Ophthalmic Genetics Update Genetics and Genomics of
... PEX glaucoma suggesting that the LOXL1 gene may contribute to disease onset rather than to IOP elevation and subsequent glaucoma. In support of this observation, no association has been reported with any other type of glaucoma, including POAG, normal tension glaucoma, pigmentary glaucoma, or angle-c ...
... PEX glaucoma suggesting that the LOXL1 gene may contribute to disease onset rather than to IOP elevation and subsequent glaucoma. In support of this observation, no association has been reported with any other type of glaucoma, including POAG, normal tension glaucoma, pigmentary glaucoma, or angle-c ...
PPT
... between genetically diverse PSI+ strains. How can the cause be genetic and non-genetic (protein aggregates) at the same time? ...
... between genetically diverse PSI+ strains. How can the cause be genetic and non-genetic (protein aggregates) at the same time? ...
Ethanol exposure affects gene expression in the embryonic
... types during vertebrate embryogenesis (Durston et al., 1998; Means and Gudas, 1995). The importance of RA in normal embryonic development has been demonstrated by treating embryos with RA or inducing Vitamin A deficiency, both resulting in severe teratogenic effects (Cohlan, 1953; Kessel, 1992; Made ...
... types during vertebrate embryogenesis (Durston et al., 1998; Means and Gudas, 1995). The importance of RA in normal embryonic development has been demonstrated by treating embryos with RA or inducing Vitamin A deficiency, both resulting in severe teratogenic effects (Cohlan, 1953; Kessel, 1992; Made ...
Gene Section BIN1 (bridging integrator 1) Atlas of Genetics and Cytogenetics
... exchange factors (Rab GEFs) and the sorting nexin protein Snx4. Complexes of neuronal Amph-I with neuron-specific isoforms of Bin1 (Amph-II) have been implicated in synaptic vesicle recycling in the brain. Genetic studies of the Bin1 homolog in budding yeast indicate an essential role in endocytosis ...
... exchange factors (Rab GEFs) and the sorting nexin protein Snx4. Complexes of neuronal Amph-I with neuron-specific isoforms of Bin1 (Amph-II) have been implicated in synaptic vesicle recycling in the brain. Genetic studies of the Bin1 homolog in budding yeast indicate an essential role in endocytosis ...
Genetics - York University
... How was evolution possible if Mendel’ Mendel’s conception was correct? Darwin required that subsequent generations of a species exhibit a set of characteristics that varied, but around a different center. • Answer: Mutations. ...
... How was evolution possible if Mendel’ Mendel’s conception was correct? Darwin required that subsequent generations of a species exhibit a set of characteristics that varied, but around a different center. • Answer: Mutations. ...
Identification and Isolation of Dominant Susceptibility Loci for
... Rheumatoid arthritis is a chronic inflammatory autoimmune disorder, controlled by multiple genes as well as environmental factors. With animal models, like the pristane-induced arthritis (PIA) in rats, it is possible to reduce the environmental effects and the genetic heterogeneity to identify chrom ...
... Rheumatoid arthritis is a chronic inflammatory autoimmune disorder, controlled by multiple genes as well as environmental factors. With animal models, like the pristane-induced arthritis (PIA) in rats, it is possible to reduce the environmental effects and the genetic heterogeneity to identify chrom ...
Moore BA, Gonzalez Aviles GD, Larkins CE, Hillman MJ, Caspary T. Mamm Genome. 2010 Aug;21(7-8):350-60. Mitochondrial retention of Opa1 is required for mouse embryogenesis
... Opa1 is one of three GTPases known to regulate mitochondrial fusion. When Opa1 is knocked down in cells, mitochondrial fragmentation results (Chen et al. 2005; Cipolat et al. 2004; Griparic et al. 2004; Olichon et al. 2003). To determine whether the mutation we found in Opa1 disrupts Opa1 function, ...
... Opa1 is one of three GTPases known to regulate mitochondrial fusion. When Opa1 is knocked down in cells, mitochondrial fragmentation results (Chen et al. 2005; Cipolat et al. 2004; Griparic et al. 2004; Olichon et al. 2003). To determine whether the mutation we found in Opa1 disrupts Opa1 function, ...
Gekko 4_1 July 29
... information about the mechanism of albinism in other species. There may be some similarity between the tyrosinase positive albinism in leopard geckos, for example, and several human and murine forms of oculocutaneous albinism, an assortment of disorders that result in reduced or no melanin productio ...
... information about the mechanism of albinism in other species. There may be some similarity between the tyrosinase positive albinism in leopard geckos, for example, and several human and murine forms of oculocutaneous albinism, an assortment of disorders that result in reduced or no melanin productio ...
Genetic tools for manipulating Acinetobacter baumannii genome: an
... chromosome by the Campbell-type mechanism (Fig. 2). This is a single-crossover event that was originally proposed by Alan Campbell for the integration of bacteriophage into the E. coli genome (Campbell, 2007). For integration to work successfully, the key recombination protein RecA is required. The ...
... chromosome by the Campbell-type mechanism (Fig. 2). This is a single-crossover event that was originally proposed by Alan Campbell for the integration of bacteriophage into the E. coli genome (Campbell, 2007). For integration to work successfully, the key recombination protein RecA is required. The ...
Control of Hepatic Gluconeogenesis During the Transition Period
... wall and other portions of the gastrointestinal tract into the hepatic portal vein. The provision of glucogenic precursors is critical for hepatic glucose production. In vitro experiments using bovine hepatocytes indicate maximal gluconeogenesis from propionate, lactate, and glycerol that occurs bet ...
... wall and other portions of the gastrointestinal tract into the hepatic portal vein. The provision of glucogenic precursors is critical for hepatic glucose production. In vitro experiments using bovine hepatocytes indicate maximal gluconeogenesis from propionate, lactate, and glycerol that occurs bet ...
The splanchnic mesodermal plate directs spleen and
... supports the dorsal pancreatic bud (Fig. 1D) lying ventral to the splenic rudiment. Expression of other genes implicated in spleen development confirmed that this region of the embryo participates in spleen formation. In Xenopus, Nkx2.5 is expressed during early stages of spleen development (Patters ...
... supports the dorsal pancreatic bud (Fig. 1D) lying ventral to the splenic rudiment. Expression of other genes implicated in spleen development confirmed that this region of the embryo participates in spleen formation. In Xenopus, Nkx2.5 is expressed during early stages of spleen development (Patters ...
The splanchnic mesodermal plate directs spleen and
... supports the dorsal pancreatic bud (Fig. 1D) lying ventral to the splenic rudiment. Expression of other genes implicated in spleen development confirmed that this region of the embryo participates in spleen formation. In Xenopus, Nkx2.5 is expressed during early stages of spleen development (Patters ...
... supports the dorsal pancreatic bud (Fig. 1D) lying ventral to the splenic rudiment. Expression of other genes implicated in spleen development confirmed that this region of the embryo participates in spleen formation. In Xenopus, Nkx2.5 is expressed during early stages of spleen development (Patters ...
Distribution and structural variation of the she pathogenicity island in
... the PCR detection of the markers, the same strains were analysed by Southern hybridisation. As int is common to all Shigella strains carrying markers of the PAI, strains were probed with a fragment of the int gene. Southern analysis with the int probe con®rmed that although the positive control stra ...
... the PCR detection of the markers, the same strains were analysed by Southern hybridisation. As int is common to all Shigella strains carrying markers of the PAI, strains were probed with a fragment of the int gene. Southern analysis with the int probe con®rmed that although the positive control stra ...
RET Proto-Oncogene
... Somatic RET mutations at codons 608, 611, 618, 629, 630, 634, 639, 641, 918, or 922 are found in approximately 25% of patients with sporadic MTC, with mutations at codon 918 occurring most frequently (81–89). As with germline 918 mutations, the somatic 918 mutations are associated with aggressive MT ...
... Somatic RET mutations at codons 608, 611, 618, 629, 630, 634, 639, 641, 918, or 922 are found in approximately 25% of patients with sporadic MTC, with mutations at codon 918 occurring most frequently (81–89). As with germline 918 mutations, the somatic 918 mutations are associated with aggressive MT ...
Dickkopf1 Is Required for Embryonic Head Induction
... induction in the mouse embryo requires not only a functional AVE but also the node and its AME derivative (Bachiller et al., 2000; Shawlot et al., 1999; Tam and Steiner, 1999). Dkk1 is expressed in the AVE as well as the AME (Glinka et al., 1998; Pearce et al., 1999). In order to determine which of ...
... induction in the mouse embryo requires not only a functional AVE but also the node and its AME derivative (Bachiller et al., 2000; Shawlot et al., 1999; Tam and Steiner, 1999). Dkk1 is expressed in the AVE as well as the AME (Glinka et al., 1998; Pearce et al., 1999). In order to determine which of ...
Research in Microbiology
... sporulation deficiency of kinA kinB double mutant of B. subtilis, but not of B. subtilis spo0B mutant. These results indicated that Kin1377 requires B. subtilis Spo0B and possibly Spo0F to transfer phosphate to B. subtilis Spo0A. Another putative kinase, Kin1038, slightly restored the sporulation de ...
... sporulation deficiency of kinA kinB double mutant of B. subtilis, but not of B. subtilis spo0B mutant. These results indicated that Kin1377 requires B. subtilis Spo0B and possibly Spo0F to transfer phosphate to B. subtilis Spo0A. Another putative kinase, Kin1038, slightly restored the sporulation de ...
MOLECULAR RECOGNITION AND RESPONSE IN POLLEN AND
... buds, which are unable to reject self pollen, and the increase in expression during subsequent flower development coincides with the acquisition of SI by the pistil. (This expression pattern makes it possible in some self-incompatible species to obtain plants homozygous for a particular S-haplotype ...
... buds, which are unable to reject self pollen, and the increase in expression during subsequent flower development coincides with the acquisition of SI by the pistil. (This expression pattern makes it possible in some self-incompatible species to obtain plants homozygous for a particular S-haplotype ...
Boundless Study Slides
... different gametes during meiosis. • Heterozygotes, which posess one dominant and one recessive allele, can receive each allele from either parent and will look identical to homozygous dominant individuals; the Law of Segregation supports Mendel's observed 3:1 phenotypic ratio. • Mendel proposed the ...
... different gametes during meiosis. • Heterozygotes, which posess one dominant and one recessive allele, can receive each allele from either parent and will look identical to homozygous dominant individuals; the Law of Segregation supports Mendel's observed 3:1 phenotypic ratio. • Mendel proposed the ...
Alarmingly High Segregation Frequencies of Quinolone Resistance
... Antibiotic resistance poses a major threat to human health. It is therefore important to characterize the frequency of resistance within natural bacterial environments. Many studies have focused on characterizing the frequencies with which horizontally acquired resistance genes segregate within natu ...
... Antibiotic resistance poses a major threat to human health. It is therefore important to characterize the frequency of resistance within natural bacterial environments. Many studies have focused on characterizing the frequencies with which horizontally acquired resistance genes segregate within natu ...
Gro and Eve co-regulate early boundaries - Development
... 1806 M. Kobayashi and others An alanine/proline-rich repression domain was mapped in Eve using transient transfection assays (Han and Manley, 1993; Jaynes and O’Farrell, 1991), and similar repression domains have been found in other proteins (Hanna-Rose and Hansen, 1996). For one of these repressor ...
... 1806 M. Kobayashi and others An alanine/proline-rich repression domain was mapped in Eve using transient transfection assays (Han and Manley, 1993; Jaynes and O’Farrell, 1991), and similar repression domains have been found in other proteins (Hanna-Rose and Hansen, 1996). For one of these repressor ...
Origin of the catalytic activity of bovine seminal ribonuclease against
... identified in these experiments as being important for duplex activity, is prepared. This is the most powerful catalyst within this subfamily yet observed, some 46-fold more active against duplex RNA than RNase A. ...
... identified in these experiments as being important for duplex activity, is prepared. This is the most powerful catalyst within this subfamily yet observed, some 46-fold more active against duplex RNA than RNase A. ...
DNA supercoiling factor contributes to dosage
... dramatic reduction in the viability of males carrying both GAL4 and UAS-IRscf (Fig. 1B). Most of these males died during the pupal stage, and the few individuals that did survive to adulthood died shortly after eclosion. The effects on male viability do not appear to be due to position effects, as t ...
... dramatic reduction in the viability of males carrying both GAL4 and UAS-IRscf (Fig. 1B). Most of these males died during the pupal stage, and the few individuals that did survive to adulthood died shortly after eclosion. The effects on male viability do not appear to be due to position effects, as t ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.