multicopy gene family evolution on primate y chromosomes
... Contrary to previous theories, the Y chromosome is an important determinant of male phenotype [15–17]. The Y chromosome has been found to be associated with male fertility in humans [18] and even less obvious traits like lifespan [19] and locomotive activity [20] in Drosophila species. Therefore, an ...
... Contrary to previous theories, the Y chromosome is an important determinant of male phenotype [15–17]. The Y chromosome has been found to be associated with male fertility in humans [18] and even less obvious traits like lifespan [19] and locomotive activity [20] in Drosophila species. Therefore, an ...
Control of Cleavage Cycles in Drosophila Embryos by fru¨ hstart
... have not yet been described in any other species. We generated antibodies to the frs protein and confirmed their specificity by showing that they fail to stain frsdeficient embryos (Figures 2I–2L). On a cellular level, Frs appears to be excluded from the nucleus, despite its positive charge and a si ...
... have not yet been described in any other species. We generated antibodies to the frs protein and confirmed their specificity by showing that they fail to stain frsdeficient embryos (Figures 2I–2L). On a cellular level, Frs appears to be excluded from the nucleus, despite its positive charge and a si ...
Expression and characterization of 1
... The enzyme 1-aminocyclopropane-1-carboxylate deaminase (ACCD) converts ACC, the precursor of the plant hormone ethylene, to aketobutyrate and ammonium. This enzyme has been identified in soil bacteria and has been proposed to play a key role in microbe-plant association. A soluble recombinant ACCD f ...
... The enzyme 1-aminocyclopropane-1-carboxylate deaminase (ACCD) converts ACC, the precursor of the plant hormone ethylene, to aketobutyrate and ammonium. This enzyme has been identified in soil bacteria and has been proposed to play a key role in microbe-plant association. A soluble recombinant ACCD f ...
What Size Are Your Genes?
... DILUTE concentrated (50X) buffer with distilled water to create 1X buffer (see Table A). MIX agarose powder with 1X buffer in a 250 ml flask (see Table A). DISSOLVE agarose powder by boiling the solution. MICROWAVE the solution on high for 1 minute. Carefully REMOVE the flask from the microwave and MI ...
... DILUTE concentrated (50X) buffer with distilled water to create 1X buffer (see Table A). MIX agarose powder with 1X buffer in a 250 ml flask (see Table A). DISSOLVE agarose powder by boiling the solution. MICROWAVE the solution on high for 1 minute. Carefully REMOVE the flask from the microwave and MI ...
Novel Regulation of Cardiac Metabolism and Homeostasis by the
... Abstract—Adrenomedullin (AM) was identified as a vasodilating and hypotensive peptide mainly produced by the cardiovascular system. The AM receptor calcitonin receptor-like receptor associates with receptor activity-modifying protein (RAMP), one of the subtypes of regulatory proteins. Among knockout ...
... Abstract—Adrenomedullin (AM) was identified as a vasodilating and hypotensive peptide mainly produced by the cardiovascular system. The AM receptor calcitonin receptor-like receptor associates with receptor activity-modifying protein (RAMP), one of the subtypes of regulatory proteins. Among knockout ...
Genes and Genetic Testing in Hereditary Ataxias
... but this occurs more rarely. Many individuals have repeats at an intermediate length, resulting in incomplete penetrance of the disease, but these are more likely to expand in future generations. Expansion of repeat regions can therefore appear as sporadic cases when the repeat is newly expanded, as ...
... but this occurs more rarely. Many individuals have repeats at an intermediate length, resulting in incomplete penetrance of the disease, but these are more likely to expand in future generations. Expansion of repeat regions can therefore appear as sporadic cases when the repeat is newly expanded, as ...
DNA Evidence: Probability, Population Genetics, and the Courts
... 7. See David H. Kaye, The Admissibility ofDNA Testing, 13 CARDOZO L. REV. 353, 357 n.17 (1991). A case that is representative of this epoch is Cobey v. State, 559 A.2d 391 (Md. Ct. Spec. App. 1988). A man forced a woman jogging in a park into the woods, where, as the court of appeals put it, he "rav ...
... 7. See David H. Kaye, The Admissibility ofDNA Testing, 13 CARDOZO L. REV. 353, 357 n.17 (1991). A case that is representative of this epoch is Cobey v. State, 559 A.2d 391 (Md. Ct. Spec. App. 1988). A man forced a woman jogging in a park into the woods, where, as the court of appeals put it, he "rav ...
PPT
... of markers to get signal in an association study, but you get very high spatial resolution. ...
... of markers to get signal in an association study, but you get very high spatial resolution. ...
Type I Factor XI11 Deficiency Is Caused By a
... Nucleotide sequence analysis. The amplified DNA samples were digested with restriction enzymes to generate the proper ends for ligation into sequencing vectors. The digested samples were applied to a 0.8% agarose gel, electroeluted, and then subcloned into M13mp18 or M13mp19 (GIBCO-BRL, Gathersburg, ...
... Nucleotide sequence analysis. The amplified DNA samples were digested with restriction enzymes to generate the proper ends for ligation into sequencing vectors. The digested samples were applied to a 0.8% agarose gel, electroeluted, and then subcloned into M13mp18 or M13mp19 (GIBCO-BRL, Gathersburg, ...
Käfer, E. and D. Luk
... unlinked to all mus and many other markers on linkage groups IV and V (in the absence of transThe mutant mus(FK128), on the other locations). hand, produces two types of progeny in backcrosses which show different survival on MMS. It is uncertain whether is this related to the inability to identify ...
... unlinked to all mus and many other markers on linkage groups IV and V (in the absence of transThe mutant mus(FK128), on the other locations). hand, produces two types of progeny in backcrosses which show different survival on MMS. It is uncertain whether is this related to the inability to identify ...
PDF - 2.3 MB
... (c 12 pts.) Suppose that one of the T4 mutants (which can only grow on an E. coil strain carrying a UGA nonsense suppressor) was generated by a mutagen that causes transition mutations (CoG to T°A or ToA to COG). Using the genetic code (on the front of the exam) determine which codon(s) in wild type ...
... (c 12 pts.) Suppose that one of the T4 mutants (which can only grow on an E. coil strain carrying a UGA nonsense suppressor) was generated by a mutagen that causes transition mutations (CoG to T°A or ToA to COG). Using the genetic code (on the front of the exam) determine which codon(s) in wild type ...
Package ‘GenomicFeatures’ October 14, 2014
... strand can also be a list-like object, in which case it indicates the strand of each exon, individually. Thus it must have the same shape as RangesList object transcripts (i.e. same length plus strand[[i]] must have the same length as transcripts[[i]] for all i). strand can only contain "+" and/or " ...
... strand can also be a list-like object, in which case it indicates the strand of each exon, individually. Thus it must have the same shape as RangesList object transcripts (i.e. same length plus strand[[i]] must have the same length as transcripts[[i]] for all i). strand can only contain "+" and/or " ...
Chapter 4 Extension Activity
... When solving genetic problems that involve sex-linkage, the symbols X and Y are used, but these differ from other genetic problems because X and Y are not symbols for genes, they represent whole chromosomes. These sex chromosomes do not only carry genes that control sexual development, they have oth ...
... When solving genetic problems that involve sex-linkage, the symbols X and Y are used, but these differ from other genetic problems because X and Y are not symbols for genes, they represent whole chromosomes. These sex chromosomes do not only carry genes that control sexual development, they have oth ...
Spinal Muscular Atrophy
... In humans, the number of SMN2 genes varies from person to person [8] Generally, patients with less severe forms of SMA have more SMN2 copies There are exceptions; therefore SMN2 copy number does not predict what will happen with an individual patient ...
... In humans, the number of SMN2 genes varies from person to person [8] Generally, patients with less severe forms of SMA have more SMN2 copies There are exceptions; therefore SMN2 copy number does not predict what will happen with an individual patient ...
The Role of the Susceptibility Gene in the Pathogenesis of Age
... of vitamin D deficient and CFH SNPs on the susceptibility of AMD [10]. Interesting, the major risk allele of HTRA1 in AMD patients is significantly higher in Asia [11,12]. Those results suggest that the variation of SNPs in different population is responsible for the development of AMD. Notably, a n ...
... of vitamin D deficient and CFH SNPs on the susceptibility of AMD [10]. Interesting, the major risk allele of HTRA1 in AMD patients is significantly higher in Asia [11,12]. Those results suggest that the variation of SNPs in different population is responsible for the development of AMD. Notably, a n ...
chicken.db - Bioconductor
... indicates the chromosome. Due to inconsistencies that may exist at the time the object was built, these vectors may contain more than one chromosome and/or location. If the chromosomal location is unknown, the vector will contain an NA. Chromosomal locations on both the sense and antisense strands a ...
... indicates the chromosome. Due to inconsistencies that may exist at the time the object was built, these vectors may contain more than one chromosome and/or location. If the chromosomal location is unknown, the vector will contain an NA. Chromosomal locations on both the sense and antisense strands a ...
INFINITI CYP450 2C19+ Assay
... Other poor metabolizer phenotypes include *4, *5, *6, *7 and *8 which have all been shown to have a nonfunctional response. *9 and *10 are very similar (poor metabolizer phenotypes) but have a decreased enzymatic activity response. *17 is the one phenotype that has an opposite effect. It has been sh ...
... Other poor metabolizer phenotypes include *4, *5, *6, *7 and *8 which have all been shown to have a nonfunctional response. *9 and *10 are very similar (poor metabolizer phenotypes) but have a decreased enzymatic activity response. *17 is the one phenotype that has an opposite effect. It has been sh ...
Sporadic Hypertrophic Cardiomyopathy Due to De Novo Myosin
... from probands and their first-degree relatives. Clinical, electrocardiographic, and echocardiographic assessments were performed as described previously (22). The diagnosis of hypertrophic cardiomyopathy was based on the demonstration of unexplained left, right or biventricular hypertrophy. An indiv ...
... from probands and their first-degree relatives. Clinical, electrocardiographic, and echocardiographic assessments were performed as described previously (22). The diagnosis of hypertrophic cardiomyopathy was based on the demonstration of unexplained left, right or biventricular hypertrophy. An indiv ...
Patterns of Segmental Duplication in the Human Genome
... of each DNA segment and hits with less than 90% similarity were discarded. For the remaining Blast hits, we combined hits that are less than 50 kb apart on the same chromosome into one tentative duplication block. After this step, we took out the sequences of each block pair plus the 10-kb sequences ...
... of each DNA segment and hits with less than 90% similarity were discarded. For the remaining Blast hits, we combined hits that are less than 50 kb apart on the same chromosome into one tentative duplication block. After this step, we took out the sequences of each block pair plus the 10-kb sequences ...
Resistance genes in barley - Journal of Applied Genetics
... used to isolate a family of resistance gene analogs (RGAs) through a polymerase chain reaction (PCR) cloning approach. This class of R gene belongs to a superfamily that is present in both dicotyledons and monocotyledons, as suggested from sequence comparisons of those that have been isolated. Such ...
... used to isolate a family of resistance gene analogs (RGAs) through a polymerase chain reaction (PCR) cloning approach. This class of R gene belongs to a superfamily that is present in both dicotyledons and monocotyledons, as suggested from sequence comparisons of those that have been isolated. Such ...
Genetic Transformation of Poinsettia (Euphórbia
... In nature, A. tumefaciens will infect dicotyledonous plants to produce crown-gall disease by transferring genes coding for crown-gall into the plant (Hoekema et al. 1983; Stachel & Nester 1986). This is done by a virulence region (vir-region) located in a tumour inducing plasmid (Tiplasmid) in the A ...
... In nature, A. tumefaciens will infect dicotyledonous plants to produce crown-gall disease by transferring genes coding for crown-gall into the plant (Hoekema et al. 1983; Stachel & Nester 1986). This is done by a virulence region (vir-region) located in a tumour inducing plasmid (Tiplasmid) in the A ...
PERSPECTIVES IN HUMAN GENETICS Mendelian Inheritance in
... number, and the initial paragraph indicates the entry number of the gene(s) in which the mutation(s) is described. Gene entries have an asterisk preceding the unique number. Entries that contain both phenotype and gene information are flagged with a plus sign (⫹); X-linked examples include HPRT (MI ...
... number, and the initial paragraph indicates the entry number of the gene(s) in which the mutation(s) is described. Gene entries have an asterisk preceding the unique number. Entries that contain both phenotype and gene information are flagged with a plus sign (⫹); X-linked examples include HPRT (MI ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
... ATF2 is activated by stress kinases, including JNK (MAPK8, MAPK9, MAPK10) and p38 (MAPK1, MAPK11, MAPK12, MAPK13, MAPK14) and is implicated in transcriptional regulation of immediate early genes regulating stress and DNA damage responses (Gupta et al., 1995; van Dam et al., 1995) and cell cycle cont ...
... ATF2 is activated by stress kinases, including JNK (MAPK8, MAPK9, MAPK10) and p38 (MAPK1, MAPK11, MAPK12, MAPK13, MAPK14) and is implicated in transcriptional regulation of immediate early genes regulating stress and DNA damage responses (Gupta et al., 1995; van Dam et al., 1995) and cell cycle cont ...
Maternal-Effect Genes That Alter the Fate Map of the Drosophila
... protein at normal levels. (d) wosrD/waP! All abdominal denticles are absent. sp, spiracles. (e) ezuPJ/ezuP< Note the anterior shift of the first ftz stripe (arrowhead), the abnormally wide second stripe, and the compression of the posterior stripes (bracket). (f) exupJ/exup< The pattern of thoracic ...
... protein at normal levels. (d) wosrD/waP! All abdominal denticles are absent. sp, spiracles. (e) ezuPJ/ezuP< Note the anterior shift of the first ftz stripe (arrowhead), the abnormally wide second stripe, and the compression of the posterior stripes (bracket). (f) exupJ/exup< The pattern of thoracic ...
Oxalate decarboxylase of the white-rot fungus
... Dichomitus squalens, and cloned the corresponding Ds-odc gene. The primary structure of the Ds-ODC protein contains two conserved Mn-binding cupin motifs, but at the N-terminus, a unique, approximately 60 aa alanine-serine-rich region is found. Real-time quantitative RT-PCR analysis confirmed gene e ...
... Dichomitus squalens, and cloned the corresponding Ds-odc gene. The primary structure of the Ds-ODC protein contains two conserved Mn-binding cupin motifs, but at the N-terminus, a unique, approximately 60 aa alanine-serine-rich region is found. Real-time quantitative RT-PCR analysis confirmed gene e ...