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CaNCer aND THe ePIGeNOMe
CaNCer aND THe ePIGeNOMe

... A CpG island consists of a stretch of some 300 to 3,000 DNA bases where clusters of cytosine and guanine dinucleotides make up about half the sequence  1 . More than 60% of these islands are associated with the promoter regions of genes and are not methylated in genes that are actively transcribed. ...
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... a) Point mutation = substitution of single base pair  Changes only one amino acid (if any!) ...
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GenesEnv

... (come from the same parent plant) from Yarrow plant clones grew differently at three different altitudes  Cuttings from one plant grew tall at the lowest and the highest elevation  But a third cutting remained short at midelevation  Even though these plants were genetically identical, their pheno ...
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... on the reproduction. In a majority of the angiosperm plants, the carpels and stamens are in the same flower and represent the female and male reproductive tissue respectively, this is called a hermaphroditic flower. The pollination needs a medium, for example, wind or insects. The insect pollination ...
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... • Which ENSEMBL transcript corresponds to the RefSeq gene? • How does sequence conservation correspond to the exon structure? • Which RefSeq genes are upstream and downstream of p53 on the same strand? What is roughly the distance? • Do a similar search using UCSC and ENSEMBL! Which one is easier to ...
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... After inserting their RNA into the cell – the enzyme uses the viral RNA to transcript itself into the DNA of the cell – after which it will be translated and produced. 5. List four types of RNA and how they differ from one another in function. mRNA carries information from DNA to ribosome tRNA bond ...
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... The sequencing of the human genome lead to some surprises concerning the number of genes. The number of human genes seems to be around 30,000, much less than expected. This number is not a lot higher than the number of genes of “lower” organisms, like the worm Caenorhabditis elegans with its more th ...
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... Epigenetics looks at the impact on genome function not based on sequence variation but on differences of heterochromatin and euchromatin. In the “Lick Your Rats” video, rat pups who grew to be aggressive had __________ ...
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... Repressors cease expression of genes. They block RNA polymerase from binding. When bound to the operator, there is no gene expression. Activators activate gene expression. They make it easier for the RNA polymerase to bind. When bound to the operator, there is gene expression. They are both control ...
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... 5. Regulation of RNA processing, RNA stability, and translation a. Alternative splicing regulates which exons occur in an RNA transcript, allowing different polypeptides to be made from the same structural gene b. The stability of mRNA influences mRNA concentration c. Double-stranded RNA can silence ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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