Tracking the Emergence of Conceptual Knowledge during Human
... Activations are shown on the averaged structural MRI scan of the 25 participants, with the color bar indicating the t statistic associated with each voxel and the z score equivalent. Activations in vMPFC and PCC are shown in sagittal ...
... Activations are shown on the averaged structural MRI scan of the 25 participants, with the color bar indicating the t statistic associated with each voxel and the z score equivalent. Activations in vMPFC and PCC are shown in sagittal ...
Nucleotide Polymorphisms in the 2 Gene Define
... different levels of a2b1 revealed two linked nucleotide polymorphisms, separated by almost seventy nucleotides, at bp 807 and 873 in the a2 coding region. These were the only two nucleotide polymorphisms identified within the ,3.5-kb a2 coding region that consistently varied among the samples studie ...
... different levels of a2b1 revealed two linked nucleotide polymorphisms, separated by almost seventy nucleotides, at bp 807 and 873 in the a2 coding region. These were the only two nucleotide polymorphisms identified within the ,3.5-kb a2 coding region that consistently varied among the samples studie ...
One of the crucial proteins to influence type 2 diabetes
... will help determine whether the IVS5-13insC shows a consistent association with type 2 diabetes. However, the direct mechanism by which this variant affects mRNA expression or amino acid sequence remains unclear. As we have shown above, HMGA1 mainly act as an architectural transcription factor invol ...
... will help determine whether the IVS5-13insC shows a consistent association with type 2 diabetes. However, the direct mechanism by which this variant affects mRNA expression or amino acid sequence remains unclear. As we have shown above, HMGA1 mainly act as an architectural transcription factor invol ...
Mutations in the gene encoding methyl-CpG-binding
... a 2-fold reduction [37]. Moreover, because of XCI, each cell has either the wild-type or the mutant MECP2active. This excludes a possible dominant-negative mechanism in which the protein produced from the mutant allele would interfere with the function of its wild-type counterpart. However, it does ...
... a 2-fold reduction [37]. Moreover, because of XCI, each cell has either the wild-type or the mutant MECP2active. This excludes a possible dominant-negative mechanism in which the protein produced from the mutant allele would interfere with the function of its wild-type counterpart. However, it does ...
A novel environment-sensitive biodegradable polydisulfide with
... was comparable to or slightly lower than that of corresponding PEI complexes. Moreover, the polydisulfide showed better serum-friendly feature than PEI when delivering either DNA or siRNA in the presence of 10% FBS. This novel polydisulfide is a promising lead for further design and development of s ...
... was comparable to or slightly lower than that of corresponding PEI complexes. Moreover, the polydisulfide showed better serum-friendly feature than PEI when delivering either DNA or siRNA in the presence of 10% FBS. This novel polydisulfide is a promising lead for further design and development of s ...
The contribution of sleep to hippocampus
... preferentially, but not exclusively, consolidation of memory aspects not directly mediated by hippocampal function (procedural, emotional enhancement). Considering the strong evidence for post-learning changes in spindles and non-REM sleep stage 2, this sleep stage probably acts per se or cooperativ ...
... preferentially, but not exclusively, consolidation of memory aspects not directly mediated by hippocampal function (procedural, emotional enhancement). Considering the strong evidence for post-learning changes in spindles and non-REM sleep stage 2, this sleep stage probably acts per se or cooperativ ...
H4K20me1 Contributes to Downregulation of X
... The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits fo ...
... The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits fo ...
Spatially ordered transcription of regulatory DNA in
... To see if the iab region controls the expression of AbdB we have looked at the distribution of Abd-B transcripts in the mutation iab-7MX2. This mutation is an inversion with a breakpoint at about +140 that separates the iab-3-iab-7 region from the Abd-B transcription unit (Fig. 5A) (Karch et al. 198 ...
... To see if the iab region controls the expression of AbdB we have looked at the distribution of Abd-B transcripts in the mutation iab-7MX2. This mutation is an inversion with a breakpoint at about +140 that separates the iab-3-iab-7 region from the Abd-B transcription unit (Fig. 5A) (Karch et al. 198 ...
Differential expression of sex-linked and autosomal germ
... We have examined expression during spermatogenesis in the mouse of three Y-linked genes, 11 X-linked genes and 22 autosomal genes, all previously shown to be germ-cell-specific and expressed in premeiotic spermatogonia, plus another 21 germ-cell-specific autosomal genes that initiate expression in m ...
... We have examined expression during spermatogenesis in the mouse of three Y-linked genes, 11 X-linked genes and 22 autosomal genes, all previously shown to be germ-cell-specific and expressed in premeiotic spermatogonia, plus another 21 germ-cell-specific autosomal genes that initiate expression in m ...
Imprinting and Seed Development
... phenotype as one of growth inhibition might not be entirely straightforward. Other theories have been proposed to explain imprinting. These include imprinting as a defense against chromosome loss or gain or as a means to accurately control gene expression (Hurst, 1997). Or, imprinting could be a by- ...
... phenotype as one of growth inhibition might not be entirely straightforward. Other theories have been proposed to explain imprinting. These include imprinting as a defense against chromosome loss or gain or as a means to accurately control gene expression (Hurst, 1997). Or, imprinting could be a by- ...
A Classification of Microarray Gene Expression Data Using
... robust system for the identification of stomach cancer using Artificial Neural Network (ANN) and Discrete Cosine Transform (DCT). In this proposed system, the DCT has been used to extract the classification features from the stomach microarrays. Subsequently, the features extracted from the DCT coef ...
... robust system for the identification of stomach cancer using Artificial Neural Network (ANN) and Discrete Cosine Transform (DCT). In this proposed system, the DCT has been used to extract the classification features from the stomach microarrays. Subsequently, the features extracted from the DCT coef ...
FEMS Microbiology Letters
... coenzyme A to acetyl phosphate, is activated by the addition of excess glucose or fructose, and that this activation is dependent on CcpA [16,17]. As the expression of pta depends on the presence of glucose in the medium, it is possible that expression of srfA observed in DSM-G may be due to inducti ...
... coenzyme A to acetyl phosphate, is activated by the addition of excess glucose or fructose, and that this activation is dependent on CcpA [16,17]. As the expression of pta depends on the presence of glucose in the medium, it is possible that expression of srfA observed in DSM-G may be due to inducti ...
Pierre MADL Div. of Material Sciences Dep
... i) processes involved in the genetic development of an organism, especially the activation and deactivation of genes …. i) heritable changes in gene function that occur without a change in the DNA sequence …. i) a factor that changes the phenotype without changing the genotype …. i) the study of inh ...
... i) processes involved in the genetic development of an organism, especially the activation and deactivation of genes …. i) heritable changes in gene function that occur without a change in the DNA sequence …. i) a factor that changes the phenotype without changing the genotype …. i) the study of inh ...
Mechanisms of Nucleolar Dominance in Animals and Plants
... among others, had shown that such secondary constrictions are the site at which the nucleolus forms during interphase and that constrictions only form when nucleoli are present. McClintock (33) reviewed Navashin's data and predicted that the nucleolus organizers of various Crepis species could be ra ...
... among others, had shown that such secondary constrictions are the site at which the nucleolus forms during interphase and that constrictions only form when nucleoli are present. McClintock (33) reviewed Navashin's data and predicted that the nucleolus organizers of various Crepis species could be ra ...
Morphology of nuclear transcription | SpringerLink
... or from separate CTs. In the latter case, they can form long-range loops as often observed in coregulated loci during cell differentiation processes (Park et al. 2014). This spatial organization is understood to be pivotal for transcription linking chromatin architecture to coordinated gene expressi ...
... or from separate CTs. In the latter case, they can form long-range loops as often observed in coregulated loci during cell differentiation processes (Park et al. 2014). This spatial organization is understood to be pivotal for transcription linking chromatin architecture to coordinated gene expressi ...
The Process of How COMT Genetic Variants Provide the
... The COMT enzyme can degrade dopamine before it travels across a synaptic gap to activate another nerve. The enzyme changes the chemical structure of dopamine so that it no longer fits in a nerve receptor. The COMT enzyme built from the Warrior allele is more actively involved in the degradation of D ...
... The COMT enzyme can degrade dopamine before it travels across a synaptic gap to activate another nerve. The enzyme changes the chemical structure of dopamine so that it no longer fits in a nerve receptor. The COMT enzyme built from the Warrior allele is more actively involved in the degradation of D ...
Modeling goal-directed spatial navigation in the rat based on physiological
... hypothesized that intrinsic mechanisms may maintain firing patterns, as initially proposed by Lisman (Lisman & Idiart, 1995). One such mechanism is ADP (calcium sensitive cation currents induced by muscarinic receptor activation (Klink & Alonso, 1997)), as shown below. Synchronized timing can be ach ...
... hypothesized that intrinsic mechanisms may maintain firing patterns, as initially proposed by Lisman (Lisman & Idiart, 1995). One such mechanism is ADP (calcium sensitive cation currents induced by muscarinic receptor activation (Klink & Alonso, 1997)), as shown below. Synchronized timing can be ach ...
Lluís Millán Ariño GENOMIC DISTRIBUTION AND FUNCTIONAL SPECIFICITY OF
... 3.1. All H1 variants are non-specifically present at gene promoters and are depleted from transcription start sites (TSS) in active genes In our first attempt to elucidate H1 variant distribution in the genome, we tested occupancy in specific loci corresponding to diverse genomic features. Therefore ...
... 3.1. All H1 variants are non-specifically present at gene promoters and are depleted from transcription start sites (TSS) in active genes In our first attempt to elucidate H1 variant distribution in the genome, we tested occupancy in specific loci corresponding to diverse genomic features. Therefore ...
The genetic basis of adaptive melanism in
... uniformly light. Of the 29 mice from the Pinacate site, 16 of 18 mice (89%) caught on the dark lava were dark, whereas 10 of 11 mice (91%) caught on the light-colored rocks were light (Fig. 1B). Similarly, of the 20 mice from Armendaris, 7 of 8 mice (88%) caught on the dark lava were dark, whereas a ...
... uniformly light. Of the 29 mice from the Pinacate site, 16 of 18 mice (89%) caught on the dark lava were dark, whereas 10 of 11 mice (91%) caught on the light-colored rocks were light (Fig. 1B). Similarly, of the 20 mice from Armendaris, 7 of 8 mice (88%) caught on the dark lava were dark, whereas a ...
A Stress-Induced Shift From Trace to Delay Conditioning Depends
... (Figure 2), another CS1 that was followed by the US after an interval of 3 seconds (CS1trace), and a third stimulus that was never reinforced (conditioned stimulus not paired with the US, CS-) (27). Three gray-scaled pictures of neutral male faces served as CS (28,29), and the assignment to CS type ...
... (Figure 2), another CS1 that was followed by the US after an interval of 3 seconds (CS1trace), and a third stimulus that was never reinforced (conditioned stimulus not paired with the US, CS-) (27). Three gray-scaled pictures of neutral male faces served as CS (28,29), and the assignment to CS type ...
Plasticity, memory and the adaptive landscape of the genotype
... plasticity (P), and the mean (x). Genetic assimilation occurs much closer to the peak if an epigenetic inheritance system is present (equation (8)). One experiment (Ho et al. 1983) showed that the assimilation of the Bithorax phenocopy can also occur in inbred lines of Drosophila. It was suggested t ...
... plasticity (P), and the mean (x). Genetic assimilation occurs much closer to the peak if an epigenetic inheritance system is present (equation (8)). One experiment (Ho et al. 1983) showed that the assimilation of the Bithorax phenocopy can also occur in inbred lines of Drosophila. It was suggested t ...
Applied and Environmental Microbiology
... and L. marthii (4, 7, 17). Of these only, L. monocytogenes (15) and L. ivanovii (1, 18) are considered as pathogens. The pathogenicity is closely associated with a virulence gene cluster, although other genes like those coding for internalines are implicated in pathogenesis too (16). Like L. monocyt ...
... and L. marthii (4, 7, 17). Of these only, L. monocytogenes (15) and L. ivanovii (1, 18) are considered as pathogens. The pathogenicity is closely associated with a virulence gene cluster, although other genes like those coding for internalines are implicated in pathogenesis too (16). Like L. monocyt ...
in plant physiology
... group of tRNA genes, but not photosynthesis genes (Kanamaru et al., 2001), while SIG6 is essential for the transcription of a wide range of photosynthesis-related genes at an early stage of chloroplast development (Ishizaki et al., 2005). It seems likely that SIG2 and SIG6 work in cooperation durin ...
... group of tRNA genes, but not photosynthesis genes (Kanamaru et al., 2001), while SIG6 is essential for the transcription of a wide range of photosynthesis-related genes at an early stage of chloroplast development (Ishizaki et al., 2005). It seems likely that SIG2 and SIG6 work in cooperation durin ...
TAN Huarong
... fold higher than that of wild-type strain. The sanJ gene was inactivated by the insertion of kanamycin resistance gene and the resulting disruption mutants failed to produce nikkomycins. Moreover, the nikkomycin production was recovered by cis-complementation with a single copy of sanJ. The result i ...
... fold higher than that of wild-type strain. The sanJ gene was inactivated by the insertion of kanamycin resistance gene and the resulting disruption mutants failed to produce nikkomycins. Moreover, the nikkomycin production was recovered by cis-complementation with a single copy of sanJ. The result i ...
The Structure and Function of the DNA from Bacteriophage Lambda
... defined more explicitly later; for the present, consider it as synonymous with the direction of transcription along the DNA. In order to include bacterial genes which are closely linked to prophage lambda within these considerations, the DNA from the lambda dg variant will also be discussed. The rel ...
... defined more explicitly later; for the present, consider it as synonymous with the direction of transcription along the DNA. In order to include bacterial genes which are closely linked to prophage lambda within these considerations, the DNA from the lambda dg variant will also be discussed. The rel ...