Bioinformatics in Drug Design
... an alignment by estimating this ratio (= improvement over random). • In brief, each substitution score is the log-odds probability that amino acid a could change (mutate) into amino acid b through evolution, based on the constraints of our evolutionary model. [16] Substitution matrices – Sequence an ...
... an alignment by estimating this ratio (= improvement over random). • In brief, each substitution score is the log-odds probability that amino acid a could change (mutate) into amino acid b through evolution, based on the constraints of our evolutionary model. [16] Substitution matrices – Sequence an ...
17. Prof. K. P. Bhatia: Paroxysmal Movement Disorders
... All three of these disorders are linked to the same pericentromic region of chromosome 16 and thus are considered together. Szepetowski and colleagues (1998) first linked four French families with what they described as the ‘ICCA syndrome’ to the pericentromeric region of chromosome 16.12 Subsequent ...
... All three of these disorders are linked to the same pericentromic region of chromosome 16 and thus are considered together. Szepetowski and colleagues (1998) first linked four French families with what they described as the ‘ICCA syndrome’ to the pericentromeric region of chromosome 16.12 Subsequent ...
Gene Technology Regulation 2002
... Gene Technology Regulation 2002 Part 2 Interpretation and general operation [s 3B] ...
... Gene Technology Regulation 2002 Part 2 Interpretation and general operation [s 3B] ...
Eds., M. Kawaguchi, K. Misaki, H. Sato, T. Yokokawa, T.... and S. Tanabe, pp. 35–40.
... sulfur-containing amino acids such as cysteine or methionine can also scavenge HOCl, and these amino acids are present at high levels in the L-15 culture medium used in the organ culture (cysteine; 0.99 mM, methionine; 0.5 mM) compared with the supplemented taurine (0.8–800 µM) concentrations. It is ...
... sulfur-containing amino acids such as cysteine or methionine can also scavenge HOCl, and these amino acids are present at high levels in the L-15 culture medium used in the organ culture (cysteine; 0.99 mM, methionine; 0.5 mM) compared with the supplemented taurine (0.8–800 µM) concentrations. It is ...
TRIBOLIUM INFORMATION BULLETIN Number 7
... The tips of the elytra are divergent (resembling the dve condition in T.castaneum) with the split beginning sometimes at , but mostly one-third to one-fourth of the elytral length behind, the scutellum and gradually tapering towards the sides, the posterior edge of the elytron producing a flattened ...
... The tips of the elytra are divergent (resembling the dve condition in T.castaneum) with the split beginning sometimes at , but mostly one-third to one-fourth of the elytral length behind, the scutellum and gradually tapering towards the sides, the posterior edge of the elytron producing a flattened ...
Unveiling the physiological and molecular basis of Mycobacterium
... ABSTRACT .......................................................................................................................................... IV ...
... ABSTRACT .......................................................................................................................................... IV ...
Molecular Genetics of Bipolar Disorder and Related Traits
... research is fundamentally important to the field of medicine and to the elucidation of the basic mechanisms of biological systems. In this thesis different applications of statistical methods have been used to explore the genetic component of bipolar disorder and related traits. Here, 41 families af ...
... research is fundamentally important to the field of medicine and to the elucidation of the basic mechanisms of biological systems. In this thesis different applications of statistical methods have been used to explore the genetic component of bipolar disorder and related traits. Here, 41 families af ...
Mechanisms of Transcription-Replication
... the elongation rate for RNA polymerase is just 50 nucleotides (nt) per s (15); i.e., replication is approximately 20-fold faster than transcription. Since the two processes proceed simultaneously, frequent collisions between replication and transcription seem unavoidable (3, 38). Given that both pro ...
... the elongation rate for RNA polymerase is just 50 nucleotides (nt) per s (15); i.e., replication is approximately 20-fold faster than transcription. Since the two processes proceed simultaneously, frequent collisions between replication and transcription seem unavoidable (3, 38). Given that both pro ...
Organization and Integration of Large-scale Datasets for
... Mycoplasma pneumoniae, one of the smallest known self-replicating organisms, is a promising model organism in systems biology when aiming to assess understanding of an entire living cell. One of the key steps towards this goal is the design of mathematical models that describe the cellular processes ...
... Mycoplasma pneumoniae, one of the smallest known self-replicating organisms, is a promising model organism in systems biology when aiming to assess understanding of an entire living cell. One of the key steps towards this goal is the design of mathematical models that describe the cellular processes ...
ABA overlysensitive5 (ABO5), encoding a pentatricopeptide repeat
... and abi5 (Finkelstein and Lynch, 2000) are loss-of-function mutants. Seed germination of all five mutants is insensitive to ABA. The seed germination of the abo5 abi1-1, abo5 abi21, abo5 abi3-1, abo5 abi4-1 and abi5 abo5 double mutants had the same ABA-insensitive phenotype as the abi single mutants ...
... and abi5 (Finkelstein and Lynch, 2000) are loss-of-function mutants. Seed germination of all five mutants is insensitive to ABA. The seed germination of the abo5 abi1-1, abo5 abi21, abo5 abi3-1, abo5 abi4-1 and abi5 abo5 double mutants had the same ABA-insensitive phenotype as the abi single mutants ...
CTLA4 gene polymorphisms are associated with chronic bronchitis
... FBAT and HBAT. Using a SNP sliding window approach (adjacent sets of two and three SNPs), the results of global and haplotype-specific association statistics were determined. Values of p,0.05 from the analyses were considered the nominal significant levels. Considering that 15 sliding window haploty ...
... FBAT and HBAT. Using a SNP sliding window approach (adjacent sets of two and three SNPs), the results of global and haplotype-specific association statistics were determined. Values of p,0.05 from the analyses were considered the nominal significant levels. Considering that 15 sliding window haploty ...
Full-Text PDF
... amplify specific target sequences from three pathogens Neisseria gonorrhoeae, Salmonella enterica, and methicillin-resistant Staphylococcus aureus (MRSA) using genomic DNA [26]. They demonstrated detection in 20 min and a LoD of extracted DNA from between 10 and 100 cfu. Crannell et al. demonstrated ...
... amplify specific target sequences from three pathogens Neisseria gonorrhoeae, Salmonella enterica, and methicillin-resistant Staphylococcus aureus (MRSA) using genomic DNA [26]. They demonstrated detection in 20 min and a LoD of extracted DNA from between 10 and 100 cfu. Crannell et al. demonstrated ...
PDF
... in iron cycling [7, 13, 17]. Apparently, “Ferrovum”-related iron oxidisers prefer higher pH values and ferrous iron concentrations than the well-studied A. ferrooxidans [15]. The comparison of the microbial composition of the AMD springs Lower and Upper Red Eyes in the Appalachian Mountains (Pennsyl ...
... in iron cycling [7, 13, 17]. Apparently, “Ferrovum”-related iron oxidisers prefer higher pH values and ferrous iron concentrations than the well-studied A. ferrooxidans [15]. The comparison of the microbial composition of the AMD springs Lower and Upper Red Eyes in the Appalachian Mountains (Pennsyl ...
here - Glaucoma Genetics Lab
... Purpose: To both characterize the clinical features of large primary open angle glaucoma (POAG) pedigree from a village in southern India and to investigate the genetic basis of their disease. Materials and methods: Eighty-four members of a large pedigree received complete eye examinations including ...
... Purpose: To both characterize the clinical features of large primary open angle glaucoma (POAG) pedigree from a village in southern India and to investigate the genetic basis of their disease. Materials and methods: Eighty-four members of a large pedigree received complete eye examinations including ...
Molecular basis of the clinical variability of Rett syndrome
... The manuscript submitted by Elisa Scala for defending her Ph.D. in Medical Genetics is dealing with Rett Syndrome, a severe neurodevelopmental disorder that mostly affects females and that is characterised by a wide spectrum of clinical manifestations. The manuscript focuses on the molecular bases t ...
... The manuscript submitted by Elisa Scala for defending her Ph.D. in Medical Genetics is dealing with Rett Syndrome, a severe neurodevelopmental disorder that mostly affects females and that is characterised by a wide spectrum of clinical manifestations. The manuscript focuses on the molecular bases t ...
Molecular cloning of Per a 1 and definition of the cross
... Bd90K belong to the same family of Group 1 allergens. These allergens occur in multiple molecular forms with different molecular weights, which are the result of replication of approximately 100 amino acid repeats in the sequences. A detailed analysis of the Bla g 1 repeats and of the homology betwe ...
... Bd90K belong to the same family of Group 1 allergens. These allergens occur in multiple molecular forms with different molecular weights, which are the result of replication of approximately 100 amino acid repeats in the sequences. A detailed analysis of the Bla g 1 repeats and of the homology betwe ...
A Selective Sweep Driven by Pyrimethamine Treatment in Southeast
... assumed to have evolved multiple times because the genetic basis is simple and resistance can be selected easily in the laboratory. Yet our data clearly indicate a single origin of resistant dhfr alleles sampled over a large region of SE Asia. (2) The wide valley (;6 cM) of reduced variation around ...
... assumed to have evolved multiple times because the genetic basis is simple and resistance can be selected easily in the laboratory. Yet our data clearly indicate a single origin of resistant dhfr alleles sampled over a large region of SE Asia. (2) The wide valley (;6 cM) of reduced variation around ...
The Molecular Basis of Imidazolinone Herbicide Resistance in
... catalyses the condensation of two pyruvates to form acetolactate and also of pyruvate and alpha-ketobutyrate to form acetohydroxy acid (Miflin, 1971). ...
... catalyses the condensation of two pyruvates to form acetolactate and also of pyruvate and alpha-ketobutyrate to form acetohydroxy acid (Miflin, 1971). ...
The Role of TP53 in Cervical Carcinogenesis
... inactivation of p53 represents a key step in carcinogenesis. In the development of cervical cancer highrisk HPV infection is the leading event and the viral protein E6 has developed different mechanisms to neutralize the biological functions of p53. The most efficient way is to mediate the degradati ...
... inactivation of p53 represents a key step in carcinogenesis. In the development of cervical cancer highrisk HPV infection is the leading event and the viral protein E6 has developed different mechanisms to neutralize the biological functions of p53. The most efficient way is to mediate the degradati ...
Detecting copy number variants and runs of homozygosity on a
... aid in the identification of additional genetic variants to those yielded by the CNV data alone. Protocols for high-resolution SNP arrays can be time consuming whereas aCGH array protocols are less laborious, and as the gold-standard for CNV detection, well established in laboratory workflows. Recen ...
... aid in the identification of additional genetic variants to those yielded by the CNV data alone. Protocols for high-resolution SNP arrays can be time consuming whereas aCGH array protocols are less laborious, and as the gold-standard for CNV detection, well established in laboratory workflows. Recen ...
Histological classification and molecular genetics of meningiomas
... progesterone receptor, but this remains unproven.4,5 Another well-defined cause in those with young onset and no sex predilection is neurofibromatosis type 2 (NF2). Meningiomas (besides schwannomas) are hallmark features of this autosomal dominant disorder caused by germline mutations in the NF2 gene ...
... progesterone receptor, but this remains unproven.4,5 Another well-defined cause in those with young onset and no sex predilection is neurofibromatosis type 2 (NF2). Meningiomas (besides schwannomas) are hallmark features of this autosomal dominant disorder caused by germline mutations in the NF2 gene ...
Distribution and phylogenies of enzymes of the Embden
... accepted. For example, others have argued that hyperthermophiles may have evolved from mesophilic ancestors, based on comparison of the enzyme reverse gyrase, which is found in all organisms with optimum temperatures over 70 °C (Forterre 1996). Furthermore, a hyperthermophilic origin of life is also ...
... accepted. For example, others have argued that hyperthermophiles may have evolved from mesophilic ancestors, based on comparison of the enzyme reverse gyrase, which is found in all organisms with optimum temperatures over 70 °C (Forterre 1996). Furthermore, a hyperthermophilic origin of life is also ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.