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Long noncoding RNA found to quell inflammation
Long noncoding RNA found to quell inflammation

... 14 July 2016, by Jim Fessenden A long non-coding RNA (lincRNA) - called lincRNA- this brake, and the pro-inflammatory response is EPS - responsible for regulating innate immunity initiated. Mice that were lacking lincRNA-EPS has been identified by a team of scientists at the exhibited increased leve ...
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Immune Response

...  These cause increased blood flow (which causes swelling) to get more white blood cells  WBCs attack pathogens  Lymph nodes may also swell with fluid when they fight infection ...
Molecular Immunology
Molecular Immunology

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adaptive immunity

... Circulating B cells which have not been exposed to the antigen  naive B cells When BCR binds to the antigen, the antigen is internalised by the B cell and presented to the T cells ...
Immunity Student Outline
Immunity Student Outline

... 2.28 The student is able to use representations or models to analyze quantitatively and qualitatively the effects of disruptions to dynamic homeostasis in biological systems. 2.29 The student can create representations and models to describe immune responses. 2.30 The students can create representat ...
Immunity Questions
Immunity Questions

... 7. Describe the differences between the antigens that B cell receptors and antibodies recognize, and the antigens that T cell receptors on cytotoxic T cells and helper T cells recognize. 8. Describe the differences between the humoral immune response and the cell-mediate immune response. 9. Describe ...
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... ...
Immunity Review Questions
Immunity Review Questions

Immune Checkpoint Blockade in Cancer Therapy: New Insights and
Immune Checkpoint Blockade in Cancer Therapy: New Insights and

... The existence of multiple non-redundant inhibitory pathways that limit T cell responses offers novel strategies for mobilizing the immune system to attack cancer cells. The best characterized of these immune checkpoints is CTLA-4, which inhibits T cell proliferation by interfering with the interacti ...
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Ways that PBMC Isolation Aids Immunology Research

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Chapter 21 - Fundamentals of Microbiology

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... 2. Name 3 different types of barriers (mechanical, chemical, and microbial) that protect us from pathogens and list the key features for each category. 3. A dendritic cell phagocytoses a gram-negative bacteria. Which PAMP(s) may be detected? Which innate immune receptor will be detecting the PAMP(s) ...
Cell Signalling and communication between cells.
Cell Signalling and communication between cells.

... • Pathogens carry an antigen on its cell surface, they act as markers, they enable it to be detected by our body cells, as a ‘foreign cell’. Our own cells also carry antigens, but they are recognised as ‘self’. In order to avoid destroying any ‘self’ cells, the immune system will contain no cells w ...
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Unit #11: Animal Anatomy and Physiology- Immune

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Immune System Performances

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... non-antibody-producing lymphocytes which are also produced in the bone marrow but sensitized in the thymus and constitute the basis of cell-mediated immunity. ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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