Title Nanofiltration and reverse osmosis surface topographical
... The use of surface roughness as a parameter is usually quantified as the average roughness and root mean squared roughness. However, quantifying membrane topography in the presence of surface topographical heterogeneities (redefined as surface defects throughout this study) can be challenging [21], ...
... The use of surface roughness as a parameter is usually quantified as the average roughness and root mean squared roughness. However, quantifying membrane topography in the presence of surface topographical heterogeneities (redefined as surface defects throughout this study) can be challenging [21], ...
A Nascent Membrane Protein Is Located Adjacent to ER Membrane
... bilayer and is released into the lumen of the ER (Walter and Lingappa, 1986). In contrast, the nonpolar transmembrane segments of membrane proteins (also termed "stop-transfer" sequences; Blobel, 1980) do not pass through the bilayer, but are integrated into the membrane. The stop-transfer sequence ...
... bilayer and is released into the lumen of the ER (Walter and Lingappa, 1986). In contrast, the nonpolar transmembrane segments of membrane proteins (also termed "stop-transfer" sequences; Blobel, 1980) do not pass through the bilayer, but are integrated into the membrane. The stop-transfer sequence ...
A Nascent Membrane Protein Is Located Adjacent to
... bilayer and is released into the lumen of the ER (Walter and Lingappa, 1986). In contrast, the nonpolar transmembrane segments of membrane proteins (also termed "stop-transfer" sequences; Blobel, 1980) do not pass through the bilayer, but are integrated into the membrane. The stop-transfer sequence ...
... bilayer and is released into the lumen of the ER (Walter and Lingappa, 1986). In contrast, the nonpolar transmembrane segments of membrane proteins (also termed "stop-transfer" sequences; Blobel, 1980) do not pass through the bilayer, but are integrated into the membrane. The stop-transfer sequence ...
Dual-topology membrane proteins Escherichia coli Susanna Seppälä
... compartments with specialized functions (organelles), and multicellular organisms are, simply put, large conglomerates of specialized, yet discrete, cells. The generation and maintenance of intracellular and organellar disparity is largely managed by membrane proteins that permit a controlled, conti ...
... compartments with specialized functions (organelles), and multicellular organisms are, simply put, large conglomerates of specialized, yet discrete, cells. The generation and maintenance of intracellular and organellar disparity is largely managed by membrane proteins that permit a controlled, conti ...
Protection by chlorpromazine, albumin and bivalent cations against
... derivatives showed that their haemolytic potency correlated well with their corresponding ability to aggregate intramembrane particles and to reduce the rotational mobility of band 3 protein in erythrocyte membranes [13,14] and bacteriorhodopsin in lipid vesicles [15]. It was surmised that besides m ...
... derivatives showed that their haemolytic potency correlated well with their corresponding ability to aggregate intramembrane particles and to reduce the rotational mobility of band 3 protein in erythrocyte membranes [13,14] and bacteriorhodopsin in lipid vesicles [15]. It was surmised that besides m ...
Intracellular Redox Compartmentation and ROS
... location (Fig. 1). In this way, cells could have the capacity to modulate the tightness of coupling between H2O2 and signaling by modifying the metabolic pathway through which this ROS is metabolized (Fig. 1). Together with genetic and/or functional redundancy, this may be one reason why it has prov ...
... location (Fig. 1). In this way, cells could have the capacity to modulate the tightness of coupling between H2O2 and signaling by modifying the metabolic pathway through which this ROS is metabolized (Fig. 1). Together with genetic and/or functional redundancy, this may be one reason why it has prov ...
ref. #29 of the TIBS article
... obtained by determining the number of residues between a given reference residue at the end of the transmembrane helix (the first Gln after the poly-Leu stretch) and the glycosylation acceptor Asn needed to achieve half-maximal glycosylation (see Figure 2B). We have shown previously that the P2 doma ...
... obtained by determining the number of residues between a given reference residue at the end of the transmembrane helix (the first Gln after the poly-Leu stretch) and the glycosylation acceptor Asn needed to achieve half-maximal glycosylation (see Figure 2B). We have shown previously that the P2 doma ...
CONDUCTION INTRODUCTION
... conduction. By this we mean that the action potential is conducted with great speed between nodes (due to greatly decreased time constant for conduction) and pauses to regenerate itself only at the nodes of Ranvier. The nodes of Ranvier occur about every mm which is a good deal less than the length ...
... conduction. By this we mean that the action potential is conducted with great speed between nodes (due to greatly decreased time constant for conduction) and pauses to regenerate itself only at the nodes of Ranvier. The nodes of Ranvier occur about every mm which is a good deal less than the length ...
fulltext - DiVA Portal
... functionally very important part of every cell. The membrane forms not only a barrier that seal out the cell’s external environment and so defines its boundary, but also mediates the selective exchange of information and substances. Furthermore, membranes are the sites where key steps of many vital ...
... functionally very important part of every cell. The membrane forms not only a barrier that seal out the cell’s external environment and so defines its boundary, but also mediates the selective exchange of information and substances. Furthermore, membranes are the sites where key steps of many vital ...
Document
... I. Intracellular Vesicular Traffic (chapter 13, Alberts) A. Two pathways: Biosynthetic secretory and endocytic, Fig. 13-1 B. The process of transport between all parts of the pathway is identical, vesicular transport, Fig. 13-2. C. Experimental Methods for studying vesicular transport 1. Cell free s ...
... I. Intracellular Vesicular Traffic (chapter 13, Alberts) A. Two pathways: Biosynthetic secretory and endocytic, Fig. 13-1 B. The process of transport between all parts of the pathway is identical, vesicular transport, Fig. 13-2. C. Experimental Methods for studying vesicular transport 1. Cell free s ...
Diacylglycerol kinases - University of Toronto Mississauga
... selectivity of DGK C1 domains for authentic DAG, unlike other C1 domains such as those in PKCs which appear to be more promiscuous. Houssa and van Blitterswijk [28] noted that in DGKs, the C1 domain closest to the catalytic domain is highly conserved, including an extended motif of 15 amino acids no ...
... selectivity of DGK C1 domains for authentic DAG, unlike other C1 domains such as those in PKCs which appear to be more promiscuous. Houssa and van Blitterswijk [28] noted that in DGKs, the C1 domain closest to the catalytic domain is highly conserved, including an extended motif of 15 amino acids no ...
Runions et al - Oxford Academic
... network. Because the ER is not visible prior to photoactivation of the PAGFP in its membrane, only about 75% of the cells that were targeted yielded analysable results. The other cells either had not been transformed with the CX-PAGFP construct or the ER was not in the focal plane before the scannin ...
... network. Because the ER is not visible prior to photoactivation of the PAGFP in its membrane, only about 75% of the cells that were targeted yielded analysable results. The other cells either had not been transformed with the CX-PAGFP construct or the ER was not in the focal plane before the scannin ...
Therapeutic approaches to Lysosomal Storage Disorders
... required for membrane fusion. SNARE proteins are classified as vesicle SNAREs (vSNAREs), located on the vesicles membrane, and target SNAREs (t-SNAREs), located on the membranes of target compartments. SNAREs may vary in size and composition, but they all share a 60-70 amino acid cytosolic domain ( ...
... required for membrane fusion. SNARE proteins are classified as vesicle SNAREs (vSNAREs), located on the vesicles membrane, and target SNAREs (t-SNAREs), located on the membranes of target compartments. SNAREs may vary in size and composition, but they all share a 60-70 amino acid cytosolic domain ( ...
Photoactivation of GFP reveals protein dynamics within the
... network. Because the ER is not visible prior to photoactivation of the PAGFP in its membrane, only about 75% of the cells that were targeted yielded analysable results. The other cells either had not been transformed with the CX-PAGFP construct or the ER was not in the focal plane before the scannin ...
... network. Because the ER is not visible prior to photoactivation of the PAGFP in its membrane, only about 75% of the cells that were targeted yielded analysable results. The other cells either had not been transformed with the CX-PAGFP construct or the ER was not in the focal plane before the scannin ...
REVIEWS
... membrane surface1,2. Moreover, upon stimulation of cell surface receptors, numerous signalling proteins are transiently recruited to specific locations in plasma (and other) membranes, where they exert their functions (such as lipid modification or activation of small GTPases) or become effectively ...
... membrane surface1,2. Moreover, upon stimulation of cell surface receptors, numerous signalling proteins are transiently recruited to specific locations in plasma (and other) membranes, where they exert their functions (such as lipid modification or activation of small GTPases) or become effectively ...
Full-Text PDF
... The folding, and therefore function, of membrane proteins is known to be heavily influenced by the biophysical properties of the membrane in which they are embedded [25–31], which are in turn determined by the lipid composition of the membrane [32]. The choice of protocell membrane is key, not simpl ...
... The folding, and therefore function, of membrane proteins is known to be heavily influenced by the biophysical properties of the membrane in which they are embedded [25–31], which are in turn determined by the lipid composition of the membrane [32]. The choice of protocell membrane is key, not simpl ...
Vegetable lipid sources in vitro biosyntheis of triacylglycerols and
... Despite the good growth performance of several fish species when dietary fish oil is partly replaced by vegetable oils, recent studies have reported several types of intestinal morphological alterations in cultured fish fed high contents of vegetable lipid sources. However, the physiological process ...
... Despite the good growth performance of several fish species when dietary fish oil is partly replaced by vegetable oils, recent studies have reported several types of intestinal morphological alterations in cultured fish fed high contents of vegetable lipid sources. However, the physiological process ...
Single-channel electrophysiology reveals a distinct and uniform
... The highest number of conductance steps (N = 4435) was recorded at +80 mV due to voltage-dependency and a higher number of traces recorded at this voltage. Thus, detailed quantitative analysis of the distribution of conductance steps and conductance levels was performed for this voltage (Fig. 3A, B) ...
... The highest number of conductance steps (N = 4435) was recorded at +80 mV due to voltage-dependency and a higher number of traces recorded at this voltage. Thus, detailed quantitative analysis of the distribution of conductance steps and conductance levels was performed for this voltage (Fig. 3A, B) ...
At the border: the plasma membrane–cell wall continuum
... that the CSCs are delivered to DRM microdomains. Lipid analysis revealed that DRMs are enriched in sterols and sphingolipids (Borner et al., 2005; Lefebvre et al., 2007). Sterols are one of the most important regulators of plasma membrane microdomain maintenance (Zauber et al., 2014). Perturbations ...
... that the CSCs are delivered to DRM microdomains. Lipid analysis revealed that DRMs are enriched in sterols and sphingolipids (Borner et al., 2005; Lefebvre et al., 2007). Sterols are one of the most important regulators of plasma membrane microdomain maintenance (Zauber et al., 2014). Perturbations ...
At the border: the plasma membrane–cell wall
... that the CSCs are delivered to DRM microdomains. Lipid analysis revealed that DRMs are enriched in sterols and sphingolipids (Borner et al., 2005; Lefebvre et al., 2007). Sterols are one of the most important regulators of plasma membrane microdomain maintenance (Zauber et al., 2014). Perturbations ...
... that the CSCs are delivered to DRM microdomains. Lipid analysis revealed that DRMs are enriched in sterols and sphingolipids (Borner et al., 2005; Lefebvre et al., 2007). Sterols are one of the most important regulators of plasma membrane microdomain maintenance (Zauber et al., 2014). Perturbations ...
Structural and Functional Comparisons of Retroviral Envelope
... view of gp41 (and, thus, Env as a whole) as a type I membrane protein, with an extracellular N-terminus, a single MSD and an approximately 150 amino acid-long cytoplasmic C-terminal tail (CTT) [2]. More recent studies, however, indicate that the CTT topology may be more dynamic and complex than prev ...
... view of gp41 (and, thus, Env as a whole) as a type I membrane protein, with an extracellular N-terminus, a single MSD and an approximately 150 amino acid-long cytoplasmic C-terminal tail (CTT) [2]. More recent studies, however, indicate that the CTT topology may be more dynamic and complex than prev ...
Det här verket är upphovrättskyddat enligt Lagen (1960
... cytosis. The best known type of endocytosis in the thyroid is macropinocytosis. Studies with transmission (10, 28, 38, 39, 40, 42, 45) and scanning (1, 25, 56) electron microscopy have re vealed the structural details of this process. The first well defined step in macropinocytosis is the protrusi ...
... cytosis. The best known type of endocytosis in the thyroid is macropinocytosis. Studies with transmission (10, 28, 38, 39, 40, 42, 45) and scanning (1, 25, 56) electron microscopy have re vealed the structural details of this process. The first well defined step in macropinocytosis is the protrusi ...
Eph receptor signaling in C. elegans
... manifest as incompletely penetrant head and tail abnormalities. While partial redundancy among pathways governing these developmental processes is one explanation for variability and incomplete penetrance of the mutant alleles, there may also be another (not necessarily mutually exclusive) answer. “ ...
... manifest as incompletely penetrant head and tail abnormalities. While partial redundancy among pathways governing these developmental processes is one explanation for variability and incomplete penetrance of the mutant alleles, there may also be another (not necessarily mutually exclusive) answer. “ ...
Symposium 74_Evolution: The Molecular Landscape
... coefficient of ribose is fivefold larger than that of its diastereomers (Sacerdote and Szostak 2005). Recent molecular dynamics simulations suggest that the greater permeability of ribose reflects its internally satisfied Hbonding interactions and consequently less extensive water–solute interaction ...
... coefficient of ribose is fivefold larger than that of its diastereomers (Sacerdote and Szostak 2005). Recent molecular dynamics simulations suggest that the greater permeability of ribose reflects its internally satisfied Hbonding interactions and consequently less extensive water–solute interaction ...
Lipid raft
The plasma membranes of cells contain combinations of glycosphingolipids and protein receptors organized in glycolipoprotein microdomains termed lipid rafts. These specialized membrane microdomains compartmentalize cellular processes by serving as organizing centers for the assembly of signaling molecules, influencing membrane fluidity and membrane protein trafficking, and regulating neurotransmission and receptor trafficking. Lipid rafts are more ordered and tightly packed than the surrounding bilayer, but float freely in the membrane bilayer. Although more common in plasma membrane, lipid rafts have also been reported in other parts of the cell, such as Golgi and lysosomes.