Elucidating the Role of Gonadal Hormones in Sexually
... In the liver, metabolism of steroid hormones and drugs has been shown to be sexually differentiated, mainly due to gonadal hormones causing differences in GH. Studies have indicated that sex differences in hepatic steroid metabolism may support a pregnant state when the liver is exposed to high cont ...
... In the liver, metabolism of steroid hormones and drugs has been shown to be sexually differentiated, mainly due to gonadal hormones causing differences in GH. Studies have indicated that sex differences in hepatic steroid metabolism may support a pregnant state when the liver is exposed to high cont ...
Cutting Edge: DNA Polymerases and Are Dispensable for Ig Gene
... IgM with concomitant increase in IgD appears unaffected. Representative cases are shown in Fig. 5. We are currently investigating what type of lymphoid-specific DNA transaction involving pol could generate such a B cell deficit, with these rather surprising individual variations. It has been sugge ...
... IgM with concomitant increase in IgD appears unaffected. Representative cases are shown in Fig. 5. We are currently investigating what type of lymphoid-specific DNA transaction involving pol could generate such a B cell deficit, with these rather surprising individual variations. It has been sugge ...
The genetic basis of adaptation: lessons from concealing coloration
... phenotype in C. intermedius from lava flows; we found unbanded, uniformly melanic hairs in all dark C. intermedius, and banded dorsal hairs in all light C. intermedius (Figure 2), suggesting a possible role for either agouti or Mc1r. A candidate-gene approach has both advantages and limitations. One ...
... phenotype in C. intermedius from lava flows; we found unbanded, uniformly melanic hairs in all dark C. intermedius, and banded dorsal hairs in all light C. intermedius (Figure 2), suggesting a possible role for either agouti or Mc1r. A candidate-gene approach has both advantages and limitations. One ...
Expression of p53 Target Genes in the Early Phase of Long
... regeneration [7, 8]. The activation of caspases, which is regulated by Bcl2 family proteins, seems to be necessary for synaptic modifications during long-term depression [9] and to contribute to LTP [10]. Another p53 transcriptional target, microRNA-34a, also regulates neurite outgrowth, spinal morp ...
... regeneration [7, 8]. The activation of caspases, which is regulated by Bcl2 family proteins, seems to be necessary for synaptic modifications during long-term depression [9] and to contribute to LTP [10]. Another p53 transcriptional target, microRNA-34a, also regulates neurite outgrowth, spinal morp ...
The gene schmalspur functions in mesoderm formation in zebrafish
... *Address correspondence to: Concepción Rojo. Dpto. Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, UCM, 28040 Madrid, Spain. ...
... *Address correspondence to: Concepción Rojo. Dpto. Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, UCM, 28040 Madrid, Spain. ...
Gene methylation in gastric cancer
... by methylating newly synthesized strands of DNA during DNA replication, whereas DNMT3a and DNMT3b are mainly involved in de novo methylation [20]. In general, increased methylation in the promoter region of a gene leads to reduced gene expression, whereas methylation in the transcribed region has a ...
... by methylating newly synthesized strands of DNA during DNA replication, whereas DNMT3a and DNMT3b are mainly involved in de novo methylation [20]. In general, increased methylation in the promoter region of a gene leads to reduced gene expression, whereas methylation in the transcribed region has a ...
Genetics of CO2 fixation in the chemoautotroph Alcaligenes eutrophus
... several autotrophic bacteria have been initiated in recent years [1]. They are focussing on those photolithotrophs and chemolithotrophs using the reductive pentose phosphate cycle (Calvin cycle) as carbon assimilation pathway. Because of the complexity of this cycle--it comprises thirteen reactions ...
... several autotrophic bacteria have been initiated in recent years [1]. They are focussing on those photolithotrophs and chemolithotrophs using the reductive pentose phosphate cycle (Calvin cycle) as carbon assimilation pathway. Because of the complexity of this cycle--it comprises thirteen reactions ...
Identification of Genetic and Epigenetic Risk Factors for Psoriasis
... My first, and most earnest, acknowledgment must go to my advisor and chair of my thesis examination committee, Dr. Anne Bowcock. It is difficult to overstate my gratitude to Anne. It was such a great honor and pleasant to work with Anne and during the past 6 years, she has been giving me enthusiasti ...
... My first, and most earnest, acknowledgment must go to my advisor and chair of my thesis examination committee, Dr. Anne Bowcock. It is difficult to overstate my gratitude to Anne. It was such a great honor and pleasant to work with Anne and during the past 6 years, she has been giving me enthusiasti ...
To Я or Not To Я: Estrogen Receptors and Ovarian Function
... of age compared with wild type (24). This phenotype was not impacted by estradiol replacement from wk 7–10, arguing that the impact of estrogen deficiency may be manifest at the time of early follicle formation from the germ cell syncytium or may represent earlier or enhanced activation of the ordin ...
... of age compared with wild type (24). This phenotype was not impacted by estradiol replacement from wk 7–10, arguing that the impact of estrogen deficiency may be manifest at the time of early follicle formation from the germ cell syncytium or may represent earlier or enhanced activation of the ordin ...
Finding Eukaryotic Open reading frames.
... • Gene density is much lower; genes are further apart and can vary significantly between chromosomes (~ 1.5% of human DNA is CDS). • The mRNA is monocistronic (one promoter per gene; N.B prokaryotes generally are organised in operons) moreover; A DNA sequence is transcribed into one mRNA sequences [ ...
... • Gene density is much lower; genes are further apart and can vary significantly between chromosomes (~ 1.5% of human DNA is CDS). • The mRNA is monocistronic (one promoter per gene; N.B prokaryotes generally are organised in operons) moreover; A DNA sequence is transcribed into one mRNA sequences [ ...
New Vistas on Amygdala Networks in Conditioned Fear
... et al. 1998; Shumyatsky et al. 2002) all implicate the amygdala in the acquisition of learned fear. Second, findings from animal studies have been confirmed in humans with functional magnetic resonance imaging (fMRI) techniques (Buchel et al. 1998; LaBar et al. 1998; Whalen et al. 1998), increasing ...
... et al. 1998; Shumyatsky et al. 2002) all implicate the amygdala in the acquisition of learned fear. Second, findings from animal studies have been confirmed in humans with functional magnetic resonance imaging (fMRI) techniques (Buchel et al. 1998; LaBar et al. 1998; Whalen et al. 1998), increasing ...
Table S3. Transcription factor binding sites identified in haplotypes
... [40,41]. It is therefore a possible segmentation and/or neurogenic regulator (feedback) of ftz —a gene known to regulate Abdominal A [42]. Is a heterodimer formed by C-JUN and C-FOS. This association is required for binding to the promoter region of many genes. Its involvement in ftz regulation duri ...
... [40,41]. It is therefore a possible segmentation and/or neurogenic regulator (feedback) of ftz —a gene known to regulate Abdominal A [42]. Is a heterodimer formed by C-JUN and C-FOS. This association is required for binding to the promoter region of many genes. Its involvement in ftz regulation duri ...
Yeast whole-genome analysis of conserved regulatory motifs
... • Gfi expression Gfi-1 motif depletion in enhancers • Prediction: Gfi-1 large-scale repression of non-K562 Motif created Gfi-1 recruited enhancer repressed ...
... • Gfi expression Gfi-1 motif depletion in enhancers • Prediction: Gfi-1 large-scale repression of non-K562 Motif created Gfi-1 recruited enhancer repressed ...
Convergent evolution of complex regulatory
... and B). However, although the profiles shared many interactions, they also displayed differences with contacts observed in digits but not in GT and vice versa (Fig. 2C). Hoxd13 interaction peaks were aligned with both evolutionary conserved noncoding sequences and the GT H3K27 acetylation profile (f ...
... and B). However, although the profiles shared many interactions, they also displayed differences with contacts observed in digits but not in GT and vice versa (Fig. 2C). Hoxd13 interaction peaks were aligned with both evolutionary conserved noncoding sequences and the GT H3K27 acetylation profile (f ...
Supplementary Figure Legends (doc 52K)
... Supplementary Figure S2. Distribution of the ‘heavy’ and ‘light’ DNA in separated SIP fractions. The top of each panel shows the DGGE profiles of bacterial PCR products from separated (a) [13C]-phenanthrene fractions aligned to equivalent [12C]-phenanthrene fractions, (b) [13C]naphthalene fractions ...
... Supplementary Figure S2. Distribution of the ‘heavy’ and ‘light’ DNA in separated SIP fractions. The top of each panel shows the DGGE profiles of bacterial PCR products from separated (a) [13C]-phenanthrene fractions aligned to equivalent [12C]-phenanthrene fractions, (b) [13C]naphthalene fractions ...
Chapter 3: Molecular Biology Problems
... revert to any other subtype of S.) Based on this, why was it essential that they use a mixture of R(II) and heat-killed SIII instead of a mixture of R(II) and heat-killed SII? ...
... revert to any other subtype of S.) Based on this, why was it essential that they use a mixture of R(II) and heat-killed SIII instead of a mixture of R(II) and heat-killed SII? ...
Developmental Biology BY1101 P. Murphy Lecture 10 Master
... their approximate location on the genetic map. The next step was to actually isolate the genes. The burning question at the time was, what kind of proteins are produced by genes that have such a profound effect on the development of the body plan. Among the first genes to be cloned (physically isola ...
... their approximate location on the genetic map. The next step was to actually isolate the genes. The burning question at the time was, what kind of proteins are produced by genes that have such a profound effect on the development of the body plan. Among the first genes to be cloned (physically isola ...
Site-Specific Integration of Transgenes in
... previously placed in a plant genome. The integrated transgene now flanked by two recognition sites is vulnerable to excision. Transient Cre expression and the use of mutant lox sites to create two less compatible sites after integration helped reduce the subsequent excision in tobacco (Nicotiana tab ...
... previously placed in a plant genome. The integrated transgene now flanked by two recognition sites is vulnerable to excision. Transient Cre expression and the use of mutant lox sites to create two less compatible sites after integration helped reduce the subsequent excision in tobacco (Nicotiana tab ...
Extended Life-Span and Stress Resistance in Drosophila
... which is high in wild-type cells, is decreased in mutations that extend longevity. • Stress resistance proteins appear to have no role in replicative longevity (because deletion of stress resistant transcription factors Msn2/Msn4 has no effect) ...
... which is high in wild-type cells, is decreased in mutations that extend longevity. • Stress resistance proteins appear to have no role in replicative longevity (because deletion of stress resistant transcription factors Msn2/Msn4 has no effect) ...
TNFα signals through specialized factories where responsive coding
... small? Does it mean that the vast majority of reads in the 4C -Seq readout are just hits on the same small number of contacts? Does it mean that the library contacts are primarily the high frequency contacts while the additional contacts revealed by the Seq approach are primarily much lower probabil ...
... small? Does it mean that the vast majority of reads in the 4C -Seq readout are just hits on the same small number of contacts? Does it mean that the library contacts are primarily the high frequency contacts while the additional contacts revealed by the Seq approach are primarily much lower probabil ...
PDF
... genes that are also used sex-nonspecifically in other tissues. The array of processes regulated by dsx is complex, as different genes are regulated by dsx in all cell and tissue types examined (for reviews, see Christiansen et al., 2002; Camara et al., 2008). Of the dsx-regulated genes that have bee ...
... genes that are also used sex-nonspecifically in other tissues. The array of processes regulated by dsx is complex, as different genes are regulated by dsx in all cell and tissue types examined (for reviews, see Christiansen et al., 2002; Camara et al., 2008). Of the dsx-regulated genes that have bee ...
current micro 40/5 - Bashan Foundation
... RNA preparation. The heterocyst fraction was controlled microscopically and revealed no contaminating vegetative cells. Isolation of total RNA. Total RNA from both A. variabilis and A. nidulans was isolated by a combination of different standard techniques with the RNeasy Kit supplied by Qiagen (D-H ...
... RNA preparation. The heterocyst fraction was controlled microscopically and revealed no contaminating vegetative cells. Isolation of total RNA. Total RNA from both A. variabilis and A. nidulans was isolated by a combination of different standard techniques with the RNeasy Kit supplied by Qiagen (D-H ...
- bioRxiv
... unlike the situation observed in single cell expression noise experiments, we found no statistically significant negative correlation between and expression level (Fig S1). Therefore, to examine quantitatively the effect of gene dose reduction on expression variability, we pooled values for all hemi ...
... unlike the situation observed in single cell expression noise experiments, we found no statistically significant negative correlation between and expression level (Fig S1). Therefore, to examine quantitatively the effect of gene dose reduction on expression variability, we pooled values for all hemi ...
P D G E
... Microarray technologyi provides an opportunity to monitor mRNA levels of expression of thousands of genes simultaneously in a single experiment. The enormous amount of data produced by this high throughput approach presents a challenge for data analysis: to extract meaningful patterns, to evaluate i ...
... Microarray technologyi provides an opportunity to monitor mRNA levels of expression of thousands of genes simultaneously in a single experiment. The enormous amount of data produced by this high throughput approach presents a challenge for data analysis: to extract meaningful patterns, to evaluate i ...