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Chapter 5 Gases - Saint Demetrios Astoria School
Chapter 5 Gases - Saint Demetrios Astoria School

... which individuals identically heterozygous for one gene are crossed • Frequency of traits among offspring offers information about the dominance relationship between the alleles ...
Thyroid Hormone and Adipocyte Differentiation
Thyroid Hormone and Adipocyte Differentiation

... FAS, aP2, Glut4, ACC, and the b- adrenergic receptors, among many others. Later markers of differentiation are leptin, adipsin, PEPCK, the a-2 adrenergic receptors, and others (21). Recently, studies using genomic techniques (microarrays) (51) have shown that the cellular programs associated with ad ...
Peer-reviewed Article PDF
Peer-reviewed Article PDF

... gene is on chromosome 12 and presumably on the distal part of 12q [13]. By in situ hybridization, the assignment of the PAH gene was narrowed to chromosome 12q22-q24.1 [14]. Most PAH missense mutations impair enzyme activity by causing increased protein instability and aggregation. An alternative me ...
From spike frequency to free recall:
From spike frequency to free recall:

... Appropriate encoding dynamics require strong afferent input from entorhinal cortex. At the same time, the internal connections of the hippocampus (including both recurrent connections in region CA3 and the Schaffer collaterals from CA3 to CA1) would undergo strong synaptic modification, but weak syn ...
Transcriptional profiling of wheat caryopsis development using
Transcriptional profiling of wheat caryopsis development using

... identified to be differentially expressed at the 6 different time-points examined, which covers the developmental stages from coenocytic endosperm to physiological maturity. Comparison of genes differentially expressed between two time-points revealed a dynamic transcript accumulation profile with m ...
Key transcriptional regulators of the vasoprotective effects of shear
Key transcriptional regulators of the vasoprotective effects of shear

... Another mechanism by which KLF2 confers its anti-inflammatory actions is through inhibition of nuclear localization of phosphorylated ATF2, which is essential for inflammatory gene expression in endothelial cells (6). ATF2 can form a transcriptional complex together with c-Jun, called AP-1 and c-Jun ...
Identification of a Class of Chromatin Boundary Elements
Identification of a Class of Chromatin Boundary Elements

... DNA was amplified by LM-PCR. We used 32B since its footprints on scs9 are virtually identical to those of affinity-purified BEAF (14) and we wished to ensure the absence of any contaminating Drosophila DNA binding factors. The cycle of binding, immunoprecipitation, and amplification was repeated sev ...
reviews - Department of Genetics
reviews - Department of Genetics

... expression of traits seems to be the exception in humans and experimental species such as laboratory mice. Among the several causes of variable phenotypes for Mendelian traits are alternative alleles, environmental factors and modifier genes. Examples of allelic and environmental variability are num ...
Regulation of 6sg expression site transcription and switching in
Regulation of 6sg expression site transcription and switching in

... rRNA spacers are generally inactive, or have low activity, in bloodstream and procyclic forms. Some mechanism apparently operates to ensure full activation of a single ES in bloodstream-form trypanosomes and the inactivity of all ES promoters in procyclic forms. As previously shown, a rRNA promoter ...
Altered cellular proliferation and mesoderm
Altered cellular proliferation and mesoderm

... endogenous lymphocytes and reconstituted in hanging drops with 1×105 foetal liver cell suspensions from 12.5 d.p.c. M33+/+, M33+/− and M33−/− mice. These samples contained equivalent numbers of T cell precursors as determined by serial titration. Unbound cells were removed by washing the lobes trans ...
Identification of Quantitative Trait Loci That Affect Aggressive
Identification of Quantitative Trait Loci That Affect Aggressive

... Despite the complexity of these behaviors, there is accumulating evidence from twin studies that genetic factors play a role, together with environment, in predisposing humans toward aggression (Rushton et al., 1986; Tellegen et al., 1988; Coccaro et al., 1993; Coccaro et al., 1997; Eley et al., 199 ...
Inheritance of Color And The Polled Trait
Inheritance of Color And The Polled Trait

... genes. Very complex genes are responsible for a trait like weaning weight, (Environmental factors like nutrition must also be taken into account) but the polled trait depends on just one gene, expressed by the symbol “P”. The opposite condition, the presence of horns, is expressed as the “p” gene. T ...
The chromatin remodelling factor Brg1 interacts with catenin to
The chromatin remodelling factor Brg1 interacts with catenin to

... b-catenin and wild-type Brg-1 on the activity of a Tcfresponsive reporter plasmid containing the Siamois promoter (Brannon et al., 1997), in the Brg-1/Brm-de®cient cell line SW13. Expression of S33Yb-catenin alone resulted in an ~2- to 3-fold increase in reporter gene activity (Figure 3A). Signi®can ...
MicroRNA: A novel class of master regulators of gene expression
MicroRNA: A novel class of master regulators of gene expression

... MicroRNAs silence gene expression by binding to target sites in the target mRNA, usually within the 3’ UTR. This interaction attenuates protein production by preventing active translation of the messenger or by destabilizing the mRNA. Since most target sites on the mRNA have only partial base comple ...
Effects of turmeric (Curcuma longa) on the expression
Effects of turmeric (Curcuma longa) on the expression

... d and stated that turmeric might have some positive effects on liver enzymes that directly or indirectly reflect a healthier liver. The above findings demonstrate the possible mode of action of TMP as an antioxidant. SOD. Superoxide dismutase catalyzes the conversion of superoxide anions to hydrogen ...
Animal Behaviour SPECIAL ISSUE: KIN SELECTION
Animal Behaviour SPECIAL ISSUE: KIN SELECTION

... show dynamic expression in correlation with variation in behaviour. Behaviour-specific gene expression could occur as a result of transient environmental change, epigenetic changes, and/or changes at the DNA sequence level. These data can be used to study proximate genetic and genomic mechanisms at d ...
The making of the Fittest: Natural Selection and Adaptation
The making of the Fittest: Natural Selection and Adaptation

... • It seems that dark coloration lends some selective advantage even on a light-colored substrate. Ask your students if they can come up with a good explanation. Researchers think it is because rocks and shrubs cast shadows, and the dark-colored mice are pretty well hidden unless they run across the ...
Acceleration of visually cued conditioned fear through the
Acceleration of visually cued conditioned fear through the

... repeated-measures ANOVA showed a significant effect of lesion type (F = 4.5, P < 0.05), time (habituation versus cue; F = 81.0, P < 0.001) and session (F = 6.5, P < 0.01). There were also significant interactions between lesion type and time (F = 25.2, P < 0.01), lesion type, cue type and session (F ...
Recombineering Hunchback identifies two conserved domains
Recombineering Hunchback identifies two conserved domains

... nervous system (Cepko, 1999; Doe and Skeath, 1996; Rapaport et al., 2001; Walsh and Reid, 1995). However, as progenitors change over time to accommodate the production of different tissues, they also undergo a progressive restriction and lose their competence to produce the full assortment of cell t ...
Amygdala-Prefrontal Synchronization Underlies Resistance to
Amygdala-Prefrontal Synchronization Underlies Resistance to

... (A) Experimental design: there were two types of sessions (intermingled across the recording period), either continuous reinforcement (ConS) or partial reinforcement (ParS) schedule. Both schedules reach behavioral plateau within a few trials and maintain it for over 25 trials, resulting in a contro ...
PDF
PDF

... Fig.2.The minimal inferred complexity of Hox gene clusters in the lineage leading to the insects. Panels on the right summarise the diversity of Hox genes described from insects, Crustacea, annelids (Class Hirudinea, leeches) and chordates(Amphioxus, and several vertebrates; a single 'complete' chor ...
Guidelines for Gene Expression Patterns papers
Guidelines for Gene Expression Patterns papers

... (1) Is this manuscript appropriate for MOD or for Gene Expression Patterns (GEP)? Does the ms. contain cloning and/or gene expression data? ...
Proportionality between variances in gene expression induced by
Proportionality between variances in gene expression induced by

... genetic and epigenetic origins? If a phenotype is changeable easily epigenetically through development or environment, is it also more feasible to change genetically? Similarly, if a phenotype is robust to developmental perturbations, is it also robust to genetic variations through evolution? When w ...
Genetic Diversity of Principal Neurons in the Hippocampus
Genetic Diversity of Principal Neurons in the Hippocampus

... produced stable expression patterns restricted to subgroups of neurons in the adult10. In „sparse“ Thy1 lines, high-level transgene expression in few neurons within several neuronal populations has been widely exploited to trace and image neuronal processes and their synaptic connections at high res ...
MiRNA_GO_Meeting_August2015
MiRNA_GO_Meeting_August2015

... When annotating a miRNA we should minimally aim to capture the following: 1. The miRNA’s main role in gene silencing and its target(s); gene silencing by miRNA negative regulation of gene expression mRNA binding involved in post-transcriptional gene silencing by miRNA target mRNA indicated in the an ...
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Epigenetics in learning and memory

While the cellular and molecular mechanisms of learning and memory have long been a central focus of neuroscience, it is only in recent years that attention has turned to the epigenetic mechanisms behind the dynamic changes in gene transcription responsible for memory formation and maintenance. Epigenetic gene regulation often involves the physical marking (chemical modification) of DNA or associated proteins to cause or allow long-lasting changes in gene activity. Epigenetic mechanisms such as DNA methylation and histone modifications (methylation, acetylation, and deacetylation) have been shown to play an important role in learning and memory.
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