Introduction to the BLAST Suite and BLASTN
... Finally, all the alignments between the query and the database subjects, or “high-scoring subject pairs” (HSPs), are ranked based on length and significance. The best hits are kept and shown to you in the forms of a graphic, a table, and alignments between the query and the hits. ...
... Finally, all the alignments between the query and the database subjects, or “high-scoring subject pairs” (HSPs), are ranked based on length and significance. The best hits are kept and shown to you in the forms of a graphic, a table, and alignments between the query and the hits. ...
Genome Biology - Department of Computer Science and
... recruitment of TFs [3, 4, 21]. Both functions directly relate to transcription regulation by TFs. Genomic mapping of chromatin modifications in yeast using ChIP-chip has provided the opportunity to investigate their underlying relationships with TFBSs [22, 23]. Many chromatin modifications have been ...
... recruitment of TFs [3, 4, 21]. Both functions directly relate to transcription regulation by TFs. Genomic mapping of chromatin modifications in yeast using ChIP-chip has provided the opportunity to investigate their underlying relationships with TFBSs [22, 23]. Many chromatin modifications have been ...
Alternatively Spliced Genes
... 3 orientation of U4 and U4atac is from right to left, and that of U1, U11, U2, U12, and U5snRNAs is from left to right. The RNA helices are indicated by Roman numerals, and nucleotide positions by Arabic numerals. The shaded nucleotides are binding sites for Sm proteins, and regions marked with bla ...
... 3 orientation of U4 and U4atac is from right to left, and that of U1, U11, U2, U12, and U5snRNAs is from left to right. The RNA helices are indicated by Roman numerals, and nucleotide positions by Arabic numerals. The shaded nucleotides are binding sites for Sm proteins, and regions marked with bla ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... late gestation (>20 weeks). The two hallmark symptoms are hypertension and proteinuria, complicating at least 5% of pregnancies and are usually resolved upon delivery of the placenta (Lain and Roberts, 2002). Although preeclampsia is a leading cause of maternal death and a major contributor to mater ...
... late gestation (>20 weeks). The two hallmark symptoms are hypertension and proteinuria, complicating at least 5% of pregnancies and are usually resolved upon delivery of the placenta (Lain and Roberts, 2002). Although preeclampsia is a leading cause of maternal death and a major contributor to mater ...
Introduction to GO Annotation
... Extracting Information from a paper Sample text from PMID: 12374299 In this study, we report the isolation and molecular characterization of the B. napus PERK1 cDNA, that is predicted to encode a novel receptor-like kinase. We have shown that like other plant RLKs, the kinase domain of PERK1 has se ...
... Extracting Information from a paper Sample text from PMID: 12374299 In this study, we report the isolation and molecular characterization of the B. napus PERK1 cDNA, that is predicted to encode a novel receptor-like kinase. We have shown that like other plant RLKs, the kinase domain of PERK1 has se ...
Single Nucleotide Polymorphism (SNP) of the Endothelial Nitric
... normal serum follicle-stimulating hormone, luteinizing hormone, testosterone, estradiol, and prolactin levels. There was no evidence of anatomic abnormalities of the genital tract, including varicocele (excluded by scrotal Doppler sonography). There was no history of cryptorchidism, testicular torsi ...
... normal serum follicle-stimulating hormone, luteinizing hormone, testosterone, estradiol, and prolactin levels. There was no evidence of anatomic abnormalities of the genital tract, including varicocele (excluded by scrotal Doppler sonography). There was no history of cryptorchidism, testicular torsi ...
Educator Materials
... patterns of inheritance, they see dominant and recessive symbols for alleles (A, a, respectively). Biologists also use symbols that do not denote dominance (for example, A1 and A2, A1 and A2, or A1 and A2 for two alleles of the gene A). Alleles are also sometimes represented using a nucleotide that ...
... patterns of inheritance, they see dominant and recessive symbols for alleles (A, a, respectively). Biologists also use symbols that do not denote dominance (for example, A1 and A2, A1 and A2, or A1 and A2 for two alleles of the gene A). Alleles are also sometimes represented using a nucleotide that ...
Compound heterozygosity of novel missense
... Mutations associated with hereditary combined VKD coagulation factor deficiency are rare. The carboxylase is encoded by a single gene,29 and only 3 naturally occurring missense mutations have previously been identified: Leu394Arg,10 which is impaired in both Glu binding and propeptide binding,30 Trp ...
... Mutations associated with hereditary combined VKD coagulation factor deficiency are rare. The carboxylase is encoded by a single gene,29 and only 3 naturally occurring missense mutations have previously been identified: Leu394Arg,10 which is impaired in both Glu binding and propeptide binding,30 Trp ...
Toward a therapy for mitochondrial disease
... Xenogenes, single-peptide enzymes derived from yeast or low eukaryotes, have been used to bypass the block of the RC due to defects in specific complexes in cellular and Drosophila models. The rationale for using these non-proton-pumping enzymes is that they should re-establish the electron flow, thus ...
... Xenogenes, single-peptide enzymes derived from yeast or low eukaryotes, have been used to bypass the block of the RC due to defects in specific complexes in cellular and Drosophila models. The rationale for using these non-proton-pumping enzymes is that they should re-establish the electron flow, thus ...
Exceptionally high levels of recombination
... higher recombination rate in the bee genome has been documented in several mammalian species as well (Yu et al. 2001; Jensen-Seaman et al. 2004), with the exception of some sequence-specific repeats. Simple repeats could mechanistically facilitate recombination, or, alternatively, recombination itse ...
... higher recombination rate in the bee genome has been documented in several mammalian species as well (Yu et al. 2001; Jensen-Seaman et al. 2004), with the exception of some sequence-specific repeats. Simple repeats could mechanistically facilitate recombination, or, alternatively, recombination itse ...
1 FRQ-interacting RNA Helicase (FRH) Mediates Negative and
... for the feedback loop, and the model of the core oscillator as a single negative feedback loop (Crosthwaite et al. 1997). Later work established that FRQ actually binds to and inhibits the activity of its own transcription activators, the WCC (Cheng et al. 2001a; Denault et al. 2001; Froehlich et a ...
... for the feedback loop, and the model of the core oscillator as a single negative feedback loop (Crosthwaite et al. 1997). Later work established that FRQ actually binds to and inhibits the activity of its own transcription activators, the WCC (Cheng et al. 2001a; Denault et al. 2001; Froehlich et a ...
The Breast Cancer Polygene and Longevity Genes: The Implications
... Levels of σR at which adverse selection occurs, i.e. the (−3,0) subpopulation no longer purchase at the rate offered by the insurer. Figures in bold correspond to parameterisations lower than in the fitted model of Antoniou et al. (2002). Figures underlined produce relative risk statistics that resu ...
... Levels of σR at which adverse selection occurs, i.e. the (−3,0) subpopulation no longer purchase at the rate offered by the insurer. Figures in bold correspond to parameterisations lower than in the fitted model of Antoniou et al. (2002). Figures underlined produce relative risk statistics that resu ...
Gene Section MUC4 (mucin 4, cell surface associated) in Oncology and Haematology
... positioned in introns 3, 4, and 5 respectively. Theses sequences present also VNTR polymorphism. Various SNPs are reported for MUC4 coding sequence; however, either VNTR or SNP polymorphism have been associated with specific physiological condition or disease. ...
... positioned in introns 3, 4, and 5 respectively. Theses sequences present also VNTR polymorphism. Various SNPs are reported for MUC4 coding sequence; however, either VNTR or SNP polymorphism have been associated with specific physiological condition or disease. ...
Pseudouridine at position 55 in tRNA controls the contents of other
... chaperone activity of TruB, which was previously hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these m ...
... chaperone activity of TruB, which was previously hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these m ...
Pet_SUMO manual
... Genotype: F- ompT hsdSB (rB-mB-) gal dcm (DE3) The DE3 designation means this strain contains the lambda DE3 lysogen which carries the gene for T7 RNA polymerase under the control of the lacUV5 promoter. IPTG is required to induce expression of the T7 RNA polymerase. The strain is an E. coli B/r str ...
... Genotype: F- ompT hsdSB (rB-mB-) gal dcm (DE3) The DE3 designation means this strain contains the lambda DE3 lysogen which carries the gene for T7 RNA polymerase under the control of the lacUV5 promoter. IPTG is required to induce expression of the T7 RNA polymerase. The strain is an E. coli B/r str ...
A physiological overview of the genetics of flowering time control
... these plants is the reaching of a threshold size, although this threshold may vary greatly amongst species and ecotypes (Lacey, 1986; Wesselingh et al., 1993). This conclusion is in line with physiological observations showing that partial or complete removal of foliage, i.e. plant trimming, may dec ...
... these plants is the reaching of a threshold size, although this threshold may vary greatly amongst species and ecotypes (Lacey, 1986; Wesselingh et al., 1993). This conclusion is in line with physiological observations showing that partial or complete removal of foliage, i.e. plant trimming, may dec ...
Age-related macular degeneration: a perspective on genetic studies
... the presence of increase amyloid b-peptides deposition in cerebral cortex.39 The role of ApoE has also been investigated extensively to understand the aetiology of AMD. This polymorphic protein plays an important role in lipid metabolism and central nervous system lipid homeostasis and the presence ...
... the presence of increase amyloid b-peptides deposition in cerebral cortex.39 The role of ApoE has also been investigated extensively to understand the aetiology of AMD. This polymorphic protein plays an important role in lipid metabolism and central nervous system lipid homeostasis and the presence ...
Laboratory testing of CYP2D6 alleles in relation to tamoxifen therapy
... the genotype test report about how a given phenotype prediction has been arrived at. There is only limited accuracy in calling an allele normal/ functional on the basis of the nucleotide sequence detected. This is because genotyping is not comprehensive enough to identify all currently known sequenc ...
... the genotype test report about how a given phenotype prediction has been arrived at. There is only limited accuracy in calling an allele normal/ functional on the basis of the nucleotide sequence detected. This is because genotyping is not comprehensive enough to identify all currently known sequenc ...
protein 2 gene: study of a cohort of Israeli patients - MRC
... From the genetic standpoint, RTT is an X-linked dominant disorder caused by defects in the MECP2 gene on chromosome Xq28. MECP2 mutations were detected in .85% of patients with classic RTT, most of which (about 70%) involve CRT transitions at specific CpG hot spots in exons 3 and 4; an additional 10 ...
... From the genetic standpoint, RTT is an X-linked dominant disorder caused by defects in the MECP2 gene on chromosome Xq28. MECP2 mutations were detected in .85% of patients with classic RTT, most of which (about 70%) involve CRT transitions at specific CpG hot spots in exons 3 and 4; an additional 10 ...
Genotype C of hepatitis B virus can be classified into at least two
... detected in Asia could be classified into at least two subgroups, which we named HBV/C1 and HBV/C2. Notably, HBV/C1 was found only in southeast Asia including Vietnam, Myanmar and Thailand, while HBV/C2 was found in Far East Asia including Japan, Korea and China. By means of phylogenetic analysis in ...
... detected in Asia could be classified into at least two subgroups, which we named HBV/C1 and HBV/C2. Notably, HBV/C1 was found only in southeast Asia including Vietnam, Myanmar and Thailand, while HBV/C2 was found in Far East Asia including Japan, Korea and China. By means of phylogenetic analysis in ...
That have been aligned so that homologous residues are arranged
... Amino-acid sequence alignments are easier to carry out and less ambiguous than nucleotide alignments. A typical approach is to carry out the alignment at the aminoacid level and use it to generate a corresponding nucleotide sequence alignment, which can then be analyzed as usual. Numerous computer p ...
... Amino-acid sequence alignments are easier to carry out and less ambiguous than nucleotide alignments. A typical approach is to carry out the alignment at the aminoacid level and use it to generate a corresponding nucleotide sequence alignment, which can then be analyzed as usual. Numerous computer p ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.