Interactions of liposomes and lipid-based carrier systems with blood
... clearance properties in the biological milieu. ...
... clearance properties in the biological milieu. ...
Heat Shock Responses for Understanding Diseases of
... of each stress can protect cells against subsequent administration of other lethal stresses. This phenomenon, called cross-resistance, suggests that some kinds of stresses have common cellular processes. Recent results suggest that aberrant heat shock responses are associated with diseases including ...
... of each stress can protect cells against subsequent administration of other lethal stresses. This phenomenon, called cross-resistance, suggests that some kinds of stresses have common cellular processes. Recent results suggest that aberrant heat shock responses are associated with diseases including ...
VECTOR SYSTEMS XXVII.indd
... Our Bacillus megaterium kit is a new easy-to-handle system for stable protein expression with high yield. It is not only suited for industrial large scale protein production, but offers also an interesting alternative to the standard host E. coli. The kit comes with the E. coli/Bacillus megaterium s ...
... Our Bacillus megaterium kit is a new easy-to-handle system for stable protein expression with high yield. It is not only suited for industrial large scale protein production, but offers also an interesting alternative to the standard host E. coli. The kit comes with the E. coli/Bacillus megaterium s ...
LENS - Peshawar Medical College, Peshawar Dental College
... organized structure of lens, dense packing of crystalline. Avascularity, absence of pigments and optimal hydration. By act of accommodation it changes focusing power. Accommodation occurs by increasing the curvature of anterior surface thereby changing refractive power of lens. Light transmission ...
... organized structure of lens, dense packing of crystalline. Avascularity, absence of pigments and optimal hydration. By act of accommodation it changes focusing power. Accommodation occurs by increasing the curvature of anterior surface thereby changing refractive power of lens. Light transmission ...
Characterization of a novel phosphatidylinositol 3
... as novel zinc fingers that are present in a variety of proteins implicated in vesicular trafficking. These 70 residue domains are highly conserved between species and are named after the first four proteins (Fab1p, YOTB, Vac1p and EEA1) shown to contain them [1]. Although first identified in protein ...
... as novel zinc fingers that are present in a variety of proteins implicated in vesicular trafficking. These 70 residue domains are highly conserved between species and are named after the first four proteins (Fab1p, YOTB, Vac1p and EEA1) shown to contain them [1]. Although first identified in protein ...
ABCA3 Gene Mutations in Newborns with Fatal
... These included homozygous nonsense mutations in codons 106 and 1142, a homozygous frameshift mutation, and heterozygous insertion mutations and splice-site mutations. Seven missense mutations were identified in conserved amino acids (Fig. 2), including homozygous substitutions of proline for leucine ...
... These included homozygous nonsense mutations in codons 106 and 1142, a homozygous frameshift mutation, and heterozygous insertion mutations and splice-site mutations. Seven missense mutations were identified in conserved amino acids (Fig. 2), including homozygous substitutions of proline for leucine ...
UNC-4/UNC-37-dependent repression of motor neuron
... not been reported. (B) Homeodomain sequences of UNC-4-related proteins. Dots indicate identity to C. elegans UNC-4 sequence. Bold residues show similarity to UNC-4. (C) eh1 domains of nematode UNC-4 proteins (C. elegans and C. briggsae) are most similar to eh1 domains of Engrailed family members. Ve ...
... not been reported. (B) Homeodomain sequences of UNC-4-related proteins. Dots indicate identity to C. elegans UNC-4 sequence. Bold residues show similarity to UNC-4. (C) eh1 domains of nematode UNC-4 proteins (C. elegans and C. briggsae) are most similar to eh1 domains of Engrailed family members. Ve ...
Keep Your Fingers Off My DNA: Protein–Protein
... family of proteins have also been examined and partially mapped to specific amino acid positions. Ikaros is the founding member of a family of proteins composed of five proteins—Ikaros, Aiolos, Helios, Eos, and Pegasus—all of which maintain a conserved, characteristic domain architecture, containing ...
... family of proteins have also been examined and partially mapped to specific amino acid positions. Ikaros is the founding member of a family of proteins composed of five proteins—Ikaros, Aiolos, Helios, Eos, and Pegasus—all of which maintain a conserved, characteristic domain architecture, containing ...
How Complexity Originates: The Evolution of Animal Eyes
... (Nordström et al. 2004). Following such block duplication, each set of duplicates must also diverge in function, which requires other mutations after the duplication event. For coduplication to occur without whole genome duplication (and without many simultaneous, yet independent, mutations), cofun ...
... (Nordström et al. 2004). Following such block duplication, each set of duplicates must also diverge in function, which requires other mutations after the duplication event. For coduplication to occur without whole genome duplication (and without many simultaneous, yet independent, mutations), cofun ...
This Article Abstract Full Text (PDF) Alert me when this article is cited
... (1, 2). Wza is an outer membrane lipoprotein that multimerizes to form ring-like structures resembling secretins for type II and type III protein secretion (13). HMW CPS is believed to cross the outer membrane through this complex. WzcCPS (involved in group 1 CPS assembly) is a tyrosine autokinase, ...
... (1, 2). Wza is an outer membrane lipoprotein that multimerizes to form ring-like structures resembling secretins for type II and type III protein secretion (13). HMW CPS is believed to cross the outer membrane through this complex. WzcCPS (involved in group 1 CPS assembly) is a tyrosine autokinase, ...
Multidrug resistance mediated by the ATP-binding
... YOR1/YRS1, Z73066; LtpgpA, X17154. Several additional MRP-related proteins were not included because their complete cDNA sequences have not yet been published. ...
... YOR1/YRS1, Z73066; LtpgpA, X17154. Several additional MRP-related proteins were not included because their complete cDNA sequences have not yet been published. ...
Sec2 Protein Contains a Coiled-Coil Domain Essential for Vesicular
... for all vesicular transport events. Such a general role has been suggested for the product of the SEC18 gene (Wilson et al., 1989). In addition to components that act generally, there must also be components that are required for only a single event or subset of events. Components involved in regula ...
... for all vesicular transport events. Such a general role has been suggested for the product of the SEC18 gene (Wilson et al., 1989). In addition to components that act generally, there must also be components that are required for only a single event or subset of events. Components involved in regula ...
Midterm Exam Guidelines Sheet- Biology II 2015 Introduction List
... Construct the basic structure of an amino acid Describe how amino acids connect together to form polypeptides Identify and describe the 2 secondary shapes of polypeptide chains Describe the major types of proteins found in the body Explain the differences between DNA and RNA Describe and identify th ...
... Construct the basic structure of an amino acid Describe how amino acids connect together to form polypeptides Identify and describe the 2 secondary shapes of polypeptide chains Describe the major types of proteins found in the body Explain the differences between DNA and RNA Describe and identify th ...
Meiotic Induction of the Yeast HOP1 Gene Is
... complement a hopl diploid suggested that all the promoter and regulatory sites required for the proper expression of HOPJ lie within this small upstream region (12). In this report, we describe the isolation of two sites within the 207-bp promoter region that are required for proper transcriptional ...
... complement a hopl diploid suggested that all the promoter and regulatory sites required for the proper expression of HOPJ lie within this small upstream region (12). In this report, we describe the isolation of two sites within the 207-bp promoter region that are required for proper transcriptional ...
Protein Cross-linkers handbook and selection guide
... pH8.0. Below pH10.0, the reaction is likely to result in undesirable side reactions. However, the amidine formed is reversible at high pH. Imidoesters are used for protein subunit studies, molecular interactions, and for immobilization of proteins to solid supports. Imidoesters have been used as a s ...
... pH8.0. Below pH10.0, the reaction is likely to result in undesirable side reactions. However, the amidine formed is reversible at high pH. Imidoesters are used for protein subunit studies, molecular interactions, and for immobilization of proteins to solid supports. Imidoesters have been used as a s ...
The Genome-linked Protein of Picornaviruses. VIII. Complete Amino
... poliovirus VPg. It is 22 amino acids in length, 2354 Mr, and terminates in -valyl-glutamineCOOH. The nature of the carboxy-terminus did not surprise us since in the poliovirus polyprotein, from which VPg is ultimately derived, the terminal glutamine of VPg is followed by a glycine. Recently, glutami ...
... poliovirus VPg. It is 22 amino acids in length, 2354 Mr, and terminates in -valyl-glutamineCOOH. The nature of the carboxy-terminus did not surprise us since in the poliovirus polyprotein, from which VPg is ultimately derived, the terminal glutamine of VPg is followed by a glycine. Recently, glutami ...
PIPing on lysosome tubes
... Rong et al (2012) shows a masterful control of techniques needed to identify the machinery needed for ALR and efflux from the lysosome. Importantly, both papers looked at the lipid species present using lipid probes, and showed that kinase dead mutants of the kinases do not rescue. However, neither ...
... Rong et al (2012) shows a masterful control of techniques needed to identify the machinery needed for ALR and efflux from the lysosome. Importantly, both papers looked at the lipid species present using lipid probes, and showed that kinase dead mutants of the kinases do not rescue. However, neither ...
University of Groningen Expression and engineering of
... protease deficient strains levels of SC3 did not increase. Similar results were obtained when ABH3 was expressed in wild-type or protease deficient strains. This indicates that problems with the production of hydrophobins in A. niger arise intracellularly and at the posttranscriptional level. In Cha ...
... protease deficient strains levels of SC3 did not increase. Similar results were obtained when ABH3 was expressed in wild-type or protease deficient strains. This indicates that problems with the production of hydrophobins in A. niger arise intracellularly and at the posttranscriptional level. In Cha ...
Chapt. 14 Eukaryotic mRNA processing I: splicing 14.1 Genes are in
... Base pairing between U1 snRNA and 5’-splice site of precursor is necessary, not sufficient for splicing (Figs. 11-13, evidence from WT, mutant U1, E1A gene of Adenovirus: Compensatory mutations do not always restore splicing) ...
... Base pairing between U1 snRNA and 5’-splice site of precursor is necessary, not sufficient for splicing (Figs. 11-13, evidence from WT, mutant U1, E1A gene of Adenovirus: Compensatory mutations do not always restore splicing) ...
biochemistry module elective course contents
... Application of chromatographic methods of proteins and nucleic acids Application of chromatographic methods of proteins and nucleic acids Application of electrophoretic methods of proteins Application of electrophoretic methods of nucleic acids Biosensors used in routine analysis and relevant exampl ...
... Application of chromatographic methods of proteins and nucleic acids Application of chromatographic methods of proteins and nucleic acids Application of electrophoretic methods of proteins Application of electrophoretic methods of nucleic acids Biosensors used in routine analysis and relevant exampl ...
Conservation and Coevolution in the Scale
... Fraser, Wall, and Hirsh 2003). A recent study that dealt with several such relationships simultaneously demonstrated correlations between different measures of evolutionary conservation and various functional genomic parameters (Krylov et al. 2003). However, the findings of some of these evolutionar ...
... Fraser, Wall, and Hirsh 2003). A recent study that dealt with several such relationships simultaneously demonstrated correlations between different measures of evolutionary conservation and various functional genomic parameters (Krylov et al. 2003). However, the findings of some of these evolutionar ...
With-the-great-explosion-of-use-of
... This proposal was based on the association of species-specific proline substitutions in rodent IAPP 20-29, which prevents fibril formation. This single �-strand fragment was shown to form intermolecular hydrogen bonds and �sheets67. However, recent studies have identified a second potential amyloido ...
... This proposal was based on the association of species-specific proline substitutions in rodent IAPP 20-29, which prevents fibril formation. This single �-strand fragment was shown to form intermolecular hydrogen bonds and �sheets67. However, recent studies have identified a second potential amyloido ...
Serial Endosymbiotic Theory
... (bacteria) living within larger prokaryotic cells. Unlike plant and animal cells, prokaryotic cells contain no membrane bound organelles or an organized nucleus. Based on this theory, organelles such as the mitochondria in modern eukaryotic cells would be the evolutionary descendents of the aerobic ...
... (bacteria) living within larger prokaryotic cells. Unlike plant and animal cells, prokaryotic cells contain no membrane bound organelles or an organized nucleus. Based on this theory, organelles such as the mitochondria in modern eukaryotic cells would be the evolutionary descendents of the aerobic ...
Serial Endosymbiotic Theory
... (bacteria) living within larger prokaryotic cells. Unlike plant and animal cells, prokaryotic cells contain no membrane bound organelles or an organized nucleus. Based on this theory, organelles such as the mitochondria in modern eukaryotic cells would be the evolutionary descendents of the aerobic ...
... (bacteria) living within larger prokaryotic cells. Unlike plant and animal cells, prokaryotic cells contain no membrane bound organelles or an organized nucleus. Based on this theory, organelles such as the mitochondria in modern eukaryotic cells would be the evolutionary descendents of the aerobic ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.