Exocytosis acts as a modulator of the ILT4
... The myelomonoblast PLB-985 cell line is considered as an appropriate model to generate neutrophil-like cells upon differentiation with Dimethylformamide (DMF) or Dimethylsulfoxide (DMSO) treatment. As shown in Fig. 1C, most of undifferentiated PLB-985 cells did not express ILT4 on their surface. How ...
... The myelomonoblast PLB-985 cell line is considered as an appropriate model to generate neutrophil-like cells upon differentiation with Dimethylformamide (DMF) or Dimethylsulfoxide (DMSO) treatment. As shown in Fig. 1C, most of undifferentiated PLB-985 cells did not express ILT4 on their surface. How ...
Physiology of ionophore transport of potassium and sodium
... carbonyl oxygens coordinated to Na+ (av bond length 2.65Å) (Varma et al., 2008, 2011; Kholmurodov et al., 2010) which is similar to the crystal structure which has 3 bonds to the carbonyl oxygens and one water molecule hydrogen bonded to the Na+. There are several likely conformations of similar ene ...
... carbonyl oxygens coordinated to Na+ (av bond length 2.65Å) (Varma et al., 2008, 2011; Kholmurodov et al., 2010) which is similar to the crystal structure which has 3 bonds to the carbonyl oxygens and one water molecule hydrogen bonded to the Na+. There are several likely conformations of similar ene ...
The Vps13p–Cdc31p complex is directly required for TGN late
... TGN–PVC transport is completely defective when both donor and acceptor MSSs lack Vps13p or when acceptor membranes alone lack Vps13p. However, a partial reaction can occur when acceptor membranes contained Vps13p, indicating a crucial role for Vps13p at the PVC in TGN–PVC transport. The requirement ...
... TGN–PVC transport is completely defective when both donor and acceptor MSSs lack Vps13p or when acceptor membranes alone lack Vps13p. However, a partial reaction can occur when acceptor membranes contained Vps13p, indicating a crucial role for Vps13p at the PVC in TGN–PVC transport. The requirement ...
Volume 1, Issue 1 - The Pharma Innovation
... section of a living cell membrane which consists largely of phospholipids. As you can see, the phospholipid molecules have arranged themselves to form a membrane so that oil droplets cannot penetrate the cell membrane because they would be repelled by the wall of hydrophilic heads. In like manner, n ...
... section of a living cell membrane which consists largely of phospholipids. As you can see, the phospholipid molecules have arranged themselves to form a membrane so that oil droplets cannot penetrate the cell membrane because they would be repelled by the wall of hydrophilic heads. In like manner, n ...
Brassinosteroid Signal Transduction from Receptor Kinases to
... of the leucine-rich repeat-receptor-like kinase (LRR-RLK) family in Arabidopsis (79), and BR INSENSITIVE 2 (BIN2) encodes one of the 10 glycogen synthase kinase 3 (GSK3)-like kinases of Arabidopsis (50). Sensitized genetic screens using the BR biosynthetic inhibitor brassinazole (BRZ) or weak allele ...
... of the leucine-rich repeat-receptor-like kinase (LRR-RLK) family in Arabidopsis (79), and BR INSENSITIVE 2 (BIN2) encodes one of the 10 glycogen synthase kinase 3 (GSK3)-like kinases of Arabidopsis (50). Sensitized genetic screens using the BR biosynthetic inhibitor brassinazole (BRZ) or weak allele ...
Effects of phytanic acid on the vitamin E status, lipid composition and
... fatty acid content of the retina have been reported in two patients with ARD [5]. Two principal hypotheses (the molecular distortion hypothesis and the anti-metabolite hypothesis) have been proposed to explain the pathogenesis of ARD [6–8]. The molecular distortion hypothesis proposes that infiltrat ...
... fatty acid content of the retina have been reported in two patients with ARD [5]. Two principal hypotheses (the molecular distortion hypothesis and the anti-metabolite hypothesis) have been proposed to explain the pathogenesis of ARD [6–8]. The molecular distortion hypothesis proposes that infiltrat ...
Structural Sterols Are Involved in Both the Initiation and Tip Growth
... chemical structure of sterols determine phase separation, positive or negative curvature, and even vesicle pinching off from the sterol-rich phase (Bacia et al., 2005). Phospholipids interact with sterols via van der Waals and hydrophobic forces (Bessoule and Moreau, 2004). The most important form o ...
... chemical structure of sterols determine phase separation, positive or negative curvature, and even vesicle pinching off from the sterol-rich phase (Bacia et al., 2005). Phospholipids interact with sterols via van der Waals and hydrophobic forces (Bessoule and Moreau, 2004). The most important form o ...
A painful TR(i)P to lysosomes
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
A painful TR(i)P to lysosomes
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
A painful TR(i)P to lysosomes
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
A painful TR(i)P to lysosomes
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
... membrane trafficking of TRPA1 lysosomes is not or differentially regulated by general trafficking cues (Fig. 1). No autophagic defects or lysosomal dysfunction have been reported for TRPA1 KO mice. A provocative speculation is that peripherally localized TRPA1 lysosomes are selectively connected wi ...
2. Fredriksson, R., et al., The G-protein
... Structural information of GPCRs is vital to understand how these signaling molecules carry out their function and also for drug development. However, little is known about the structural basis of GPCR function in spite of extensive studies in both academic and industrial institutions [34-36]. The mo ...
... Structural information of GPCRs is vital to understand how these signaling molecules carry out their function and also for drug development. However, little is known about the structural basis of GPCR function in spite of extensive studies in both academic and industrial institutions [34-36]. The mo ...
The p101 subunit of PI3Kγ restores activation by Gβ mutants
... signals into the principle product PtdIns(3,4,5)P3 in order to control a plethora of fundamental cellular responses, including proliferation, differentiation, growth and chemotaxis [1–8]. On the basis of their structural features and modes of regulation, class I PI3Ks have been grouped into the clas ...
... signals into the principle product PtdIns(3,4,5)P3 in order to control a plethora of fundamental cellular responses, including proliferation, differentiation, growth and chemotaxis [1–8]. On the basis of their structural features and modes of regulation, class I PI3Ks have been grouped into the clas ...
The Golgi Apparatus
... 1. Labeling of lysosomal enzymes, in cis area 2. Transport from cis-face toward trans-face, and maturation 3. Sorting and budding, in trans area, as primary lysosomes 4. Fusion with late endosomes or already existing secondary lysosome ...
... 1. Labeling of lysosomal enzymes, in cis area 2. Transport from cis-face toward trans-face, and maturation 3. Sorting and budding, in trans area, as primary lysosomes 4. Fusion with late endosomes or already existing secondary lysosome ...
Stockholm University
... the disulfide bond formation between them and aids the folding process of insulin [3, 4]. Since the discovery, several biological effects of C-peptide have been demonstrated [5– ...
... the disulfide bond formation between them and aids the folding process of insulin [3, 4]. Since the discovery, several biological effects of C-peptide have been demonstrated [5– ...
Linköping University Post Print
... death machinery. Lysosomes, which were first described by de Duve and colleagues in 1955 [1], are acidic, single-membrane bound organelles that are present in all eukaryotic cells [2]. The primary function of lysosomes is degradation of macromolecules, and for this purpose, lysosomes are filled with ...
... death machinery. Lysosomes, which were first described by de Duve and colleagues in 1955 [1], are acidic, single-membrane bound organelles that are present in all eukaryotic cells [2]. The primary function of lysosomes is degradation of macromolecules, and for this purpose, lysosomes are filled with ...
Lipid interaction of the C terminus and association of the
... (14). HSP is a neurodegenerative disease caused by the shortening of the axons in corticospinal motor neurons, leading to progressive spasticity and weakness of the lower limbs. Yeast and plant cells do not possess ATLs, but similar GTPases—Sey1p in Saccharomyces cerevisiae and Root Hair Defective 3 ...
... (14). HSP is a neurodegenerative disease caused by the shortening of the axons in corticospinal motor neurons, leading to progressive spasticity and weakness of the lower limbs. Yeast and plant cells do not possess ATLs, but similar GTPases—Sey1p in Saccharomyces cerevisiae and Root Hair Defective 3 ...
REVIEW - The Journal of Cell Biology
... accounts for ~ 2 5 - 3 0 % of the total thylakoid membrane proteins, and it consists of at least two integral polypeptides (90) of similar molecular weights (cf. reference 4). Several peripheral membrane proteins including ferredoxin, ferredoxinNADP reductase (cf. reference 19), plastocyanin (53, 61 ...
... accounts for ~ 2 5 - 3 0 % of the total thylakoid membrane proteins, and it consists of at least two integral polypeptides (90) of similar molecular weights (cf. reference 4). Several peripheral membrane proteins including ferredoxin, ferredoxinNADP reductase (cf. reference 19), plastocyanin (53, 61 ...
ref. #28 of the TIBS article
... While it is generally accepted that the overall hydrophobicity provides the primary driving force for the integration of transmembrane a-helices (TMHs) into biological membranes (von Heijne, 1997), very little is known about the detailed molecular interactions that control the precise positioning of ...
... While it is generally accepted that the overall hydrophobicity provides the primary driving force for the integration of transmembrane a-helices (TMHs) into biological membranes (von Heijne, 1997), very little is known about the detailed molecular interactions that control the precise positioning of ...
PHOSPHOLIPIDS AND BIOMEMBRANES L. L. M. VAN DEENEN
... de Jong49, 66.67 and his school pictured models of the cell membrane, involving a tncomplex system between phospholipids, proteins and cations. Many other approaches further endorsed the importance of phospholipids for attaining the physical and chemical arrangements required to give the bio-interfa ...
... de Jong49, 66.67 and his school pictured models of the cell membrane, involving a tncomplex system between phospholipids, proteins and cations. Many other approaches further endorsed the importance of phospholipids for attaining the physical and chemical arrangements required to give the bio-interfa ...
Annexins: multifunctional components of growth and adaptation
... structural requirement for actin binding is more complex. As yet annexins from two of the most studied species, Arabidopsis and Medicago, have not been tested for F-actin binding, although Arabidopsis sequences contain a full or partially conserved F-actin-binding motif (Clark et al., 2001). The fun ...
... structural requirement for actin binding is more complex. As yet annexins from two of the most studied species, Arabidopsis and Medicago, have not been tested for F-actin binding, although Arabidopsis sequences contain a full or partially conserved F-actin-binding motif (Clark et al., 2001). The fun ...
PROPERTIES OF ANTI-MYCOLIC ACID ANTIBODIES IN HUMAN TUBERCULOSIS PATIENTS Master of Science
... Antigen presentation to T cells. ...
... Antigen presentation to T cells. ...
Mitofilin complexes: conserved organizers of mitochondrial
... contact sites was first proposed by Hackenbrock 1968. In this study, isolated mitochondria were diluted into a buffer of high osmolarity, which leads to the extrusion of water and shrinking of the mitochondrial matrix compartment. Electron microscopy images showed that, under these conditions, the i ...
... contact sites was first proposed by Hackenbrock 1968. In this study, isolated mitochondria were diluted into a buffer of high osmolarity, which leads to the extrusion of water and shrinking of the mitochondrial matrix compartment. Electron microscopy images showed that, under these conditions, the i ...
Neutrophils injure cultured skeletal myotubes
... microscopy were performed on several control cultures (myotubes only) and on cultures containing both neutrophils (nonin vitro-stimulated) and myotubes (E:T ratio of 5). Because of the severity of the neutrophil-mediated myotube injury at E:T ratios greater than five, an E:T ratio of five was used f ...
... microscopy were performed on several control cultures (myotubes only) and on cultures containing both neutrophils (nonin vitro-stimulated) and myotubes (E:T ratio of 5). Because of the severity of the neutrophil-mediated myotube injury at E:T ratios greater than five, an E:T ratio of five was used f ...
Lipid raft
The plasma membranes of cells contain combinations of glycosphingolipids and protein receptors organized in glycolipoprotein microdomains termed lipid rafts. These specialized membrane microdomains compartmentalize cellular processes by serving as organizing centers for the assembly of signaling molecules, influencing membrane fluidity and membrane protein trafficking, and regulating neurotransmission and receptor trafficking. Lipid rafts are more ordered and tightly packed than the surrounding bilayer, but float freely in the membrane bilayer. Although more common in plasma membrane, lipid rafts have also been reported in other parts of the cell, such as Golgi and lysosomes.