assessment of the extent of RA is difficult when the onset of amnesia is unknown, as it often is in degenerative disorders and Korsakoffs syndrome. Finally, we included only those cases which have appeared in the past 20 years, with the exception of case ...
... amnesia with acute or subacute onset, because assessment of the extent of RA is difficult when the onset of amnesia is unknown, as it often is in degenerative disorders and Korsakoffs syndrome. Finally, we included only those cases which have appeared in the past 20 years, with the exception of case ...
Boundary elements and nuclear organization
... blocking the spread of heterochromatin has been described for a variety of identified insulator elements (for a list of such elements, see West et al., 2002), suggestive of their role in preserving the separation between heterochromatin and euchromatin. Recently, the heterochromatic repressive chrom ...
... blocking the spread of heterochromatin has been described for a variety of identified insulator elements (for a list of such elements, see West et al., 2002), suggestive of their role in preserving the separation between heterochromatin and euchromatin. Recently, the heterochromatic repressive chrom ...
Number 2 - Laboratory Animal Boards Study Group
... mice with coisogenic embryonic stem cell lines. To maximize the yield of good quality zygotes for the efficient production of transgenic mice, F1 hybrid females and males are commonly used to recover F2 zygotes for microinjection. The most widely used F1 hybrids are C57BL/6 x SJL and C57BL/6 x DBA/2 ...
... mice with coisogenic embryonic stem cell lines. To maximize the yield of good quality zygotes for the efficient production of transgenic mice, F1 hybrid females and males are commonly used to recover F2 zygotes for microinjection. The most widely used F1 hybrids are C57BL/6 x SJL and C57BL/6 x DBA/2 ...
Get PDF - Wiley Online Library
... A 10.4 kb fragment of the GAN gene, including exon 1 and part of the upstream promoter, were subcloned into a pQZ1 cloning vector. The 0.9 kb AcsI-XmaI fragment containing exon 1 and part of the 3¢ promoter was replaced with a Neo cassette. The vector was then digested by NotI and PmaCI. The targeti ...
... A 10.4 kb fragment of the GAN gene, including exon 1 and part of the upstream promoter, were subcloned into a pQZ1 cloning vector. The 0.9 kb AcsI-XmaI fragment containing exon 1 and part of the 3¢ promoter was replaced with a Neo cassette. The vector was then digested by NotI and PmaCI. The targeti ...
Dosage Compensation Mechanisms: Evolution
... other eutherians. Moreover, female X-chromosome inactivation occurs also in marsupial mammals. In marsupials, inactivation is not random but, as also happens in extraembryonic tissues in at least some eutherians (e.g. mouse), it is always the paternal X chromosome that is inactivated. In addition, X ...
... other eutherians. Moreover, female X-chromosome inactivation occurs also in marsupial mammals. In marsupials, inactivation is not random but, as also happens in extraembryonic tissues in at least some eutherians (e.g. mouse), it is always the paternal X chromosome that is inactivated. In addition, X ...
Original Article Female Rat Hippocampal Cell
... of astrocytes increases after CPP in male Wistar rats (Shaabani et al., 2011) and in the present study we showed that this number also increased in female rats. It seems that there is no difference between male and female rats. Many studies have investigated the phenomenon of conditioning with opioi ...
... of astrocytes increases after CPP in male Wistar rats (Shaabani et al., 2011) and in the present study we showed that this number also increased in female rats. It seems that there is no difference between male and female rats. Many studies have investigated the phenomenon of conditioning with opioi ...
russell-silver syndrome
... expressed (turned on) in both the paternally and maternally inherited gene copies. Imprinted genes are different in that they are expressed (turned on) in a parent of origin specific manner. H19 works to suppress or hold back growth. Usually, the maternal copy of H19 is expressed (on) and the patern ...
... expressed (turned on) in both the paternally and maternally inherited gene copies. Imprinted genes are different in that they are expressed (turned on) in a parent of origin specific manner. H19 works to suppress or hold back growth. Usually, the maternal copy of H19 is expressed (on) and the patern ...
Report Distinct Dynamics of HISTONE3 Variants
... five paternal and ten maternal chromosomes. The triploid endosperm nuclei thus display 15 centromeres marked by HTR12 [40]. Surprisingly, the ten centromeres of the maternal chromosomes remained unmarked by paternal HTR12-GFP during the first three syncytial divisions (Figures 3B and 3C). The absenc ...
... five paternal and ten maternal chromosomes. The triploid endosperm nuclei thus display 15 centromeres marked by HTR12 [40]. Surprisingly, the ten centromeres of the maternal chromosomes remained unmarked by paternal HTR12-GFP during the first three syncytial divisions (Figures 3B and 3C). The absenc ...
Age-related naturally occurring depression of
... The occurrence of neurogenesis in the hippocampus suggests its possible role in hippocampal function (Gould et al., 1999b). Shors et al. used a model of neural precursor proliferation depression induced by the cytostatic agent methylazoxymethanol (MAM) to reduce newborn neuron number; MAM-treated ra ...
... The occurrence of neurogenesis in the hippocampus suggests its possible role in hippocampal function (Gould et al., 1999b). Shors et al. used a model of neural precursor proliferation depression induced by the cytostatic agent methylazoxymethanol (MAM) to reduce newborn neuron number; MAM-treated ra ...
Conspiracy of silence among repeated transgenes
... comparable impact in agriculture and medicine. Researchers usually assume that an integrated transgene’s behavior reflects normal influences at the site of insertion. However, genomes have mechanisms for recognizing potentially threatening sequence elements, like transposons, and silencing them. Cyt ...
... comparable impact in agriculture and medicine. Researchers usually assume that an integrated transgene’s behavior reflects normal influences at the site of insertion. However, genomes have mechanisms for recognizing potentially threatening sequence elements, like transposons, and silencing them. Cyt ...
2007-10_GO-resources_jblake
... The first column is the gene or gene product symbol and name; clicking on the name will take you to the AmiGO gene product detail page, which shows the information held in the GO database about that gene product, including all its GO annotations and the peptide sequence (if available). By clicking ...
... The first column is the gene or gene product symbol and name; clicking on the name will take you to the AmiGO gene product detail page, which shows the information held in the GO database about that gene product, including all its GO annotations and the peptide sequence (if available). By clicking ...
Genomic approaches for the understanding of aging
... Sang-Kyu Park* Department of Medical Biotechnology, College of Medical Science, Soonchunhyang University, Asan 336-745, Korea ...
... Sang-Kyu Park* Department of Medical Biotechnology, College of Medical Science, Soonchunhyang University, Asan 336-745, Korea ...
A Novel CpG Island Set Identifies Tissue-Specific
... human genome, which accords with the adjusted CGI library estimate of 25,200. The coincidence of these numbers masks significant differences, however, as 23% of CGIs in the library are not detected by the NCBI-strict algorithm (4,082 out of 17,387; Table 1). Four randomly selected examples of library ...
... human genome, which accords with the adjusted CGI library estimate of 25,200. The coincidence of these numbers masks significant differences, however, as 23% of CGIs in the library are not detected by the NCBI-strict algorithm (4,082 out of 17,387; Table 1). Four randomly selected examples of library ...
Assembly of additional heterochromatin distinct from centromere
... contains 70 kb of type-I alphoid (␣21-I) array, inverted human telomeric repeats placed at both ends of the molecule by I-SceI digestion, a bsr gene driven by the SV40 early promoter (including the enhancer element) on the right side of the alphoid array and a loxP sequence on the left side (Fig. 1A ...
... contains 70 kb of type-I alphoid (␣21-I) array, inverted human telomeric repeats placed at both ends of the molecule by I-SceI digestion, a bsr gene driven by the SV40 early promoter (including the enhancer element) on the right side of the alphoid array and a loxP sequence on the left side (Fig. 1A ...
A Noise Trimming and Positional Significance of
... where f ( X ) is a mapping function and means "maps to". For an individual gene, we have f ( xi ) ti , where xi is the mutation feature value of the ith gene and ti is the mutation status value of the ith gene. In addition to estimating such a mapping function, the challenge is the data complexi ...
... where f ( X ) is a mapping function and means "maps to". For an individual gene, we have f ( xi ) ti , where xi is the mutation feature value of the ith gene and ti is the mutation status value of the ith gene. In addition to estimating such a mapping function, the challenge is the data complexi ...
Combined expression patterns of QTL
... Relative gene expression values of candidate genes were normalized to actin-79B expression using the comparative method (Livak and Schmittgen, 2001). Four different samples from each line or treatment were analyzed with qRT-PCR and results are presented as relative mean expression levels SE. Variat ...
... Relative gene expression values of candidate genes were normalized to actin-79B expression using the comparative method (Livak and Schmittgen, 2001). Four different samples from each line or treatment were analyzed with qRT-PCR and results are presented as relative mean expression levels SE. Variat ...
Title: Genes in the Postgenomic Era Authors: Paul E. Griffiths and
... over during meiosis - is a process that recombines whole genes. However, if recombination can occur within a gene, so that part of the gene on one chromosome comes to be united with part of the same gene from the other homologous chromosome, then it is possible for the cis-trans test to fail. Intrag ...
... over during meiosis - is a process that recombines whole genes. However, if recombination can occur within a gene, so that part of the gene on one chromosome comes to be united with part of the same gene from the other homologous chromosome, then it is possible for the cis-trans test to fail. Intrag ...
The causes and molecular consequences of polyploidy
... paternally expressed gene ADMETOS.31 This study involved a mutant screen in a JASON mutant background, which produces unreduced gametes at a high frequency, but 30% of the triploid seeds produced are aborted. The ADMETOS-1 JASON double mutant, on the other hand, has only 2% aborted triploid seeds. T ...
... paternally expressed gene ADMETOS.31 This study involved a mutant screen in a JASON mutant background, which produces unreduced gametes at a high frequency, but 30% of the triploid seeds produced are aborted. The ADMETOS-1 JASON double mutant, on the other hand, has only 2% aborted triploid seeds. T ...
Fkh5-deficient mice show dysgenesis in the caudal midbrain and
... the inferior colliculi, are reduced near the midline and partially covered by the anterior cerebellum, whereas their lateral parts are normal in size and shape compared to the wild-type brain (Fig. 5A,C). Interestingly, the brains of Fkh5+/− mice show an intermediate phenotype (Fig. 5B), arguing for ...
... the inferior colliculi, are reduced near the midline and partially covered by the anterior cerebellum, whereas their lateral parts are normal in size and shape compared to the wild-type brain (Fig. 5A,C). Interestingly, the brains of Fkh5+/− mice show an intermediate phenotype (Fig. 5B), arguing for ...
Ribosome stalls at trp codons, allowing 2+3 pairing Transcription
... activates CAP. Active CAP binds to the promoter to increase RNA polymerase binding. RNA polymerase transcribes Lac Z, Y and A at HIGH frequency. ...
... activates CAP. Active CAP binds to the promoter to increase RNA polymerase binding. RNA polymerase transcribes Lac Z, Y and A at HIGH frequency. ...
Osteoclasts
... osteoclastogenesis was reported (9). Osteoclastogenesis is tightly regulated by various transcriptional factors, which play pivotal roles by reorganizing gene networks (10). Recently, epigenetic regulations, such as histone modifications and chromatin remodeling, have been revealed as essential for ...
... osteoclastogenesis was reported (9). Osteoclastogenesis is tightly regulated by various transcriptional factors, which play pivotal roles by reorganizing gene networks (10). Recently, epigenetic regulations, such as histone modifications and chromatin remodeling, have been revealed as essential for ...
Commentaries on Viewpoint: Epigenetic regulation of the ACE gene
... enzyme (ACE) might play an important role (4). However, the relationship between ACE genetic variants and endurance is variable (1), and the underlying molecular mechanisms are still poorly understood (5). In this issue of Journal of Applied Physiology, Stuart M. Raleigh (5) proposes that THE epigen ...
... enzyme (ACE) might play an important role (4). However, the relationship between ACE genetic variants and endurance is variable (1), and the underlying molecular mechanisms are still poorly understood (5). In this issue of Journal of Applied Physiology, Stuart M. Raleigh (5) proposes that THE epigen ...